Linkfrantzen9720

Non-alcoholic fatty liver disease (NAFLD) has a higher prevalence worldwide, and its pathogenesis is not clear. Genetic factors, dyslipidaemia and dysglycaemia have been proven to be associated with NAFLD. It has not been reported whether the triglyceride glucose index (TyG), which is estimated by triglyceride and fasting glucose, has a relationship with NAFLD in people from North China. selleck Whether the CDKAL1 gene rs10946398 SNP, which has been found to be associated with BMI, has a relationship with TyG and NAFLD is not clear.

We recruited a total of 1,760 subjects in this study, and we measured the clinical characteristics, abdominal ultrasound, and genotype of those participants.

The results showed that 527 (29.9%) subjects suffered from NAFLD, the TyG index was associated with NAFLD (OR=5.456, 95% CI (3.526~8.442)), and the CDKAL1 gene rs10946398 SNP has a relationship with NAFLD (OR=1.509, 95% CI (1.046~2.178)). The distribution of the C allele of rs10946398 was statistically significant at different levels of the TyG index.

We identified an association between the rs10946398 genotypes of CDKAL1 and NAFLD and the TyG index, and the TyG index was related to the risk of NAFLD.

We identified an association between the rs10946398 genotypes of CDKAL1 and NAFLD and the TyG index, and the TyG index was related to the risk of NAFLD.Ocular parasitic infections, which lead to significant morbidity and mortality in particular areas, have been shifting from endemic areas to other regions due to tourism, wars and migrations in recent years. This study aimed to review the parasitic factors related to the human eye and their geographical distribution, pathogenesis of the disease and the methods used in and studies conducted for its diagnosis. PubMed, MEDLINE and Google databases were researched and reviewed for relevant keywords in recent publications. Although such parasitic infections are rare in many parts of the world, they continue to be an important public health problem that affects human and animal health in places with poor health conditions. The distribution of ocular parasites and their spread to non-endemic areas are facilitated. The morbidity and mortality risks have been increasing due to the difficulties encountered by health personnel in the diagnosis of these parasitic infections. Defining them accurately and appropriately can save not only eyesight but also lives.

Microsporidia are opportunistic obligate intracellular pathogens which infect many vertebrate and invertebrate hosts. This study aimed at investigating all evidence about microsporidia infection in human and other vertebrate hosts in Turkey.

This study covered all prevalence studies, related to microsporidiosis in Turkey until April 2020, that were found in Web of Science, PubMed, Scopus, and ULAKBIM databases were considered in this meta-analysis. A total of 168 studies were identified in the systematic literature research. After the initial assessment, only 15 articles (12 humans and three other vertebrates) were included for meta-analysis. Data analysis was carried out using the Revman 5.3 (Review Manage 5.3) software.

With the evaluation of these studies, it was found that the prevalence of microsporidia in humans (n=6.707) and other vertebrate hosts (n=506) was 13.4% and 15.2%, respectively. The risk ratio in the patient groups was 2.87 compared to the control group [95% confidence interval (CI) 1.20-6.87, I2=87%, p<0.00001]. There was no difference between genders and parasite prevalence (95% CI 1.00-1.39, I2=18%, p=0.29). The prevalence of microsporidia was also found to be high in patients with diarrhea (95% CI 1.09-1.58, I2=86%, p=0.0001) and in immunosuppressed individuals (95% CI 1.86-3.70, I2=16%, p=0.31).

Although there are few studies on the prevalence of these parasites, the results of this meta-analysis provides extensive information about the current situation in Turkey.

Although there are few studies on the prevalence of these parasites, the results of this meta-analysis provides extensive information about the current situation in Turkey.

is a protozoan parasite that causes many deaths worldwide. It's cultivation in an in vitro culture setting contributes significantly to scientific studies. However, there are no laboratories in Turkey that cultivate

. Hence, the purpose of this study was to cultivate

.

Five

strains were used in our study and were kept frozen in liquid nitrogen tanks. These parasite strains were then thawed in a 37 °C water bath and transferred to the Albumax-complete medium that was previously prepared. After that, the petri dishes were placed in the chamber. For 30 seconds, a special gas mixture containing 5% CO

, 5% O

and 90% N

was added into the chamber which was placed in a 37 °C oven and left for incubation for 2 days. At the end of the incubation period, thin smear preparations were prepared from the medium, stained with Giemsa and examined using an immersion lens.

Examination of the smears revealed that trophozoite and schizont forms of all

isolates were present at a rate of 2% in

culture medium.

As a result of our study, the

culture of

was successfully developed. With this, several projects such as biological and chemical characteristics, pathogenicity, phenotypic and molecular-level drug sensitivities and parasite vaccination studies can be carried out more easily in our country.

As a result of our study, the in vitro culture of P. falciparum was successfully developed. With this, several projects such as biological and chemical characteristics, pathogenicity, phenotypic and molecular-level drug sensitivities and parasite vaccination studies can be carried out more easily in our country.

