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While GBMSM living with HIV in Australia have higher rates of drug use compared to other GBMSM, and the general population, our analysis indicates that patterns of drug use are not uniform within this group. Specific patterns of drug use are related to distinct health inequalities, and this should be accounted for when addressing the needs of men who use drugs differently.

While GBMSM living with HIV in Australia have higher rates of drug use compared to other GBMSM, and the general population, our analysis indicates that patterns of drug use are not uniform within this group. Specific patterns of drug use are related to distinct health inequalities, and this should be accounted for when addressing the needs of men who use drugs differently.Over the recent few years, several DNA collection techniques and methodologies have been published for the recovery of DNA from fired cartridge cases. In this study, swabbing, the DNA collection technique currently used in our jurisdiction (NSW, Australia), was compared with tape lifting and soaking to assess DNA recovery rates, DNA quality and profile quality. Brass .22LR and 9mmP cartridges were used as they are the most commonly encountered in our jurisdiction. The cartridges (n = 107) were loaded into cleaned firearm magazines by three volunteers of unknown shedder status, to mimic routine casework sample types. Half of the handled cartridges were fired whilst the other half were kept unfired. STR genotypes were produced at both 29 and 30 PCR cycles to evaluate which improved handler allele detection. Epigenetic pathway inhibitors DNA recovery rates showed that swabbing recovered significantly less DNA than tape lifting and soaking. Whilst there were no significant differences between tape lifting and soaking, tape lifting, on average level of background DNA. Furthermore, increasing the number of PCR cycles to 30 also increased the detection of non-handler alleles in DNA profiles. Our results suggest tape lifting yields more uploadable profiles from unfired and fired cartridge cases than swabbing but also more adventitious (non-handler) alleles. However additional research will be needed to evaluate the full potential of this method.

Long-term opioid therapy presents health risks for people with chronic pain. Some chronic pain patients escalate their opioid dose to regulate negative emotions. Therefore, emotion regulatory strategies like reappraisal are key treatment targets for this population. Mindfulness has been shown to enhance reappraisal, but the mechanisms of action are unknown. This study was a secondary analysis of data from a randomized, controlled trial of Mindfulness-Oriented Recovery Enhancement (MORE) to test a specific postulate of the Mindfulness-to-Meaning Theory that mindfulness-based interventions promote reappraisal, via interoceptive self-regulation, as a means of decreasing emotional distress.

Ninety-five patients with opioid-treated chronic pain (age = 56.8 ± 11.7, 66% female) were randomized to 8 weeks of MORE or Support Group (SG) psychotherapy. An interoceptive awareness latent variable was constructed from the Multidimensional Assessment of Interoceptive Awareness (MAIA). Next, interoceptive self-regulationfied by the Mindfulness-to-Meaning Theory.

Atypical serum protein electrophoresis (SPE) profiles may arise in patients who received allogeneic hematopoietic stem cell transplantation (allo-HSCT), but little is known about their clinical significance. Atypical SPE combine either monoclonal and oligoclonal components, suspected on SPE and confirmed by immunofixation. The aim of the study is to analyze the incidence, the etiology and the clinical significance of atypical SPE profiles in patients who received allo-HSCT.

This retrospective study enrolled 117 patients with myeloid malignancies who received an allo-HSCT between 2012 and 2018. We excluded patients with lymphoid malignancies or multiple myeloma, patients presenting atypical electrophoresis prior to transplantation and patients who died within 100 days post-transplant.

Atypical SPE occurred in 42.7% of patients. The cumulative incidence of atypical profiles was significantly higher in patients with acute Graft Versus Host Disease (GVHD, p=0.019) and in patients with Cytomegalovirus (CMV) reactivation (p=0.0017). We observed for the first time that atypical SPE profiles mostly occurred in patients transplanted from a CMV+ donor (p=0.031). CMV reactivation preceded the occurrence of atypical SPE in the majority of patients. We show that atypical SPE delay the relapse of the underlying malignant disease (486vs 189 days, p=0.006), and significantly improve overall survival (OS; 33.1 months vs 28.3 months, p=0.049). In both univariate and multivariate analyzes, the presence of an atypical SPE is the only factor that significantly improves OS.

The occurrence of atypical SPE profiles after allo-HSCT may reflect an adapted post-transplant immune response leading to favourable outcomes.

The occurrence of atypical SPE profiles after allo-HSCT may reflect an adapted post-transplant immune response leading to favourable outcomes.

There are burgeoning bodies of research on cyberbullying and online sexual harassment. Yet existing work often fails to distinguish between these two unique forms of online victimization, is largely cross sectional, and based on convenience or specialized samples. We examined the prevalence, predictors, and mental health and behavioral consequences of cyberbullying and online sexual harassment using a large, representative sample of adolescents. We also considered the potential compounding effects of multiple forms of victimization, as well as gender differences in the effects of online victimization.

