Lindgaardgraversen2755

Response inhibition is sensitive to unexpected changes in the environment triggered by emotional stimuli. Whereas the impact of visual material on inhibition has been widely documented, the attention on the influence of olfactory stimuli has been neglected. Here, we examined the effect of pleasant (orange), unpleasant (trimethyloxazole), and control (clean air) odour primes in a stop-signal task. Twenty-five participants had to elicit or inhibit reach-to-press actions which allowed to examine the olfactory influences on both the planning (release phase) and the on-line control (reaching phase) of responses. Additionally, we manipulated the distance between the initial hand position and the target to be pressed (10 vs. 20 vs. 30 cm). The pleasant (vs. control) odour impaired inhibition, as reflected in slower stop-signal reaction times and higher release errors, indicating greater mobilisation of inhibitory resources by pleasant stimuli. Further, faster release responses were triggered by pleasant and unpleasant primes, supporting the idea of perceptual prioritisation of emotional (vs. non-emotional) stimuli. The olfactory manipulation did not affect the reaching phase of the responses. Instead, the distance manipulation modulated the reaching but not the release phase. These results extend the sparse literature on the influences of odour stimuli on response inhibition.We describe feedforward neuromuscular control during a maximal jump landing/cutting task among groups of chronic ankle instability (CAI), coper, and uninjured control subjects. Sixty-six volunteers participated (22 CAI, 22 copers, and 22 uninjured controls). The subjects completed five trials of a maximal jump landing/cutting manoeuvre. Three-dimensional ground reaction force, lower-extremity joint angles, and activation of eight muscles were collected from 150 ms prelanding to initial contact. Functional analyses of variance (FANOVA) were used to evaluate between-group differences for these outcome variables. Compared to uninjured controls, both CAI patients and copers demonstrated altered sagittal lower-extremity movements. However, only copers exhibited unique kinematic alterations in frontal lower-extremity kinematics in the ankle and hip joints. While CAI patients demonstrated decreased most of lower-extremity EMG activation, copers displayed increased EMG activation during prelanding. Current data suggest that both CAI patients and copers demonstrated alterations in feedforward neuromuscular control prior to initial contact during a demanding jump landing/cutting task. Altered movement strategies during prelanding were observed in both proximal (e.g., knee and hip) and distal (e.g., ankle) joints in CAI patients and copers, while copers presumably had more protective jump landing/cutting movement strategies than CAI patients.Introduction People with hemophilia (PWH) commonly experience acute and chronic musculoskeletal pain during childhood and young adulthood, but their treatment is often inadequate.Areas covered From 1 September 2020 to 15 April 2021, authors performed a literature search in PubMed and the Cochrane Library using 'hemophilia AND pain' as keywords. Authors found 1082 articles, 51 of which were chosen because we considered them to be intimately connected with the topic of this report. Multimodal pain treatment, including multimodal analgesia, physical and rehabilitation medicine (PRM), and psychological therapies (imagery or relaxation, hypnosis), is currently the most recommended treatment for PWH. In acute hemarthrosis, in addition to hematologic treatment and joint aspiration, paracetamol/acetaminophen should be prescribed if the pain is mild, metamizole if the pain is moderate, and soft opioids (codeine or tramadol) if the pain is severe. In cases of chronic musculoskeletal pain due to hemophilic arthropathy, paracetamol/acetaminophen, COX-2 inhibitors, PRM, intra-articular injections of some drugs (corticosteroids, hyaluronic acid, platelet-rich plasma, mesenchymal stem cells), radiosynovectomy and behavioral therapies are advised.Expert opinion Management of musculoskeletal pain in children and young adults with hemophilia should employ multimodal pain treatment (multimodal analgesia, PRM, and psychological strategies).

An inter- and intra-observer agreement study.

In recent years, vertebroplasty and kyphoplasty have been widely used in treating osteoporotic vertebral compression fractures (OVCF) though the clinical efficacy of them is still controversial. However, there are also inevitable complications, first and foremost is bone cement leakage (BCL). Yeom classification is commonly used to evaluate BCL. The objective of this study is to assess its reliability and reproducibility, and to explore its clinical application value.

All 58 patients with BCL following vertebroplasty/kyphoplasty were involved. Six spine surgeons were selected to be evaluators as they were unaware of the identity of the patients and the treatment they received. They classified BCL according to Yeom system, we used kappa (K) to assess the inter- and intra-observer agreement. After 12 weeks, we repeated the analysis.

The inter-observer reliability of Yeom classification was substantial with

value of 0.71 (1st assessment) and 0.73 (2nd assessment). The intra-observer reproducibility of Yeom classification was near perfect with

value of 0.88.

Yeom classification system has substantial inter-observer reliability and near perfect intra-observer reproducibility in BCL following vertebroplasty/kyphoplasty, which can be widely used in clinical care as an appropriate instrument for early observation, mechanism and severity cognition, and prognosis predicting of BCL. Besides, the adding of type M (the mixed type) may improve the classification.

