Lindgreenlynggaard1944
To compare anterior chamber depth (ACD), keratometry (K1, K2), central corneal thickness (CCT), and axial length (AL) measured by four different devices.
150 eyes qualified for cataract surgery were included in the study. Four devices IOL Master 500, OCT CASIA2, Dual Scheimpflug Analyzer Galilei G6, and Quantel Compact Touch ultrasound biometer, were compared. The agreement of measurements between the devices was evaluated by the Bland-Altman method.
ACD was significantly different for Ultrasound and IOL Master 3±0.33 3.12±0.42 respectively Interclass correlation ecoefficiency (ICC)0.69 (95% confidence interval (CI) 0.62; 0.76) p <0.001. A significant difference was observed between Casia and IOL while measuring K1, 43.5±1.7 vs. 43.61±1.56 ICC0.84 (95%CI 0.79; 0.87) and ACD parameters 2.65±0.45 vs. 3.12±0.42 ICC 0.68 (95% 0.6; 0.75) and K2 42.51±1.62 vs. 44.57±1.59 ICC; 0.83 (95%CI0.78; 0.87) p <0.001. Similarly, measurements obtained by Casia, and Galilei were also different K1 43.5±1.7 ICC0.7 (95%CI0.62; 0.76), CCT 546.35±34.75 vs. 566.73±37.92 ICC0.88 (95%CI0.84; 0.9) p <0.001. Differences between Galilei and IOL master were not significant p values from 0.175 to 0.999 ICC 0.8 (95%CI0.75; 0.85) to ICC 0.94 (95%CI0.92; 0.95).
The measurements obtained from Casia, and Ultrasound were significantly different and not interchangeable except for IOL master and Galilei.
The measurements obtained from Casia, and Ultrasound were significantly different and not interchangeable except for IOL master and Galilei.
Stapes surgery for otosclerosis occasionally requires revision due to recurrent or persistent conductive hearing loss (CHL). This study examines outcomes after revision stapes surgery.
Retrospective review.
Single tertiary neurotology center.
Patients undergoing revision stapes surgery for otosclerosis from 2008 to 2017 were reviewed. Postoperative air-bone gaps (ABGs) were the primary outcome measure.
During the study period, 150 patients underwent revision stapes surgery. One hundred patients (67%) had gradually progressive recurrent CHL; 16 (11%), sudden recurrent CHL; 13 (9%), persistent CHL; and 21 (14%), no CHL. For 129 patients with CHL, the mean ABG improved from 23.7 to 9.3 dB (
< .0005). The most common intraoperative findings for these patients were prosthesis displacement with incus necrosis (38%) or without it (43%), normal anatomy with seemingly good prosthesis placement (6%), and abundant scar tissue (6%). Patients with recurrent hearing loss achieved lower mean ABGs than patients with persistent hearing loss (8.8 vs 13.2 dB,
= .02). There were no associations between onset pattern of CHL or intraoperative findings and hearing outcomes (
> .05). Four patients (2.7%) developed sensorineural hearing loss after revision, defined as an increase in bone conduction pure tone average ≥15 dB, all of whom had previous replacement of a malpositioned prosthesis.
Revision stapes surgery confers significant improvement in hearing for patients with persistent and recurrent CHL, although patients with persistent CHL after initial surgery see less improvement with revision.
Revision stapes surgery confers significant improvement in hearing for patients with persistent and recurrent CHL, although patients with persistent CHL after initial surgery see less improvement with revision.The changes in δ13CH4 and δ12C1H32H during sulphate-dependent anaerobic oxidation of methane (AOM) were described using dynamic modelling. The batch sulphate-dependent AOM at the nearly linear dynamics of methane oxidation with different enriched cultures originating from three marine sediments was simulated. The traditional Rayleigh equation for carbon and hydrogen stable isotopes in methane was derived from the basic dynamic isotope equation. The general and reduced models, taking into account the reaction stoichiometry and based on balances of chemical elements and their isotopes, describes a redistribution of stable isotope values in the sulphate-dependent AOM process. It was shown that AOM is the first and rate-limiting step in the whole AOM + SR (sulphate reduction) process. The different fractionation factors of carbon and hydrogen isotopes in methane were obtained for three marine sediments. It was concluded that during incubation the highest concentration of methanotrophic archaea might be responsible for the lowest fractionation factors of stable isotopes of carbon and hydrogen in methane. The interpretation of this phenomenon was suggested. Different concentrations of methanotrophic archaea can lead to variations of isotope fractionation factors.When it originated in the late 19th century, psychometrics was a field with both a scientific and a social mission Psychometrics provided new methods for research into individual differences and at the same time considered these methods a means of creating a new social order. In contrast, contemporary psychometrics-because of its highly technical nature and its limited involvement in substantive psychological research-has created the impression of being a value-free discipline. In this article, we develop a contrasting characterization of contemporary psychometrics as a value-laden discipline. We expose four such values that individual differences are quantitative (rather than qualitative), that measurement should be objective in a specific sense, that test items should be fair, and that the utility of a model is more important than its truth. Our goal is not to criticize psychometrics for supporting these values but rather to bring them into the open and to show that they are not inevitable and are in need of systematic evaluation.Done well, ward rounds (WRs) promote effective, safe care and collaboration; but WR quality varies. An improvement-focused appreciative inquiry (AI) into a large intensive care unit's WR practices identified a pivotal axis of collaboration between the most senior medical role (the consultant) and the bedside nurse (BSN). This paper examines that axis of interprofessional collaboration (IPC) to deepen understanding of its implications. Data included ethnographic observations, interviews, and co-constructed AI with groups of staff. Four key concepts emerged from cyclical interpretive analysis "need," "presence," "ability" and "willingness." BSNs and consultants needed the interprofessional WR to enable their work; WR effectiveness was affected by whether they were both present, then able and willing to participate in IPC. BSN presence was necessary for effective and efficient IPC between these key roles. Indirect contributions, based on prior exchanges with colleagues or through written notes, reduced the joint problem-solving through discussion and negotiation that characterizes IPC to less efficient asynchronous interprofessional coordination. Factors affecting "presence," "ability" and "willingness" are discussed alongside potential mitigations and acknowledgment of asymmetric power. Appreciative examination of interprofessional WRs identified mechanisms supporting and undermining effective WR IPC and the centrality of consultants' and BSNs' collaboration.
