Liuwiley7363

In essence, we put forth a framework to explore the cognitive space in a comprehensive manner, for each individual separately, and at different levels of granularity. This tool that can also quantify the FN reconfigurations that result from the brain switching between mental states.Modeling communication dynamics in the brain is a key challenge in network neuroscience. Vorinostat manufacturer We present here a framework that combines two measurements for any system where different communication processes are taking place on top of a fixed structural topology path processing score (PPS) estimates how much the brain signal has changed or has been transformed between any two brain regions (source and target); path broadcasting strength (PBS) estimates the propagation of the signal through edges adjacent to the path being assessed. We use PPS and PBS to explore communication dynamics in large-scale brain networks. We show that brain communication dynamics can be divided into three main "communication regimes" of information transfer absent communication (no communication happening); relay communication (information is being transferred almost intact); and transducted communication (the information is being transformed). We use PBS to categorize brain regions based on the way they broadcast information. Subcortical regions are mainly direct broadcasters to multiple receivers; Temporal and frontal nodes mainly operate as broadcast relay brain stations; visual and somatomotor cortices act as multichannel transducted broadcasters. This work paves the way toward the field of brain network information theory by providing a principled methodology to explore communication dynamics in large-scale brain networks.We propose that the application of network theory to established psychological personality conceptions has great potential to advance a biologically plausible model of human personality. Stable behavioral tendencies are conceived as personality "traits." Such traits demonstrate considerable variability between individuals, and extreme expressions represent risk factors for psychological disorders. Although the psychometric assessment of personality has more than hundred years tradition, it is not yet clear whether traits indeed represent "biophysical entities" with specific and dissociable neural substrates. For instance, it is an open question whether there exists a correspondence between the multilayer structure of psychometrically derived personality factors and the organizational properties of traitlike brain systems. After a short introduction into fundamental personality conceptions, this article will point out how network neuroscience can enhance our understanding about human personality. We will examine the importance of intrinsic (task-independent) brain connectivity networks and show means to link brain features to stable behavioral tendencies. link2 Questions and challenges arising from each discipline itself and their combination are discussed and potential solutions are developed. We close by outlining future trends and by discussing how further developments of network neuroscience can be applied to personality research.

Determine if chronic low back pain (LBP) is associated with DNA methylation signatures in human T cells that will reveal novel mechanisms and potential therapeutic targets and explore the feasibility of epigenetic diagnostic markers for pain-related pathophysiology.

Genome-wide DNA methylation analysis of 850,000 CpG sites in women and men with chronic LBP and pain-free controls was performed. T cells were isolated

discovery cohort, n = 32) and used to identify differentially methylated CpG sites, and gene ontologies and molecular pathways were identified. A polygenic DNA methylation score for LBP was generated in both women and men. Validation was performed in an independent cohort

validation cohort, n = 63) of chronic LBP and healthy controls.

Analysis with the discovery cohort revealed a total of 2,496 and 419 differentially methylated CpGs in women and men, respectively. In women, most of these sites were hypomethylated and enriched in genes with functions in the extracellular matrix, in the immune system (ie, cytokines), or in epigenetic processes. In men, a unique chronic LBP DNA methylation signature was identified characterized by significant enrichment for genes from the major histocompatibility complex. Sex-specific polygenic DNA methylation scores were generated to estimate the pain status of each individual and confirmed in the validation cohort using pyrosequencing.

This study reveals sex-specific DNA methylation signatures in human T cells that discriminates chronic LBP participants from healthy controls.

