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The univariate bootstrap is a relatively recently developed version of the bootstrap (Lee and Rodgers in Psychol Methods 3(1) 91, 1998). DeFries-Fulker (DF) analysis is a regression model used to estimate parameters in behavioral genetic models (DeFries and Fulker in Behav Genet 15(5) 467-473, 1985). It is appealing for its simplicity; however, it violates certain regression assumptions such as homogeneity of variance and independence of errors that make calculation of standard errors and confidence intervals problematic. Methods have been developed to account for these issues (Kohler and Rodgers in Behav Genet 31(2) 179-191, 2001), however the univariate bootstrap represents a unique means of doing so that is presaged by suggestions from previous DF research (e.g., Cherny et al. in Behav Genet 22(2) 153-162, 1992). In the present study we use simulations to examine the performance of the univariate bootstrap in the context of DF analysis. We compare a number of possible bootstrap schemes as well as more traditional confidence interval methods. We follow up with an empirical demonstration, applying results of the simulation to models estimated to investigate changes in body mass index in adults from the National Longitudinal Survey of Youth 1979 data.PURPOSE OF REVIEW In this study, we present the evidence-based management for patients hospitalized for ulcerative colitis (UC) with a special focus on the synergic approach of the two key actors of the inflammatory bowel disease multidisciplinary team (IBD-MDT) gastroenterologist and surgeon. RECENT FINDINGS Focused treatment by a specialized IBD-MDT and early involvement of the colorectal surgeon in the management of hospitalized UC patients is advocated. The colectomy rate has not changed over the years. Moreover, delayed surgery after admission is burden by increase complication and mortality rates. Thus, it is pivotal to identify the patients who are likely to undergo surgery, by mean of predictors of outcome, and not to prolong ineffective medical treatment. The perfect timing based on clinical close monitoring is crucial. selleck products Up to 25% of patients with ulcerative colitis (UC) may require hospitalization. The aim of admission is to evaluate severity of the disease, exclude infections and establish proper treatment while monitoring the response. link2 During admission, the patient has to be closely observed for the possible development of toxic megacolon or perforation, which should prompt emergency colectomy. Up to 30% of UC patients will fail to respond to initial intravenous corticosteroid. Non-responder or partial responder to medical therapy should be evaluated for timely surgery or could be considered for rescue medical therapy.Despite the success of cross-sectional imaging in evaluating hepatopancreatobiliary system malignancies, several non-malignant disease processes may closely mimic malignancy. Differentiating these benign diseases from malignancy may be difficult, or even impossible, even in the hands of experienced imagers. In this manuscript, we present benign mimics involving the hepatopancreatobiliary system and try to increase awareness of these potential pitfalls.BACKGROUND Wild-abortive cytoplasmic male sterility (CMS-WA) and Honglian CMS (CMS-HL) are the two main CMS types utilized in production of three-line hybrid rice in xian/indica (XI) rice. Dissection of the genetic basis of fertility restoration of CMS-WA and CMS-HL in the core germplasm population would provide valuable gene and material resources for development of three-line hybrid combinations. RESULTS In this study, two F1 populations with CMS-WA and CMS-HL background respectively were developed using 337 XI and aus accessions being paternal parents. Genome-wide association studies on three fertility-related traits of the two populations for two consecutive years revealed that both fertility restoration of CMS-WA and CMS-HL were controlled by a major locus and several minor loci respectively. The major locus for fertility restoration of CMS-WA was co-located with Rf4, and that for fertility restoration of CMS-HL was co-located with Rf5, which are cloned major restorer of fertility (Rf) genes. Furthermore, haplotype analysis of Rf4, Rf5 and Rf6, the three cloned major Rf genes, were conducted using the 337 paternal accessions. Four main haplotypes were identified for Rf4, and displayed different subgroup preferences. Two main haplotypes were identified for Rf5, and the functional type was carried by the majority of paternal accessions. In addition, eight haplotypes were identified for Rf6. CONCLUSIONS Haplotype analysis of three Rf genes, Rf4, Rf5 and Rf6, could provide valuable sequence variations that can be utilized in marker-aided selection of corresponding genes in rice breeding. Meanwhile, fertility evaluation of 337 accessions under the background of CMS could provide material resources for development of maintainer lines and restorers.Integration of low-cost air quality sensors with the internet of things (IoT) has become a feasible approach towards the development of smart cities. Several studies have assessed the performance of low-cost air quality sensors by comparing their measurements with reference instruments. We examined the performance of a low-cost IoT particulate matter (PM10 and PM2.5) sensor in the urban environment of Santiago, Chile. The prototype was assembled from a PM10-PM2.5 sensor (SDS011), a temperature and relative humidity sensor (BME280) and an IoT board (ESP8266/Node MCU). Field tests were conducted at three regulatory monitoring stations during the 2018 austral winter and spring seasons. The sensors at each site were operated in parallel with continuous reference air quality monitors (BAM 1020 and TEOM 1400) and a filter-based sampler (Partisol 2000i). Variability between sensor units (n = 7) and the correlation between the sensor and reference instruments were examined. Moderate