We used nationally representative, longitudinal data from the National Survey on Teen Relationships and Intimate Violence (STRiV) (n = 1,152), a US-based sample of adolescents 10-18 years old.

Approximately 37% of participants reported being victims of cyberbullying, and nearly 15% reported online sexual harassment experiences. Despite cyberbullying being relatively more common, the risk factors for these periences underscore the importance of making distinctions. We provide recommendations for future research and programmatic efforts.

Adolescents typically spend decreasing amounts of time with family members, but the COVID-19 pandemic changed this pattern for many youth. The objective of the current study was to better understand adolescents' perceived change in family relationship quality, and how these perceptions were related to psychosocial functioning during the COVID-19 pandemic, accounting for more traditional measures of family relationship quality. Understanding how adolescents perceived change in relationship quality with family members during the pandemic offers novel insight into adolescents' relationships with their families and psychosocial functioning during this period.

A sample of Canadian adolescents (N=605, ages 14 to 18, 53% girls), was employed to examine patterns of adolescents' perceived change in relationship quality with parents and siblings since the start of the pandemic, accounting for relationship quality, pandemic-related characteristics, and demographic variables.

Four latent profiles were identified youth who perceived (1) low change, (2) improvement only, (3) moderate instability and (4) high instability in relationship quality. Higher perceived instability was associated with poorer functioning, with youth who reported only improvement reporting the highest overall level of functioning.

Adolescent perceptions of change in relationship quality were heterogeneous, and contribute to psychosocial functioning over and above their general evaluations of relationship quality. In particular, youth who perceive considerable change in their relationships with siblings and parents may require additional support in response to the COVID-19 pandemic.

Adolescent perceptions of change in relationship quality were heterogeneous, and contribute to psychosocial functioning over and above their general evaluations of relationship quality. In particular, youth who perceive considerable change in their relationships with siblings and parents may require additional support in response to the COVID-19 pandemic.There is an established relationship between acceptance of cosmetic surgery and psychological factors, including body image. However, qualitative research among diverse cultural groups is needed to provide a more fine-grained understanding of the influences on women's attitudes towards cosmetic surgery. In this study, 20 Chinese and 20 Dutch women aged 18-50 years (MChinese = 34.20; MDutch = 34.70) participated in one-on-one semi-structured interviews. Data were analyzed using reflexive thematic analysis. We identified three themes that captured the factors that women perceived to foster favorable attitudes towards cosmetic surgery (a) sociocultural pressures (e.g., normalization of cosmetic surgery, appearance-focused peers); (b) intrapersonal characteristics (e.g., beauty-ideal internalization, social comparison); and (c) benefits of beauty (e.g., attracting men, socioeconomic benefits). Conversely, two themes captured the factors perceived to reduce favorable attitudes towards cosmetic surgery (a) intrapersonal characteristics (e.g., unconditional body acceptance, self-confidence); and (b) external considerations (e.g., health risks, financial costs). Overall, Chinese and Dutch participants shared many similarities in their opinions about what might affect cosmetic surgery consideration. The most striking cross-cultural differences concerned perceived socioeconomic benefits of beauty (mainly Chinese women) and women's conceptualization of body appreciation. This study may enable a more comprehensive understanding about the factors influencing Chinese and Dutch women's attitudes towards cosmetic surgery, and the nuances in these relationships across these cultures.Aerobic biocathodes are effective construct for the simultaneous nitrification and denitrification, but the disturbance of cathodic oxygen reduction on ammonia oxidation and denitrification remains unclear. In this study, we revealed the oxygen reduction peak at -0.4 V (versus silver/silver chloride) by cyclic voltammetry analysis at a cathode without a biofilm. The reduction peak, however, showed a right shift from -0.4 to -0.3 V for the biocathode, indicating that the aerobic biocathode could simultaneously perform traditional nitrification and cathode oxygen reduction. Therefore, different electrode potentials ranging from -0.5 to -0.1 V were designed for regulating the ammonia oxidation rate, and the results showed that the highest oxidation rate reached 3.08 mg/h/L at a potential of -0.2 V under a low-aeration rate of 5 mL/min. High-throughput sequencing showed that Nitrosomonas and Rhodococcus were the dominant nitrogen removal genera in the biocathode, and the abundance of Devosia was related to the interactions between the aeration rate and the electrode potential. Furthermore, the amoC and hao genes responded to aeration and electrode potential regulation, and -0.2 V was more suitable for promoting the denitrification process under low-aeration conditions. Therefore, these findings provided new insights on cathodic potential control for ammonia oxidation and nitrogen removal as well as for the regulation of microbial communities.