Since the identification of

subtypes (ST) in the last decade, much has been learned about the genetic diversity of

isolates in different populations, except pregnant women. The objective of this study is to investigate the genetic diversity of

in pregnant women and analyse some demographic factors.

The faecal samples from 100 pregnant women were collected at an Obstetrics and Gynecology Department in Muğla, Turkey. Thereafter,

positivity was detected by direct microscopy and culture. The positive cultures were subjected to DNA isolation, and the

barcode region was amplified with polymerase chain reaction. Next, the sequences were queried against GenBank nucleotide and

STs (18S) databases.

was detected in 14% (14 out of 100) of the faecal samples by culture and 10% (10 out of 100) of the samples by direct microscopy. Nine of

isolates (64.4%) were ST3, three (21.4%) were ST1 and two (14.2%) were ST2. Neither the demographic features nor the gastrointestinal symptoms were statistically related to

infection.

The findings in this study agreed with the most of the previous human studies that found ST3 as the most abundant genotype. This study reported the frequency of

in pregnant women and highlighted the importance of comprehensive studies with more cases of

during pregnancy.

The findings in this study agreed with the most of the previous human studies that found ST3 as the most abundant genotype. This study reported the frequency of Blastocystis in pregnant women and highlighted the importance of comprehensive studies with more cases of Blastocystis during pregnancy.

Leishmaniasis is an important parasitic disease in many countries, including ours. A variety of drugs are currently used for its treatment. However, certain side effects of these drugs, such as teratogenicity, hepatotoxicity and nephrotoxicity, have been reported in some patients. The goal of this research is to determine the antileishmanial effects of eight different previously synthesised compounds containing Schiff and Mannich bases (morpholine) against

promastigotes by the liquid microdilution method utilising alamarBlue.

Compounds containing Schiff bases (a-d) and both Schiff bases and morpholine rings (e-h) were tested. Compounds were diluted in the range of 20000-39 μg/mL.

promastigotes were added to the wells, which were then incubated at 27 °C. The proliferation of Leishmania promastigotes was evaluated after 24, 48 and 72 hours.

In this study, compounds b, c and d (MIC values 156 μg/mL, 78 μg/mL and 156 μg/mL) were found to be effective against

promastigotes, whereas compound f (MIC >20000 μg/mL) was found to be more the most ineffective compound.

These compounds may be potential drug candidates for the treatment of leishmaniasis. According to the results, there is a need for further studies, such as in vivo experimental animal models and

amastigote macrophage cultures for compounds showing antileishmanial effects.

These compounds may be potential drug candidates for the treatment of leishmaniasis. According to the results, there is a need for further studies, such as in vivo experimental animal models and ex vivo Leishmania amastigote macrophage cultures for compounds showing antileishmanial effects.

Coconut oil and its derivatives are widely thought to kill head lice by occlusion and asphyxiation. There is no evidence in support of coconut derivative-based products sold to treat pediculosis. This study was designed to test one such product.

This was an open-label clinical study in 31 people. The treatment was shampoo containing 1% fractionated coconut oil. Treatment was given on day 0 and day 8. Efficacy was measured using a detection comb on day 1, day 8 and day 16 after the first treatment. The trial was registered in the current controlled trials database, under number ISRCTN79136319.

The first application of the product eliminated the lice from 7/31 participants, and 12/31 (38.7%) people had no lice at the end of the study. Lice of all development stages were found post treatment at all assessments on one or more participants. This indicates that the treatment failed to kill all stages of the life cycle of head lice.

Two applications of the modified coconut shampoo were not effective at killing head lice or their eggs. The results confirm other studies that show little intrinsic activity in vegetable oils and modified oils. Most of the activity in shampoos is probably due to other product components, such as high levels of detergents.

Two applications of the modified coconut shampoo were not effective at killing head lice or their eggs. The results confirm other studies that show little intrinsic activity in vegetable oils and modified oils. Most of the activity in shampoos is probably due to other product components, such as high levels of detergents.

Cystic echinococcosis (CE) is a zoonotic disease, which leads to morbidity and mortality worldwide. This study aimed to retrospectively evaluate the presence of anti-

immunoglobulin G (IgG) antibodies, which were detected by indirect fluorescent antibody test in the samples that were transferred to the Microbiology Laboratory of University of Health Sciences Turkey, Diyarbakır Gazi Yaşargil Training and Research Hospital with the pre-diagnosis of CE. Moreover, gender differences with respect to positivity rates of anti-

IgG antibodies were investigated.

Anti-

IgG antibodies, which were detected in the samples of cases with the pre-diagnosis of CE between January 2014 and December 2017, were retrospectively evaluated. Gender difference with respect to positivity rates was investigated by applying the chi-square test in cases with positive anti-

IgG antibodies.

Out of the 829 serum samples, 222 (26.7%) were found to be positive for

IgG antibodies, among which 40 (27.2%), 56 (25.5%), 51 (23.3%) and 75 (30.