Levesquejacobs1824

Skin-like energy devices can be conformally attached to the human body, which are highly desirable to power soft wearable electronics in the future. Here, a skin-like stretchable fuel cell based on ultrathin gold nanowires (AuNWs) and polymerized high internal phase emulsions (polyHIPEs) scaffolds is demonstrated. The polyHIPEs can offer a high porosity of 80% yet with an overall thickness comparable to human skin. Upon impregnation with electronic inks containing ultrathin (2 nm in diameter) and ultrahigh aspect-ratio (>10 000) gold nanowires, skin-like strain-insensitive stretchable electrodes are successfully fabricated. With such designed strain-insensitive electrodes, a stretchable fuel cell is fabricated by using AuNWs@polyHIPEs, platinum (Pt)-modified AuNWs@polyHIPEs, and ethanol as the anode, cathode, and fuel, respectively. The resulting epidermal fuel cell can be patterned and transferred onto skin as "tattoos" yet can offer a high power density of 280 µW cm-2 and a high durability (>90% performance retention under stretching, compression, and twisting). The results presented here demonstrate that this skin-thin, porous, yet stretchable electrode is essentially multifunctional, simultaneously serving as a current collector, an electrocatalyst, and a fuel host, indicating potential applications to power future soft wearable 2.0 electronics for remote healthcare and soft robotics.

Gastrin-17 (G-17) and Helicobacter pylori (Hpylori) antibody are widely used in the screening of gastric diseases, especially in gastric cancer. In this study, we aimed to evaluate the value of G-17 and Hpylori antibody in gastric disease screening.

Healthy males and females (1368 and 1212, respectively) aged between 21-80years were recruited for the study. Serum G-17 value was measured using ELISA, and Hpylori antibodies were measured using Western blotting. Statistical analyses were performed using the chi-square, Mann-Whitney U, and Kruskal-Wallis H tests.

Serum G-17 level was higher in the Hpylori-positive group than in the negative group. Serum G-17 level was higher in the type 1 Hpylori-positive group than in the type 2 Hpylori-positive group. Further, serum G-17 level was higher in females than in males and showed significant differences among different age-groups, with changes in trend proportional to the age. The positive rate of Hpylori infection in all the subjects was 58.29% and did not show a significant difference between males and females. However, it showed significant differences among different age-groups, with the changing trend proportional to the age.

Analysis of serum G-17 level and Hpylori antibody typing is valuable in gastric disease screening. Every laboratory should establish its own reference interval for G-17 level.

Analysis of serum G-17 level and H pylori antibody typing is valuable in gastric disease screening. Every laboratory should establish its own reference interval for G-17 level.Bioconjugation methods using visible-light photocatalysis have emerged as powerful synthetic tools for the selective modification of biomolecules under mild reaction conditions. However, the number of photochemical transformations that allow successful protein bioconjugation is still limited because of the need for stringent reaction conditions. Herein, we report that a newly developed water-compatible fluorescent photosensitizer QPEG can be used for visible-light-induced cysteine-specific bioconjugation for the installation of QPEG by exploiting its intrinsic photosensitizing ability to activate the S-H bond of cysteine. The slightly modified QCAT enables the effective photocatalytic cysteine-specific conjugation of biologically relevant groups. The superior reactivity and cysteine selectivity of this methodology was further corroborated by traceless bioconjugation with a series of complex peptides and proteins under biocompatible conditions.How modification of gene expression generates novel traits is key to understanding the evolutionary process. We investigated the genetic basis for the origin of the piscine gas bladder from lungs of ancestral bony vertebrates. Distinguishing these homologous organs is the direction of budding from the foregut during development; lungs bud ventrally and the gas bladder buds dorsally.

Macromolecular peaks underlying metabolite spectra influence the quantification of metabolites. Therefore, it is important to understand the extent of contribution from macromolecules (MMs) in metabolite quantification. However, to model MMs more accurately in spectral fitting, differences in T

relaxation times among individual MM peaks must be considered. Characterization of T

-relaxation times for all individual MM peaks using a single inversion recovery technique is difficult due to eventual contributions from metabolites. On the contrary, a double inversion recovery (DIR) technique provided flexibility to acquire MM spectra spanning a range of longitudinal magnetizations with minimal metabolite influence. Thus, a novel method to determine T

-relaxation times of individual MM peaks is reported in this work.

Extensive Bloch simulations were performed to determine inversion time combinations for a DIR technique that yielded adequate MM signal with varying longitudinal magnetizations while minimizing metabolite contributions. INCB39110 concentration MM spectra were acquired using DIR-metabolite-cycled semi-LASER sequence. LCModel concentrations were fitted to the DIR signal equation to calculate T

-relaxation times.

T

-relaxation times of MMs range from 204 to 510 ms and 253 to 564 ms in gray- and white-matter rich voxels respectively at 9.4T. Additionally, concentrations of 13 MM peaks are reported.

A novel DIR method is reported in this work to calculate T

-relaxation times of MMs in the human brain. T

-relaxation times and relaxation time corrected concentrations of individual MMs are reported in gray- and white-matter rich voxels for the first time at 9.4T.

A novel DIR method is reported in this work to calculate T1 -relaxation times of MMs in the human brain. T1 -relaxation times and relaxation time corrected concentrations of individual MMs are reported in gray- and white-matter rich voxels for the first time at 9.4T.