The relationship between the disease activity of ulcerative colitis and fatigue is unclear. We investigated how reaching deep remission versus remaining in active disease influenced the severity of fatigue.
We included 149 consecutive patients in a longitudinal study. Patients were re-examined after 3 months of conventional treatment and dichotomized into A Active disease or B Deep remission. The Partial Mayo Score (PMS) was recorded in all patients. Fatigue was rated using the fatigue visual analog scale (fVAS), Fatigue Severity Scale (FSS), and Short Form-36 Vitality Subscale (SF-36vs). A control group of 22 age and sex-matched healthy subjects were included as controls for patients reaching deep remission.
After 3 months there were no significant differences in fVAS, FSS and SF-36vs scores in patients with active disease compared to patients reaching deep remission, when adjusting for baseline fatigue scores. Patients in remission based on MES-UC scores had no significant reduction in fatigue scores, inflammation influence fatigue in UC.Whom do individuals blame for intergroup conflict? Do people attribute responsibility for intergroup conflict to the in-group or the out-group? Theoretically integrating the literatures on intergroup relations, moral psychology, and judgment and decision-making, we propose that unpacking a group by explicitly describing it in terms of its constituent subgroups increases perceived support for the view that the unpacked group shoulders more of the blame for intergroup conflict. Five preregistered experiments (N = 3,335 adults) found support for this novel hypothesis across three distinct intergroup conflicts the Israeli-Palestinian conflict, current racial tensions between White people and Black people in the United States, and the gender gap in wages in the United States. Our findings (a) highlight the independent roles that entrenched social identities and cognitive, presentation-based processes play in shaping blame judgments, (b) demonstrate that the effect of unpacking groups generalizes across partisans and nonpartisans, and (c) illustrate how constructing packed versus unpacked sets of potential perpetrators can critically shape where the blame lies.Background The objective of this study was to evaluate sex differences in the incidence and risk of ankle-foot complex (AFC) stress fractures among U.S. military personnel, which could assist in developing management strategies as females assume a greater role in U.S. military operations. Materials and Methods The Defense Medical Epidemiology Database was used to identify all diagnosed AFC stress fractures in military personnel from 2006 to 2015. Cumulative incidence of AFC stress fractures was calculated and compared by year, service branch, and military rank. Sex differences in the risk of AFC stress fractures by occupation were examined, and integrated (i.e., male and female) occupations were compared with nonintegrated (i.e., male only) occupations. Results A total of 43,990 AFC stress fractures were identified. The overall incidence rate was 2.76 per 1,000 person-years (p-y) for males and 5.78 per 1,000 p-y for females. Females consistently had higher incidence of AFC stress fractures across all subgroups, particularly among enlisted personnel. learn more Female enlisted service members had the highest risk of AFC stress fractures in aviation (relative risk [RR] = 5.74; 95% confidence interval [CI] 4.80-6.87) and artillery/gunnery (RR = 5.15; 95% CI 4.62-5.75) occupations. Females in integrated occupations had significantly higher rates of AFC stress fractures than males in both integrated and nonintegrated occupations (i.e., special forces, infantry, and mechanized/armor). Conclusions Females in the U.S. military have a higher risk of AFC stress fractures than males. As integration of females into previously sex-restricted occupations continues, focused prevention efforts may be needed to reduce injury burden and maximize medical readiness.Background Endogenous and synthetic cannabinoids have been shown to induce cancer cell death through the accumulation of the sphingolipid, ceramide (Cer). Recently, we have demonstrated that Cer accumulation enhances the induction of immunogenic cell death (ICD). Objectives The primary objective of this study was to demonstrate that (±) 5-epi CP 55,940 (5-epi), a by-product of the chemical synthesis of the synthetic cannabinoid CP 55,940, induces ICD in colorectal cancer (CRC) cells, and that modulation of the sphingolipid metabolic pathway through inhibition of the sphingosine kinases (SphKs) enhances these effects. Methods A cell culture model system of human CRC cell lines was employed to measure the cell surface and intracellular production of markers of ICD. The effects of 5-epi, alone and in combination with SphK inhibitors, on production of Cer through the de novo sphingolipid synthesis pathway were measured by Liquid Chromatography - Tandem Mass Spectrometry (LC/MS/MS)-based sphingolipidomic analysis.