Yeom classification system has substantial inter-observer reliability and near perfect intra-observer reproducibility in BCL following vertebroplasty/kyphoplasty, which can be widely used in clinical care as an appropriate instrument for early observation, mechanism and severity cognition, and prognosis predicting of BCL. Besides, the adding of type M (the mixed type) may improve the classification.

There is a growing need for biomarkers to predict therapeutic outcome in Crohn's disease (CD).

The aim was to evaluate whether NLR (neutrophil-to-lymphocyte ratio), PLR (platelet-to-lymphocyte ratio), ELR (eosinophil-to-lymphocyte ratio), and ENLR (eosinophil*neutrophil-to-lymphocyte ratio), could be prognostic biomarkers of endoscopic response (ER) when starting biologics.

Patients with CD who started biologics were enrolled. Multivariate analysis was used to evaluate whether NLR, PLR, ELR and ENLR at baseline and at w12 could predict ER (Simple Endoscopic Score for Crohn's disease [SES-CD] ≤2 or SES-CD≤2 and Rutgeerts i0-i1) after 52weeks of treatment. Area under the curve (AUC) was calculated to find the cutoffs.

107 patients were included. Patients who achieved ER had significantly lower baseline NLR (p=0.025), ELR (p=0.013), and ENLR (p=0.020) compared with those without ER; results after 12weeks of treatment for ELR (p=0.006) and ENLR (p=0.003). AUC was 0.64 (p=0.003), 0.67 (p=0.006) and 0.65 (p=0.014) for NLR, ELR and ENLR.

Low NLR, ELR and ENLR can predict ER and could be used in clinical practice for a better management of CD patients.

Low NLR, ELR and ENLR can predict ER and could be used in clinical practice for a better management of CD patients.In many situations, engaging cognitive control is required to override automatic responses and to behave in an adaptive manner. However, cognitive control is also effortful and costly which makes it aversive. A fundamental question is how individuals decide to engage or not in cognitive control based on the costs of this effort and the motivation to achieve the goals. In the present study, we explored the hypothesis that affective states can influence this decision by changing participants' subjective experiences during the task. Participants performed a conflict task (arrow priming) and judged their feeling of difficulty after each trial. Affective states were induced by presenting emotional faces (happy, fearful or neutral) at the beginning of each trial. We found that participants subjectively judged happy trials as easier even though they objectively made more errors in this condition. Follow-up analyses revealed that participants engaged less cognitive control with happy than with neutral or fearful faces. We conclude that affective states influence the recruitment of cognitive control and associated metacognitive experiences.Depression is characterised by attentional bias to emotional information and dysregulated autonomic reactivity. Despite its relevance to understanding depressive mechanisms, the association between attentional bias and autonomic reactivity to emotional information remains poorly characterised. This study compared behavioural and autonomic responses to emotional images in 32 participants in whom subclinical depressive symptomatology was quantified using the Beck Depression Inventory. Pairs of emotional and neutral images (unpleasant-neutral, U-N; pleasant-neutral, P-N; neutral-neutral, N-N) were presented while attentional indices (eye movements) and autonomic activity (skin conductance responses, SCRs; heart rate, HR) were recorded. Results showed that all recorded ocular parameters indicated a preferential orientation and maintenance of attention to emotional images. SCRs were associated with a valence effect on fixation latency lower fixation latency to pleasant stimuli leads to lower SCRs whereas the opposite was observed for unpleasant stimuli. Curzerene clinical trial Finally, stepwise linear regression analysis revealed that latency of fixation to pleasant images and scores of depression predicted SCRs of participants. Thus, our research reveals an association between autonomic reactivity and attentional bias to pleasant information, on the one hand, and depressive symptomatology on the other. Present findings therefore suggest that depressive individuals may benefit from attention training towards pleasant information in association with autonomic biofeedback procedures.Unbalanced bilinguals react differently to emotional stimuli in their first (L1) and second (L2) language. However, the size and direction of the emotion difference varies across emotions and tasks, so that its causes are controversial. Therefore, we investigated if the attentional resources bilinguals allocate to emotion processing moderate their language-dependent emotions. In two experiments, we crossed language and emotion regulation. Study 1 compared effects of distraction and concentration on bilingual emotion-word valence ratings. Study 2 induced positive emotion-focused rumination (or not) prior to a simulated, video-based online-dating activity. It measured emotional attraction to dating candidates speaking the participant's L1 or L2 in pupillary, eye-fixation and self-report responses. The studies found reduced L2 emotions when emotion processing was distracted or when its level was low to start with. Yet, if bilinguals concentrated or had ruminated on their emotions, their self-reported and physiological emotionality was comparable or even stronger in L2, relative to L1.