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Lactobacillus supplementation has a beneficial effect on low-density lipoprotein cholesterol and total cholesterol in adults who are overweight or obese, and also on fasting plasma glucose and triglycerides under certain conditions. Therefore, Lactobacillus supplementation represents a promising approach in the management of obesity-related diseases.

Scientific publications from India and Asiatic countries are on rising in the last decade. We have attempted to analyze the growth (over the last 3 years) of various important journals being published from India in various medical fields, especially in the specialty of Endocrinology, Diabetes, and Metabolism.

We used the database of SCOPUS, SCIMAGO, and Academic Accelerator to derive the required statistical information from various Indian journals, till 9

June 2022.

There are only a very few medical journals from India in Quartile 1(first 25% of all journals), namely Diabetes and Metabolic Syndrome Clinical Research and Reviews (DMSCRR), Hepatology International, and the Indian Journal of Medical Research (IJMR). DMSCRR stands at #1 in Diabetes and Metabolic disease-related journals among all the medical journals from India. All metrics of DMSCRR have majorly increased over the last three years; its CiteScore has almost quadrupled, the h-index is doubled, and the number of citations received has quadrupled. The DMSCRR is now ranked globally at #23/227 (90

percentile) amongst all Endocrinology, Diabetes, and Metabolic journals. In the recently announced metrics by SCOPUS in June 2022, the DMSCRR has ranked as the #1 journal in Asiatic countries.

Some Indian journals have increased their rankings in 2021 and among them, the Diabetes Metabolic Syndrome Clinical Research & Reviews has now become the highest-ranked medical journal in India, not only in the field of Endocrinology, Diabetes, and Metabolism but also in all the medical specialties.