Preoperative differentiation of primary central nervous system lymphoma (PCNSL) from glioblastoma (GBM) is important to guide neurosurgical decision-making.

To validate the generalization ability of radiomics models based on multiparametric-MRI (MP-MRI) for differentiating PCNSL from GBM.

Retrospective.

In all, 240 patients with GBM (n = 129) or PCNSL (n = 111).

3.0T scanners (two vendors). Sequences fluid-attenuation inversion recovery, diffusion-weighted imaging (DWI), and contrast-enhanced T

-weighted imaging (CE-T

WI). link2 Apparent diffusion coefficients (ADCs) were derived from DWI.

Cross-vendor and mixed-vendor validation were conducted. In cross-vendor validation, the training set was 149 patients' data from vendor 1, and test set was 91 patients' data from vendor 2. In mixed-vendor validation, a training set was 80% of data from both vendors, and the test set remained at 20% of data. Single and multisequence radiomics models were built. The diagnoses by radiologists with 5, 10, and 20 yearcompared to the radiologists alone.

4 TECHNICAL EFFICACY STAGE 2.

4 TECHNICAL EFFICACY STAGE 2.In this special issue of the American Journal of Medical Genetics, Part C, we explore the ever-expanding field of Ophthalmic Genetics. The eye is unique among organs for its accessibility to physical examination, permitting exploration of every tissue by slit lamp microscopy, ophthalmoscopy, and imaging including color and autofluorescent photography, ultrasound, optical coherence tomography (OCT), electrophysiology, and adaptive optics confocal and scanning laser ophthalmoscopy. This accessibility permits a variety of surgical and nonsurgical treatments, including the first FDA-approved gene therapy, voretigene neparvovec-rzyl for RPE65-associated Leber Congenital Amaurosis. In this issue, we sought to provide a survey highlighting how heritable ophthalmic disorders are recognizable and accessible to clinical geneticists as well as ophthalmologists.Our experiments have previously demonstrated that rutin (RUT) can improve myocardial damage caused by pirarubicin (THP). However, the underlying molecular mechanisms remain uncertain. In this study, we developed an microRNA (miRNA) chip by replicating the rat model of THP-induced myocardial injury and identified miR-22-5p and the RAP1-member of RAS oncogene family/extracellular regulated protein kinases (RAP1/ERK) signaling pathway as an object of study. Also, in vivo experiments demonstrated that THP caused abnormal changes in the electrocardiogram, cardiac function, and histomorphology in rats (P  less then  .01). link3 THP also reduces the expression of miR-22-5p (P  less then  .01) and increases the levels of RAP1/ERK signaling pathway-related proteins (P  less then  .01, P  less then  .05). RUT significantly improved THP-induced myocardial damage (P  less then  .01), increased the expression of miR-22-5p (P  less then  .01), and decreased the levels of RAP1/ERK signaling pathway-related proteins (P  less then  .01, P  less then  .05). In vitro studies confirmed that Rap1a is one of the target genes of miR-22-5p. miR-22-5p overexpression in cardiomyocytes can affect the RAP1/ERK pathway and reduce reactive oxygen species production and cardiomyocyte apoptosis caused by THP (P  less then  .01), which is consistent with the effect of RUT. Our results indicate that RUT treats THP-induced myocardial damage, which may be achieved by upregulating miR-22-5p, causing changes in its target gene Rap1a and the RAP1/ERK pathway.The world is currently transitioning from a fossil-fuel-driven energy economy to one that is supplied by more renewable and sustainable materials. Trees as the most abundant renewable bioresource have attracted significant attention for advanced materials and manufacturing in this epochal transition. Trees are composed with complex structures and components such as trunk (stem and bark), leaf, flower, seed, and root. Although many excellent reviews have been published regarding advanced applications of wood and wood-derived biopolymers in different fields, such as energy, electronics, biomedical, and water treatment, no reviews have revisited and systematically discussed functional materials and even devices derived from trees in a full scope yet. Therefore, a timely summary of the recent development of materials and structures derived from different parts of trees for sustainability is prsented here. A concise introduction to the different parts of the trees is given first, which is followed by the corresponding chemistry and preparation of functional materials using various biopolymers from trees. The most promising applications of biopolymer-based materials are discussed subsequently. A comprehensive review of the different parts of trees as sustainable functional materials and devices for critical applications is thus provided.

Radiomics in neuroimaging has gained momentum as a noninvasive prediction tool not only to differentiate between types of brain tumors, but also to create phenotypic signatures in neurological and neuropsychiatric disorders. However, there is currently little understating about the robustness and reproducibility of radiomic features in a baseline normative population.

To investigate the intra- and interscanner reproducibility, spatial robustness, and sensitivity of radiomics on fluid attenuation inversion recovery (FLAIR) images, which are widely used in neuro-oncology investigations.

Retrospective.

Three separate datasets of healthy controls 1) 87 subjects (age range 12-64 years), 2) intrascanner three timepoints, four subjects, and 3) interscanner, eight subjects at three different sites.

T

-weighted FLAIR at 1.5T and 3.0T.

Spatial variance across lobes, and their relation with age/gender, intra- and inter-scanner reproducibility (with and without site harmonization) of radiomics.

Analysis of variance (ANOVA), interclass correlation (ICC), coefficient of variation (CoV), Bland-Altman analysis.