Linnettrue2847

The positivity resulted positive predictor from the social support (β = 0.714, p ˂ 0.001) and social support predicted the burnout (β = -0.270, p ˂ 0.005). The obsessive passion had a direct effect over burnout (β = 0.627, p ˂ 0.001). Developing negative commitments to sports could be an indicator of a greater risk of experiencing individual conflicts that lead to sports burnout.

Dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as anti-hyperglycemic agents that improve glycemic control in type 2 diabetic patients, either as monotherapy or in combination with other antidiabetic drugs.

A novel series of dihydropyrimidine phthalimide hybrids was synthesized and evaluated for their in vitro and in vivo DPP-4 inhibition activity and selectivity using alogliptin as reference. Oral glucose tolerance test was assessed in type 2 diabetic rats after chronic treatment with the synthesized hybrids ± metformin. Cytotoxicity and antioxidant assays were performed. Additionally, molecular docking study with DPP-4 and structure activity relationship of the novel hybrids were also studied.

Among the synthesized hybrids,

,

,

,

and

had stronger in vitro DPP-4 inhibitory activity than alogliptin. Moreover, an in vivo DPP-4 inhibition assay revealed that

and

have the strongest and the most extended blood DPP-4 inhibitory activity compared to alogliptin. In type 2 diabetic rats, hybrids

,

and

exhibited better glycemic control than alogliptin, an effect that further supported by metformin combination. Finally,

,

,

and

had the highest radical scavenging activity in DPPH assay.

Hybrids

,

and

are potent DPP-4 inhibitors which may be beneficial for T2DM treatment.

Hybrids 10g, 10i and 10e are potent DPP-4 inhibitors which may be beneficial for T2DM treatment.The Open Platform Communication Unified Architecture (OPC UA) protocol is a key enabler of Industry 4.0 and Industrial Internet of Things (IIoT). OPC UA is already accepted by the industry and its presence is expected to reach more and more fields, applications, and hierarchical levels. Advances within the latest specifications are providing the opportunity to extend the capabilities and the applicability of the protocol, targeting better performances in terms of data volumes, speed, availability, footprint, and security. Continuing previous researches focusing on the publish-subscribe (pub/sub) mechanism and real-time constraints, the current study aims to consider higher data-volumes, approach the multi-channel User Datagram Protocol (UDP)-based communication, and analyze the robustness of the developed mechanism in the context of long-term data transmission. Consequently, the research proposes to extend the applicability of the OPC UA in the context of image transmission. Although highly needed, the image transmission after processing is currently beyond the reach of OPC UA or other legacy industrial protocols, being considered as a separate fraction in the industrial environment. The concept and developments are applied considering both the end-of-line industrial manufacturing process in the automotive sector and the car-to-infrastructure communication. Without special hardware constraints, the obtained results are proven to be appreciable, opening various future perspectives for image transmission using OPC UA.The Chinese government has launched a digital health code system to detect people potentially exposed to the coronavirus 2019 (COVID-19) disease and to curb its spread. Citizens are required to show the health code on their smartphones when using public transport. However, many seniors are not allowed to use public transport due to their difficulties in obtaining health codes, leading to widespread debates about these unfair events. Traditionally, public perceptions and attitudes toward such unfair events are investigated using analytical methods based on interviews or questionnaires. This study crawled seven-month messages from Sina Weibo, the Chinese version of Twitter, and developed a hybrid approach integrating term-frequency-inverse-document-frequency, latent Dirichlet allocation, and sentiment classification. Results indicate that a rumor about the unfair treatment of elderly travelers triggered public concerns. Primary subjects of concern were the status quo of elderly travelers, the provision of transport services, and unfair event descriptions. Following the government's responses, people still had negative attitudes toward transport services, while they became more positive about the status quo of elderly travelers. These findings will guide government authorities to explore new forms of automated social control and to improve transport policies in terms of equity and fairness in future pandemics.Introduction Globally, the COVID-19 pandemic has affected older people disproportionately. Prior to the pandemic, some studies reported that telehealth was an efficient and effective form of health care delivery, particularly for older people. There has been increased use of telehealth and publication of new literature on this topic during the pandemic, so we conducted a scoping review and evidence synthesis for telehealth use in geriatric care to summarize learning from these new data. Methods We searched PubMed, Embase, and the World Health Organization's COVID-19 global research database for articles published between 1 January and 20 August 2020. We included 79 articles that met our inclusion criteria. The information collected has been synthesized and presented as descriptive statistics. Strengths, weaknesses, opportunities, and threats (SWOT) have also been discussed. Results The articles included in our review provide some evidence of effective provision of preventive, curative, and rehabilitative teley broader participation of older people, their caregivers, physicians and other health care providers, technology experts, and health managers.Green sensors are required for the realization of a sustainable economy. Biopolymer-derived composites are a meaningful solution to such a needing. Bacterial Cellulose (BC) is a green biopolymer, with significant mechanical and electrical properties. BC-based composites have been proposed to realize generating mechanoelectrical transductors. The transductors consist of a sheet of BC, impregnated of Ionic Liquids (ILs), and covered with two layers of Conducting Polymer (CP) as the electrodes. Charges accumulate at the electrodes when the transductor is bent. Generating sensors can produce either Open Circuit (OC) voltage or Short Circuit (SC) current. SMS 201-995 molecular weight In the paper, the OC voltage and SC current, generated from BC-based composites, in a cantilever configuration and subjected to dynamic deformation are compared. The influence of ILs in the transduction performance, both in the case of OC voltage and SC current is investigated. Experimental investigations of structural, chemical, and mechanoelectrical transduction properties, when the composite is dynamically bent, are performed.