Some Indian journals have increased their rankings in 2021 and among them, the Diabetes Metabolic Syndrome Clinical Research & Reviews has now become the highest-ranked medical journal in India, not only in the field of Endocrinology, Diabetes, and Metabolism but also in all the medical specialties.Visualizing macromolecules inside bacteria at a high spatial resolution has remained a challenge owing to their small size and limited resolution of optical microscopy techniques. Recent advances in cryo-electron tomography (cryo-ET) imaging methods have revealed the spatial and temporal assemblies of many macromolecules involved in different cellular processes in bacteria at a resolution of a few nanometers in their native milieu. Specifically, the application of cryo-focused ion beam (cryo-FIB) milling to thin bacterial specimens makes them amenable for high-resolution cryo-ET data collection. In this review, we highlight recent research in three emerging areas of bacterial cell biology that have benefited from the cryo-FIB-ET technology - cytoskeletal filament assembly, intracellular organelles, and multicellularity.Anticipation of teammates and opponents is a critical factor in many sports played in interactive environments. Deceptive actions are used in sports such as basketball to counteract anticipation of an opponent. In this study, we investigated the effects of shot deception on the players' anticipation behaviour in basketball. Thirty one basketball players (15 expert, 16 novice) watched life-sized videos of basketball players performing real shots or shot fakes aimed at the basket. Four different shot outcomes were presented in the video stimuli a head fake, a ball fake, a high shot fake, and a genuine shot. The videos were temporally occluded at three different time points (-160 ms, -80 ms, 0 ms to ball release) during a shooting motion. The participants had to perform a basketball-related response action to either shots or shot fakes. Response accuracy, response time, and decision confidence were recorded along with gaze behaviour. Anticipation accuracy was reduced at later occlusion points for fake shooting actions. For expert athletes, this effect occurred at later occlusion points compared to novices. The gaze analysis of successful and unsuccessful shot anticipations revealed more gaze fixations towards the hip and legs in successful anticipations, whereas more fixations towards the ball and the head were found in shots unsuccessfully anticipated. It is proposed that hip and leg regions may contain causal information concerning the vertical trajectory of the shooter and identifying this information may be important for perceiving genuine and deceptive shots in basketball.Many advanced microfluidic Lab-on-disc (LOD) devices require an on-board power supply for powering active components. LODs with an on-board electrical power supply are called electrified-LODs (eLODs) and are the subject of the present review. This survey comprises two main parts. First, we discuss the different means of delivering electrical energy to a spinning disc including slip-ring, wireless power transmission, and on-board power supply. In the second part, we focus on utilizing electrical power on eLODs for three electrokinetic microfluidic processes electrophoresis, electroosmotic flow, and dielectrophoresis. Electrokinetic phenomena enable propulsion, separation, and manipulation of different fluids and various types of microparticles/cells. We summarize the theoretical and experimental results for all three electrokinetic phenomena enacted on centrifugal platforms. While extensive numerical modeling and experimental research are available for electrokinetics on stationary platforms, there is a noticeable lack of development in this area when executed on rotating platforms. The review concludes by comparing the strengths and weaknesses of different electrokinetic techniques implemented on centrifugal platforms, and additionally, the most promising applications of electrokinetic-assisted eLOD devices are singled out.Flap endonuclease 1 (FEN1) is a structure-specific nuclease, which catalyzes the removal of 5' overhanging DNA flap from a specific DNA structure. FEN1 has been considered as an important biomarker for cancer diagnosis since it is over-expressed in various types of human tumor cells and closely related to cancer development. Nanoprobes gradually become basic tools for analyzing biomarkers variations in vivo. Here, we utilized aminoated mesoporous silica nanoparticles (NH2-MSNs) with a rich porous structure as the fluorescence nanoprobes to entrap the rhodamine 6G (Rh6G) molecules. Then gold nanoparticles linked specific single-stranded DNA (AuNPs-ssDNA) as a molecular gate was used to coat the NH2-MSNs surface. The fluorescence signal was weak when the fluorescence molecules were blocked by the AuNPs-ssDNA. In the presence of FEN1, it recognized and cleaved the specific ssDNA to release the Rh6G from NH2-MSNs, which resulted in recovered fluorescence signals. Thus, the sensitive detection of FEN1 activity was realized by controlled-release of Rh6G. The fluorescence signal showed a good linear relationship with the logarithm of FEN1 activity ranging from 0.05 to 1.75 U with a detection limit of 0.03 U. Moreover, confocal imaging demonstrated that the proposed biosensor could distinguish tumor cells from normal cells. Therefore, this technique contributes to clinical diagnostic and therapeutic monitoring.Despite the great promise of cancer theranostic platforms, accurate diagnosis and effective treatment are still highly challenging. In this work, nanodevice for intracellular miRNAs detection and artificially controlled drug releasement was developed based on upconverting nanoparticles (UCNPs). For analysis aspect, DNAzymes amplified miRNA-21 detection was carried out, giving excellent sensitivity with detection limits of 1.8 × 10-11 M. Moreover, intracellular fluorescence imaging permitted in situ diagnoses of miRNA-21 expression in living cells. Once the test identifies tumor markers, treatment can be performed. Here, artificially controlled chemo-gene synergetic therapy nanodevice was obtained by integrating UCNPs with photocleavable linkers (PC-linkers). In vitro and in vivo experiments verified the potential application of prepared nanodevice in cancer theranostics.Balance disorders affect approximately 30% of the population throughout their lives and result in debilitating symptoms, such as spontaneous vertigo, nystagmus, and oscillopsia. The main cause of balance disorders is peripheral vestibular dysfunction, which may occur as a result of hair cell loss, neural dysfunction, or mechanical (and morphological) abnormality. The most common cause of vestibular dysfunction is arguably vestibular hair cell damage, which can result from an array of factors, such as ototoxicity, trauma, genetics, and ageing. One promising therapy is the vestibular prosthesis, which leverages the success of the cochlear implant, and endeavours to electrically integrate the primary vestibular afferents with the vestibular scene. Other translational approaches of interest include stem cell regeneration and gene therapies, which aim to restore or modify inner ear receptor function. However, both of these techniques are in their infancy and are currently undergoing further characterization and development in the laboratory, using animal models. Another promising translational avenue to treating vestibular hair cell dysfunction is the potential development of artificial biocompatible hair cell sensors, aiming to replicate functional hair cells and generate synthetic 'receptor potentials' for sensory coding of vestibular stimuli to the brain. Recently, artificial hair cell sensors have demonstrated significant promise, with improvements in their output, such as sensitivity and frequency selectivity. This article reviews the history and current state of bioelectronic devices to interface with the labyrinth, spanning the vestibular implant and artificial hair cell sensors.Immunosensor is a promising tool for natural parathion-methyl (PTM) detection, and its analytical advantages can be magnified by introducing flexibly-fabricating technique. Herein, we present a dual-electric-field PTM immunosensor on highly-compatible screen-printed electrode (SPE). Selleck CDK inhibitor MXene-Au, the product of in-situ gold nanoparticle growth on MXene, provides considerable binding sites for PTM antigen (ATG) and methylene blue (MB). During sensing, the MXene-Au-MB-ATG probe competitively binds antibody against PTM, composing a ratiometric immune-system. With DC-biased sine excitations from complementary waveforms, on-chip electric field couple improves immunoreactions among PTM, probe, and antibody. Electric field distribution is programmed by trimming bypass resistors to pursue optimal performance. Probe synthesis is solidly proven with morphological examinations, and competition mechanism between the probe and target PTM is clarified in electrochemical analyses. Remarkably, this method brings less consumption of immune time than electric-field-free or solo-electric-field setup (50 s vs. 900 or 70 s), and simultaneously provides more powerful ratiometric signal than the rivals. Log-linear relationship, between PTM level and sensor readout, is established in 0.02-38 ng/mL, and limit of detection is found as 0.01 ng/mL. This method is applied in laboratorial and natural PTM analyses, and the readouts are consistent with high performance liquid chromatography and recovery test.