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We show that the proposed MLP works very well for large patches wherein a reliable estimation of R and S can be made. However, its classification becomes inaccurate for small patches, where the proposed CNN provides accurate classifications.Many types of cancers are associated with changes in tissue mechanical properties. This has led to the development of elastography as a clinically viable method where tissue mechanical properties are mapped and visualized for cancer detection and staging. In quasi-static ultrasound elastography, a mechanical stimulation is applied to the tissue using ultrasound probe. Using ultrasound radiofrequency (RF) data acquired before and after the stimulation, the tissue displacement field can be estimated. Elasticity image reconstruction algorithms use this displacement data to generate images of the tissue elasticity properties. The accuracy of the generated elasticity images depends highly on the accuracy of the tissue displacement estimation. Tissue incompressibility can be used as a constraint to improve the estimation of axial and, more importantly, the lateral displacements in 2D ultrasound elastography. Especially in clinical applications, this requires accurate estimation of the out-of-plane strain. Here, we propose a method for providing an accurate estimate of the out-of-plane strain which is incorporated in the incompressibility equation to improve the axial and lateral displacements estimation before elastography image reconstruction. The method was validated using in silico and tissue mimicking phantom studies, leading to significant improvement in the estimated displacement.Cancer is known to induce significant structural changes to tissue. In most cancers, including breast cancer, such changes yield tissue stiffening. As such, imaging tissue stiffness can be used effectively for cancer diagnosis. One such imaging technique, ultrasound elastography, has emerged with the aim of providing a low-cost imaging modality for effective breast cancer diagnosis. In quasi-static breast ultrasound elastography, the breast is stimulated by ultrasound probe, leading to tissue deformation. The tissue displacement data can be estimated using a pair of acquired ultrasound radiofrequency (RF) data pertaining to pre- and post-deformation states. The data can then be used within a mathematical framework to construct an image of the tissue stiffness distribution. Ultrasound RF data is known to include significant noise which lead to corruption of estimated displacement fields, especially the lateral displacements. In this study, we propose a tissue mechanics-based method aiming at improving the quality of estimated displacement data. We applied the method to RF data acquired from a tissue-mimicking phantom. The results indicated that the method is effective in improving the quality of the displacement data.Ultrasound images are potentially invaluable for imaging internal organs and diseases. However, due to noise, they are still difficult to interpret. We apply and compare supervised machine learning approaches to train a model of lesions using features with unsupervised machine learning approaches to segment and detect tumours in breasts. Two synthetic and one real datasets are used in our experiments. The best system performance is achieved by Frost Filter with Quick Shift.Segmentation of carotid vessel wall is required in vessel wall volume (VWV) and local vessel-wall-plus-plaque thickness (VWT) quantification of the carotid artery. Manual segmentation of the vessel wall is time-consuming and prone to interobserver variability. In this paper, we proposed a convolutional neural network (CNN) to segment the common carotid artery (CCA) from 3D carotid ultrasound images. The proposed CNN involves three U-Nets that segmented the 3D ultrasound (3DUS) images in the axial, lateral and frontal orientations. The segmentation maps generated by three U-Nets were consolidated by a novel segmentation average network (SAN) we proposed in this paper. The experimental results show that the proposed CNN improved the segmentation accuracies. Compared to only using U-Net alone, the proposed CNN improved the Dice similarity coefficient (DSC) for vessel wall segmentation from 64.8% to 67.5%, the sensitivity from 63.8% to 70.5%, and the area under receiver operator characteristic curve (AUC) from 0.89 to 0.94.Scoliosis is a 3D spinal deformation where the spine takes a lateral curvature, which generates an angle in a coronal plane. For periodic detection of scoliosis, safe and economic imaging modality is needed as continuous exposure to radiative imaging may cause cancer. 3D ultrasound imaging is a cost-effective and radiation-free imaging modality which gives volume projection image. Ginkgolic order Identification of mid-spine line using manual, semi-automatic and automatic methods have been published. Still, there are some difficulties like variations in human measurement, slow processing of data associated with them. In this paper, we propose an unsupervised ground truth generation and automatic spine curvature segmentation using U- Net. This approach of the application of Convolutional Neural Network on ultrasound spine image, to perform automatic detection of scoliosis, is a novel one.In ultrasound imaging, there is a trade-off between imaging depth and axial resolution because of physical limitations. Increasing the center frequency of the transmitted ultrasound wave improves the axial resolution of resulting image. However, High Frequency (HF) ultrasound has a shallower depth of penetration. Herein, we propose a novel method based on Generative Adversarial Network (GAN) for achieving a high axial resolution without a reduction in imaging depth. Results on simulated phantoms show that a mapping function between Low Frequency (LF) and HF ultrasound images can be constructed.Normalized cross-correlation (NCC) function used in ultrasound strain imaging can get corrupted due to signal decorrelation inducing large displacement errors. Bayesian regularization has been applied in an iterative manner to regularize the NCC function and to reduce estimation variance and peak-hopping errors. However, incorrect choice of the number of iterations can lead to over-regularization errors. In this paper, we propose the use of log compression of regularized NCC function to improve subsample estimation. Performance of parabolic interpolation before and after log compression of the regularized NCC function were compared in numerical simulations of uniform and inclusion phantoms. Significant improvement was achieved with the proposed scheme for lateral estimation results. For example, lateral signal-to-noise ratio (SNR) was 10 dB higher after log compression at 3% strain in a uniform phantom. Lateral contrast-to-noise ratio (CNR) was 1.81 dB higher with proposed method at 3% strain in inclusion phantom.