inter-unit variability was observed between sensors for PM2.5 (normalized root-mean-square error 9-24%) and PM10 (10-37%). The correlations between the 1-h average concentrations reported by the sensors and continuous monitors were higher for PM2.5 (R2 0.47-0.86) than PM10 (0.24-0.56). The correlations (R2) between the 24-h PM2.5 averages from the sensors and reference instruments were 0.63-0.87 for continuous monitoring and 0.69-0.93 for filter-based samplers. Correlation analysis revealed that sensors tended to overestimate PM concentrations in high relative humidity (RH > 75%) and underestimate when RH was below 50%. Overall, the prototype evaluated exhibited adequate performance and may be potentially suitable for monitoring daily PM2.5 averages after correcting for RH.The microalga Dunaliella salina has been broadly studied for different purposes such as beta-carotene production, toxicity assessment and salinity tolerance, yet research on the habitat suitability of this alga has rarely been reported. The present research aims to apply a suitable monitoring and modelling methods (two critical steps in ecological researches) to predict the abundance of D. salina. The abundance of D. salina was predicted by decision tree model (J48 algorithm) in 10 different monitoring sites during 1-year study period (2016-2017) in the Meighan wetland, one of the valuable hypersaline wetlands in Iran. The abundance of alga (as output of model) together with various water quality and physical-habitat wetland characteristics (as inputs of model) were monthly and repeatedly monitored in two different depths (one from the surface layer and another one from the depth of maximum 50 cm) which in total resulted in 240 instances (120 instances for each depth). Based on trial and error, a sevenfold crs anthropogenic activities.PURPOSE Utilization of electronic patient-reported outcomes (ePROs) in the clinic can improve quality of life and prolong survival in cancer care. However, there remain unanswered questions regarding trends in missing data and the potential effect on real-time patient care. METHODS This study utilized a prospectively collected dataset of ePROs from oncology clinics that administered the Patient Care Monitor 2.0 (PCM), a validated symptoms survey assessing 78 items for men, and 86 for women. We tabulated the frequency of missing items, by item and domain (emotional, functional and physical symptom-related), and examined these by age, gender, education, race and marital status. RESULTS Within 20,986 encounters, there were responses to at least 1 PCM item from 6933 unique patients. The highest frequency of missing answers occurred for "attend a paid job" (10.7%), "reduced sexual enjoyment" (3.8%), and "run" (3.7%). By domain, 12.3% of functional, 8.4% of physical symptom-related, and 1.6% of emotional constructs contained at least one missing item. For functional and physical symptom-related items, missingness was most common in patients >60 years old. CONCLUSION The frequency of missingness was highest for functional items, like attending a paid job, suggesting that some respondents (e.g., retirees without a paid job) skipped questions that were less applicable to them. More universal issues for cancer patients, such as emotional well-being, had much lower frequencies of missingness. This suggests differential item completion that warrants further study to understand the inherent drivers. Identifying causes of missingness could improve the clinical utility of ePROs and highlight opportunities to personalize care.PURPOSE The aim of the study was to assess health-related quality of life (HRQoL) and contributing factors among parents of children with solid tumors in Serbia. METHODS The cross-sectional study included 51 parents of children treated for different solid tumors at the Institute of Oncology and Radiology of Serbia. Parents filled out validated Serbian version of SF-36 questionnaire. Hierarchical multiple regression analysis was conducted to identify predictors of total score of SF-36. link3 RESULTS Almost all parents (94.1%) were mothers and average age was 38.6 ± 6.7 years. Majority of children had brain tumors (43.1%), followed by bone tumors (37.3%). The hierarchical regression analysis showed that socio-demographic characteristics explained 26% of the variance (p > 0.05) of the total score of SF-36. Addition of quality of life of children assessed by parents in the second model caused an increase of 21% in the variance explained (p  less then  0.05). After adding the Beck Depression Inventory score in the third block, an additional 18% of the variance in total score was explained (p  less then  0.05). CONCLUSIONS This study showed that HRQoL measured by SF-36 in parents of children with cancer is strongly influenced by depression and quality of life of children assessed by parents.PURPOSE In Australia, the number of cancer cases has doubled since 1991 and is the second most common cause of death as reported by Chen, H., et al. (Supportive Care in Cancer, 2018. 27 p. 451-460). Chemotherapy, a common treatment, is known to cause distressing symptoms that often lead to a person presenting to an emergency department (ED). The aim of this study was to investigate whether a nurse practitioner (NP)-led model of care could improve cancer service integration and reduce hospital presentations. METHODS This was an evaluation study for a new model of care that included (i) telephone helpline; (ii) urgent assessment clinic; and (iii) rapid day treatment consultation service. RESULTS The utilisation rate was 337 telephone calls involving 157 patients in the 7-month pilot. The most common reason for calling the helpline was for symptom management (n = 173, 51%), followed by education regarding treatment (n = 61, 18%). As a result, 49% (n = 165) of callers were given advice, information, or education; 22% (n = 74) were referred on to other healthcare providers; and 11% (38) were admitted to hospital.