Lindeforbes4798

A 26-year-old young male presented with recent onset hypertension and left sided varicocele. On physical examination his blood pressure was elevated and varicoceles were visible. On evaluation with computed tomography of abdomen, a large left sided para-aortic mass was seen. His 24 hour urinary metanephrines and normetanephrines levels were within normal limits. Subsequently, the mass was excised Tumor was excised completely after carefully dissecting it from left kidney and final histopathology revealed paraganglioma and postoperatively varicoceles disappeared.Objectives To describe injuries associated with netball and risk factors for lower limb injuries. Design Prospective study. In the preseason, risk factors were investigated using self-report questionnaires and physical measurements. During the season, injuries were reported using a standardised report, verified by follow-up phone calls. Player training and game hours were recorded. Setting Australian community netball club. Participants 269 players from 9 divisions, aged 7-42 years. Main outcome measures Injury incidence rates per 1000 exposure hours were calculated. The most common mechanism, nature and consequence of injury were determined from frequencies. Logistic regression was used to identify predictors of lower limb injury and determine adjusted odds ratios for each risk factor. Results 169 injuries occurred with a rate of 13.8/1000 exposure hours (95% CI 11.8-16.0), majority (60%) to the lower limb. The most frequent injury mechanisms were collisions (28%) and awkward landings (27%), nature was 'Inflammation/swelling' (32%) and consequence was 'unable to continue playing/training' (50%). Previous history of injury (OR 6.9, 95% CI 3.7-13.0) and age greater than 13.5 years (OR 3.1, 95% CI 1.6-5.9) were significant risk factors for a season lower limb injury. Conclusion Injury rates in this community netball club were high. Results suggest that further research regarding the implementation and effectiveness of injury prevention programs for community netballers is required.Objective First-line chemotherapy in metastatic neuroendocrine carcinomas (NEC) is based on etoposide and platinum. However, there is no standard concerning second-line treatment. The objective of this study was to evaluate efficacy and tolerance of dacarbazine or temozolomide in metastatic digestive NEC as post first-line treatment. Material and methods This study included patients with a metastatic NEC of digestive or unknown primary site. All patients received platinum-etoposide as first-line chemotherapy. Primary endpoint was progression-free survival (PFS). Secondary endpoints were clinical/morphological responses, toxicity, and overall survival (OS). Results 27 patients were included 17 received dacarbazine and 10 temozolomide as post-first line treatments. Median PFS was 3.0 (95%CI [2.2;3.7]) months. selleck kinase inhibitor There was no significant difference between dacarbazine and temozolomide on PFS. Clinical and morphological responses were found in 46% and 33% of patients, respectively. Median OS was 7.2 (95%CI [2.2;12.2]) months. The toxicity profile was that expected with such treatments. Conclusion This study confirms a poor prognosis of metastatic NEC during post first-line treatment. LV5FU2-Dacarbazine or temozolomide-capecitabine chemotherapies allow a temporary clinical response for half of patients and/or a morphological response for a third of patients.Introduction Leonbergers are large-breed dogs believed to be predisposed to dilated cardiomyopathy, yet the normal echocardiographic measurements of these dogs are unknown. The aim of this study was to describe echocardiographic findings and propose breed-specific reference intervals (RIs) for Leonbergers. Animals A total of 42 clinically healthy dogs were involved in this study. Materials and methods This study was designed as a cross-sectional study of 42 Leonberger dogs undergoing complete transthoracic echocardiographic studies at a national show. Reference intervals were determined using robust method with bootstrapping. The effects of age, sex, and body weight (BW) on linear and volumetric dimensions were evaluated by regression analysis. Intra- and interobserver variability were evaluated by coefficient of variation from 10 of the studies. Results There were significant linear correlations with BW for many of the cardiac variables evaluated. However, despite the statistical significance, most regression equations had small slopes, necessitating large changes in BW for small changes in two-dimensional echocardiographic variables. As such, this study resulted in breed-specific RIs irrespective of BW. Trace mitral insufficiency (n = 18), trace aortic insufficiency (n = 15), or both (n = 1) was identified in 81% of dogs in this population. Coefficients of variation were less then 9% for all two-dimensional, volumetric, and motion mode measurements. Conclusions This study describes echocardiographic findings and provides RIs, which may be useful in echocardiographic evaluations of Leonbergers and may aid in early identification of heart disease within the breed.Objectives To describe injuries associated with netball and risk factors for lower limb injuries. Design Prospective study. In the preseason, risk factors were investigated using self-report questionnaires and physical measurements. During the season, injuries were reported using a standardised report, verified by follow-up phone calls. Player training and game hours were recorded. Setting Australian community netball club. Participants 269 players from 9 divisions, aged 7-42 years. Main outcome measures Injury incidence rates per 1000 exposure hours were calculated. The most common mechanism, nature and consequence of injury were determined from frequencies. Logistic regression was used to identify predictors of lower limb injury and determine adjusted odds ratios for each risk factor. Results 169 injuries occurred with a rate of 13.8/1000 exposure hours (95% CI 11.8-16.0), majority (60%) to the lower limb. The most frequent injury mechanisms were collisions (28%) and awkward landings (27%), nature was 'Inflammation/swelling' (32%) and consequence was 'unable to continue playing/training' (50%).