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Participants articulate in their narratives their nuanced cultural understanding of good health as a complex, holistic practice, the achievement of which is obstructed by barriers such as immigration and insurance structures. Further, they enact their agency in resource impoverished circumstances to protect their mental health and physical well-being through daily strategies and acts of resistance.Black Americans make up 13% of the U.S. population, yet account for 54% of HIV deaths and 44% of new HIV diagnoses. Why do Black Americans die from HIV at such a disproportionate rate? In the current study, we asked whether the presence and behavior of in-group peers in public health settings may influence Black Americans' attention to HIV information, given the racialized nature of HIV-stigma in Black American communities. In a quasi-experimental field study conducted in a public health clinic (N = 260), we found that Black patients were less likely to pay attention to HIV-prevention information in the presence of other Black patients, unless those patients were also paying attention to the information. In contrast, Black patients' attention was unaffected by the presence of White patients. We end by discussing the implications of these findings for health communication theories and health practice geared toward reducing racial-health disparities in the United States.Young sexual minority women (SMW) report worse sexual health outcomes in comparison to their heterosexual peers. One potential reason for this disparity could be SMW's lack of access to accurate and appropriate sexual health information. Many sexual minority youth report school-based sexual health curricula to be less useful than do heterosexual youth. As such, SMW may be more likely to seek sexual health information online. However, not all online sexual health information is relevant to the health needs of young SMW, and resources targeting SMW have been found to be lower in quality. Understanding more about how young SMW navigate and evaluate online sexual health resources is necessary to better identify their pathways of access to information. The current qualitative study addresses this issue through analyzing data from a series of focus groups with young SMW on their experiences of evaluating online sexual health information. The primary findings indicate that the young SMW in the current sample employ an extensive filtering system to identify the quality of any particular resource, and the criteria for these systems differ depending upon whether participants were seeking personal narratives or evidence-based information. Implications for sexual health information communication and interactions with healthcare providers are addressed.Phytochemical investigation of Chromolaena laevigata led to the isolation of a new cadinene-sesquiterpene, chromolaevigone glucoside (1), along with nine known compounds daucosterol (2), stigmasterol glycoside (3), stigmasterol (4), β-sitosterol (5), pilloin (6), gonzalitosin I (7), quercetin-3-O-α-rhamnopyranoside (8), 7,7-dihydroxy-calamen-12-oic acid lactone (9) and trachelanthic acid (10). Others 11 known compounds were identified by UHPLC-HRMS/MS. These compounds are being described for the first time in this species, with the exception of cadinene 9. Furthermore, due to the limitation of pharmacological studies, antiproliferative, antiviral, and antimicrobial activities of C. laevigata were evaluated. The best results in the cytotoxicity, antimicrobial and antiproliferative tests, presenting GI50 values on ovarian tumour cells (OVCAR-03) of 1.9 μg mL-1 and kidney (786-0) of 2.5 μg mL-1 were observed for the hexanic fraction.[Formula see text].Bilirubin is a natural cytoprotective agent and physiologic doses have proven to be beneficial in various models of organ and cellular transplantation. Recently, we showed that bilirubin has protective effects in models of pancreatic islet transplantation, preventing cell death associated with islet stress and suppressing the release of damage-associated molecular patterns. Despite these promising therapeutic attributes, the natural bilirubin used in these research studies is animal-derived (porcine), making it unsuitable for clinical application. In the current study, we synthesized two bilirubin analogs that can be produced without the use of animal-derived products. Antioxidant activity for the analogs was measured using the ferric-reducing-ability-of-plasma (FRAP) and 2,2V-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) assays. Dose-dependent cytotoxicity and cytoprotective effects were then demonstrated in isolated rat islets. Compound 1 showed similar antioxidant activity to natural bilirubin. Mardepodect concentration Dose-dependent cytotoxicity was seen following treatment with Compound 1 and natural bilirubin at doses >40 μM, resulting in significantly increased cell death when compared to control islets (P less then 0.05) or islets treated with doses ≤20 μM (P less then 0.05). Following hypoxic challenge, islet cell death was reduced in islets treated with Compound 1 at 10 μM (17.27% ± 0.26%) compared to natural bilirubin at 10 μM (51.36% ± 0.71%; P less then 0.0001) or 20 μM (59.02% ± 0.83%; P less then 0.0001) and control islets (36.51% ± 0.44%; P less then 0.0001). Compound 1 was found to have promising antioxidant and cytoprotective effects, limiting islet cell death in a model of islet transplantation hypoxic stress. Compound 1 may serve as a synthetic drug lead for clinical islet transplantation and further evaluation of this molecule and its analogs is warranted.The use of allogeneic hematopoietic stem cell transplantation (HSCT) is recommended during the first complete remission of acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). However, only 30% of these cases have fully matched sibling donors (MSDs). Alternatively, matched unrelated donors (MUDs) and haploidentical (haplo) donors from first-degree relatives increase the access to transplantation, with some reported differences in outcomes. The current systematic review and meta-analysis was conducted with the aim of summarizing the results of those studies to compare the efficacy and toxicity of MSD-HSCT and MUD-HSCT versus haplo-HSCT for patients with AML or MDS. Articles published before September 15, 2018, were individually searched for in two databases (MEDLINE and EMBASE) by two investigators. The effect estimates and 95% confidence intervals (CIs) from each eligible study were combined using the Mantel-Haenszel method. A total of 14 studies met the eligibility criteria and were included in the meta-analysis.