Loftyates0964

Therefore regarding children of sudden generalized convulsion with even minute abdominal findings or recent gastrointestinal history, it is necessary to pay attention and evaluate the abdomen by a CT or MRI besides the nervous system at the first impression. 2020 Translational Pediatrics. All rights reserved.Hereditary gingival fibromatosis (HGF) is characterized by an accumulation of extracellular matrix resulting in a fibrotic enlargement of keratinized gingiva. The goal of this article is to describe one kindred affected with HGF and discuss the diagnosis, treatment, recurrence risk and histopathology features of the proband with mixed dentition. An 8-year-old boy reported with a chief complaint of gingival enlargement. A series of examinations were performed to make a diagnosis and family histories of the patient were recorded. Surgical therapy included gingivectomy and gingivoplasty technique were performed for the proband to remove excess gingiva. Collagen bundles in the permanent incisors area were prevalently significantly bulkier than that of the deciduous teeth area and the arrangement was much more regular. Microscopic evaluation revealed that epithelial hyperplasia was severe in tissue with intense inflammation, whereas tissue with mild inflammation showed only long and deep epithelial papillae. The patient was placed on a 3-month recall schedule and didn't demonstrate any recurrence of gingival overgrowth over a 1-year follow-up period. The study revealed that the eruption of permanent teeth played an important role in accelerating gingival hyperplasia. For the first time, it was confirmed from histological perspective that inflammation in gingival tissue was crucial to the gingival overgrowth of HGF. 2020 Translational Pediatrics. All rights reserved.We provide a case report of two thyroid nodules in an 8-year-old girl, which revealed malignant ultrasonographic findings and which were confirmed as ectopic thymic tissue by total thyroidectomy. The ultrasound presentations of intrathyroidal thymus glands were similar to those of the malignant thyroid nodules. In addition, in this case, there were two ectopic thymus lesions in the thyroid gland, which undoubtedly increased the difficulty of diagnosis. The occurrence of multiple ectopic thymic lesions in the thyroid gland was different from previous reports. Therefore, clinicians should take into consideration this rare entity, and should not mistake it as a thyroid neoplasm; moreover, they should not perform extensive thyroid resection. 2020 Translational Pediatrics. Tacrine cost All rights reserved.We report a case of a 7-month-old girl who presented with 2 months history of redness and swelling syndromes around the left ankle. The local hospital diagnosis of left ankle soft tissue infection and gave antibiotic treatment. However, her symptoms were failed respond to the antibiotic treatment and suggested to transfer to our hospital. We gave this girl a detailed physical examination, when opening the ankle crease a hidden rubber band was found and the surrounding soft tissues were lacerated. As a result, the child was taken to surgery to remove the band and repair the lacerated structures and her postoperative recovery was well. A rubber band worn for decorative purpose or accidently by the child is sometimes missed by the parents and remains long unnoticed. For the clinical features of a linear constricting scar around the wrist or ankle in the presence of a swollen syndrome, it should always alert the clinician to the possibility of a forgotten band around the joints. This appears to be the first case of acquired rubber band syndrome reported occurred on children's ankle. 2020 Translational Pediatrics. All rights reserved.To report a case of intracranial hemorrhage in an 86-day-old boy with late-onset group B streptococcus (GBS) disease and review the literature of GBS disease. Physical and auxiliary examinations and PubMed search with keywords of "GBS disease" and "intracranial hemorrhage". The 86-day-old boy was admitted to hospital for respiratory arrest. High tension in bregma indicated intracranial infection. Laboratory examination showed low red blood cell account, low white blood cell account and high C-reactive protein account. Also, GBS was positive in cerebrospinal fluid (CSF) and blood culture. Computed tomography (CT) indicated intracranial hemorrhage. Meropenem and other supportive treatment started immediately. Because of the patient's poor condition, the patient's parents abandoned the treatment. As for literature review, intracranial hemorrhage is rarely seen in late-onset disease (LOD). The case contributes to further exploration on the syndromes of GBS disease. Clinical workers should notice the complexity of bacterial infection. The relationship between polluted breast milk and infection remains to be explored. 2020 Translational Pediatrics. All rights reserved.Background The newly identified 2019-nCoV, which appears to have originated in Wuhan, the capital city of Hubei province in central China, is spreading rapidly nationwide. A number of cases of neonates born to mothers with 2019-nCoV pneumonia have been recorded. However, the clinical features of these cases have not been reported, and there is no sufficient evidence for the proper prevention and control of 2019-nCoV infections in neonates. Methods The clinical features and outcomes of 10 neonates (including 2 twins) born to 9 mothers with confirmed 2019-nCoV infection in 5 hospitals from January 20 to February 5, 2020 were retrospectively analyzed. Results Among these 9 pregnant women with confirmed 2019-nCoV infection, onset of clinical symptoms occurred before delivery in 4 cases, on the day of delivery in 2 cases, and after delivery in 3 cases. In most cases, fever and a cough were the first symptoms experienced, and 1 patient also had diarrhea. Of the newborns born to these mothers, 8 were male and 2 weretopenia accompanied by abnormal liver function, and even death. However, vertical transmission of 2019-nCoV is yet to be confirmed. 2020 Translational Pediatrics. All rights reserved.Background Cancer remains the number one cause of disease-related mortality in children, and despite advances in the molecular understanding of leukemia and targeted therapies, refractory leukemia remains a leading cause of death. It therefore is essential to further define features, e.g., FLT3 alterations and KMT2A rearrangements, associated with inferior survival early to augment or alter therapeutic strategies to improve outcomes. Methods To gain insights into the genetic drivers predictive of aggressive clinical behavior among pediatric leukemia patients, we performed comprehensive integrative clinical sequencing (ICS), including paired tumor/normal DNA sequencing and RNA-seq, for pediatric patients who presented at our institution over a period of five years with acute lymphoblastic or myelogenous leukemia (ALL and AML; n=43) and high-risk clinical features (high white blood cell count, extramedullary disease, or refractory and/or relapsed disease). Results We found that RAS- and Ras-pathway aberrations, including N-RAS, NF1 and PTPN11, are frequent somatic mutations and, importantly, associated with decreased event free and overall survival (OS) (P=0.