This study reveals sex-specific DNA methylation signatures in human T cells that discriminates chronic LBP participants from healthy controls.Successful performance in cooperative activities relies on efficient task distribution between co-actors. Previous research found that people often forgo individual efficiency in favor of co-efficiency (i.e., joint-cost minimization) when planning a joint action. The present study investigated the cost computations underlying co-efficient decisions. We report a series of experiments that tested the hypothesis that people compute the joint costs of a cooperative action sequence by summing the individual action costs of their co-actor and themselves. We independently manipulated the parameters quantifying individual and joint action costs and tested their effects on decision making by fitting and comparing Bayesian logistic regression models. Our hypothesis was confirmed people weighed their own and their partner's costs similarly to estimate the joint action costs as the sum of the two individual parameters. Participants minimized the aggregate cost to ensure co-efficiency. The results provide empirical support for behavioral economics and computational approaches that formalize cooperation as joint utility maximization based on a weighted sum of individual action costs.Are religious beliefs psychologically different from matter-of-fact beliefs? Many scholars say no that religious people, in a matter-of-fact way, simply think their deities exist. link3 Others say yes that religious beliefs are more compartmentalized, less certain, and less responsive to evidence. Little research to date has explored whether lay people themselves recognize such a difference. We addressed this question in a series of sentence completion tasks, conducted in five settings that differed both in religious traditions and in language the United States, Ghana, Thailand, China, and Vanuatu. Participants everywhere routinely used different verbs to describe religious versus matter-of-fact beliefs, and they did so even when the ascribed belief contents were held constant and only the surrounding context varied. These findings support the view that people from diverse cultures and language communities recognize a difference in attitude type between religious belief and everyday matter-of-fact belief.Humans rely extensively on external representations such as drawings, maps, and animations. While animations are widely used in infancy research, little is known about how infants interpret them. In this study, we asked whether 19-month-olds take what they see on a screen to be happening here and now, or whether they think that on-screen events are decoupled from the immediate environment. In Experiments 1-3, we found that infants did not expect a falling animated ball to end up in boxes below the screen, even though they could track the ball (i) when the ball was real or (ii) when the boxes were also part of the animation. In Experiment 4, we tested whether infants think of screens as spatially bounded physical containers that do not allow objects to pass through. When two location cues were pitted against each other, infants individuated the protagonist of an animation by its virtual location (the animation to which it belonged), not by its physical location (the screen on which the animation was presented). Thus, 19-month-olds reject animation-reality crossovers but accept the depiction of the same animated environment on multiple screens. These results are consistent with the possibility that 19-month-olds interpret animations as external representations.Beliefs about the world affect language processing and interpretation in several empirical domains. In two experiments, we tested whether subjective prior beliefs about the probability of utterance content modulate projection, that is, listeners' inferences about speaker commitment to that content. We find that prior beliefs predict projection at both the group and the participant level the higher the prior belief in a content, the more speakers are taken to be committed to it. This result motivates the integration of formal analyses of projection with cognitive theories of language understanding.[This corrects the article DOI 10.1021/acsomega.0c04784.].The structural evolution of polyglycolide (PGA) and poly(glycolide-co-lactide) (P(GA-co-LA)) with 8% LA content fibers with different heat-setting temperatures was investigated during in vitro degradation using WAXD, SAXS, and mechanical property tests. It was found that the PGA fiber was more susceptible to the degradation process than the P(GA-co-LA) fiber and a higher heat-setting temperature reduced the degradation rate of the two samples. The weight and mechanical properties of the samples showed a gradual decrease during degradation. We proposed that the degradation of PGA and P(GA-co-LA) fibers proceeded in four stages. A continuous increase in crystallinity during the early stage of degradation and a gradual decline during the later period indicated that preferential hydrolytic degradation occurred in the amorphous regions, followed by a further degradation in the crystalline regions. The cleavage-induced crystallization occurred during the later stage of degradation, contributing to an appreciable decrease in the long period and lamellar thickness of both PGA and P(GA-co-LA) samples. The introduction of LA units into the PGA skeleton reduced the difference in the degradation rate between the crystalline and amorphous regions, and they were simultaneously degraded in the early stage of degradation, leading to a degradation mechanism different from that of the PGA fiber.Casein (CS) and graphene oxide (GO) were employed for the fabrication of a casein/graphene oxide (CS/GO) aerogel by vacuum freeze drying. Fourier transform infrared spectroscopy, scanning electron microscopy, surface area and micropore analysis (BET), and thermogravimetric analysis were used to characterize the specific surface area, structure, thermal stability, and morphology of the CS/GO aerogel. The influence of experimental parameters such as the GO mass fraction in the aerogel, metering of the adsorbent, pH, contact time, and temperature on the adsorption capacity of the CS/GO aerogel on methylene blue (MB) was also investigated. According to Langmuir isotherm determination, the maximum removal rate of MB from the CS/GO aerogel was 437.29 mg/g when the temperature was 293 K and pH was 8. Through kinetic and thermodynamic studies, it is found that adsorption follows a pseudo-second-order reaction model and is also an exothermic and spontaneous process.