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This study aimed to investigate the optimal jailed balloon inflation in the side branch during the modified jailed balloon technique for bifurcated lesions.

The modified jailed balloon technique is one of the effective techniques to minimize the emergence of side branch (SB) compromise by preventing plaque or carina shifting during a single stent strategy in the main vessel with provisional SB treatment. However, there are no detailed studies on the method of optimal jailed balloon inflation.

We analyzed 51 consecutive patients who underwent percutaneous coronary intervention (PCI) for bifurcated lesions with a modified jailed balloon technique between September 2018 and December 2020. These 51 patients were divided into two groups according to the magnitude of inflation pressure of the jailed balloon a higher pressure (HP) group and lower pressure (LP) group.

No significant differences in procedural outcomes were observed between the two groups. The findings of SB compromise were relatively common with our procedure (30.0% in the HP group; 33.3% in the LP group). The patterns of SB compromise such as dissection or stenosis increase were observed at similar frequencies between them. In particular, SB dissection was noted in the SB lesion with some plaque burden, irrespective of the magnitude of the jailed balloon inflation pressure. Univariate analysis showed that calcification in the main vessel and SB lesion length was significantly associated with SB compromise. Finally, all PCI procedures were successfully completed without any provisional stent deployment in SB.

We speculate that lesion characteristics rather than the PCI procedural factors may be critical determinants to cause SB compromise.

We speculate that lesion characteristics rather than the PCI procedural factors may be critical determinants to cause SB compromise.Land use change is one of the challenges that aggravate environmental problems. Understanding the scope of land use change, driving forces, and consequences is very crucial for proper management of land resources. We investigated land use/land cover changes using remote sensing data (for the years 1973, 1995, and 2017), and field observation, household survey, key informant interview, and focus group discussion were used to determine the drivers and consequences of land use/land cover changes in Shenkolla watershed, south central Ethiopia. Unsupervised and supervised classification techniques were employed to get thematic information from satellite imagery. ArcGIS 10.3 and QGIS v 3.0 softwares were used to accomplish the analysis. The results disclosed that Shenkolla watershed has changed significantly during the past 4 decades between 1973 and 2017. This observed change indicates a reduction in forest land and an increase in agricultural land. Forest land was reduced from 29.51% in 1973 to 20.52% in 2017, but agricultural land was expanded from 70.49% in 1973 to 79.48% in 2017. Agricultural expansion, policy change and social unrest, population pressure, shortage of farm land, and biophysical factors were major driving forces of the LU/LC changes. Environmental implications such as climate change, biodiversity loss, scarcity of basic forest products, habitat alteration, decline in quality and availability of water, and crop yield reduction are the consequences of the LU/LC change. The expansion of agricultural land at the expense of forest cover in Shenkolla watershed has negative implications on the natural resources and the livelihood of local people. Hence, appropriate measures need to be employed to reduce the dramatic change in land use and to harmonize environmental conservation with human livelihood.Biopiracy as "a silent disease" is hardly detectable because it does not leave traces frequently. The corporate hijacking of food is the most important health hazard in this era; giant commercial enterprises are using intellectual property rights to patent indigenous medicinal plants, seeds, genetic resources, and traditional medicines. The new era of biotechnology relies on the genes of living organisms as raw materials. The "Gene Rush" has thus become similar to that of the old "Gold Rush." Sri Lanka has been spotted in the top 34 biodiversity hotspots globally. Moreover, localized in the tropics, human generations in Sri Lanka have utilized the array of plant species for herbal treatments and treatment of diseases. Sri Lanka after its 30-year civil war is moving towards a solid growth and conservation of the environment which is a major component in a sustainable development where the conservation of biodiversity plays a significant role. In this paper, we present an overview of typical cases of global biopiracy, bioprospecting via introduction of cost-effective deoxyribonucleic acid (DNA) fingerprinting and international protocol with Private-Public-People Partnership concept as excellent forms of utilization of natural resources. We propose certain perspectives as scientists towards abolishing biopiracy and also to foster the fair utilization of natural resources; since the economy of most developing countries is agriculture based, the gross domestic product of the developing countries could be increased by enhanced bioprospecting via introduction of cost-effective DNA fingerprinting technologies and thus not being a pray of corporate hijacking."Biopiracy is biological theft; illegal collection of indigenous plants by corporations who patent them for their own use" (Vandana Shiva).Preparation of cross-linked chitosan beads using dual crosslinkers of tripolyphosphate (TPP) and epichlorohydrin (ECH) for the adsorption and kinetic studies of methyl orange (MO) had been carried out. FTIR spectra showed that TPP could act as the protecting agent of the NH2 group of chitosan and ECH reacted with the primary hydroxyl group of chitosan. learn more Various concentrations of TPP, ECH, and immersing time in the TPP solution for bead formation were studied. The effect of pH and kinetics of adsorption were investigated to define the mechanism of adsorption and rate-limiting step. As a result, pH 3, 10% (w/v) TPP, 5% (v/v) ECH, and 12 h immersing time in TPP were selected as the optimum conditions for preparing the beads as indicated by the highest adsorption amount of MO. The cross-linked chitosan beads' adsorption capacity for MO under optimum condition was found to be 79.55 mg/g with the adsorption rate constant (k) of 1.29 × 10-3/min. Furthermore, it was found that a low concentration of ECH could maintain the stability of chitosan in acidic conditions, whereas the concentration of TPP and immersing time controlled pore size and morphology of chitosan beads.

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