Langemathis4362

88/18.3/2.2 for the central gland, 0.75/22.8/1.9 for the peripheral zone, and 0.45/36.7/17.4 for PCa. Compared with Reader 2, the DSC/HD/ASD were 0.88/17.5/2.6 for the central gland, 0.73/33.2/1.9 for the peripheral zone, and 0.4/39.5/19.1 for PCa. Interrater agreement measured in DSC/HD/ASD was 0.87/11.1/1.0 for the central gland, 0.75/15.8/0.74 for the peripheral zone, and 0.6/18.8/5.5 for PCa. Segmentation performances on the Medical Segmentation Decathlon and PROSTATEx were 0.82/22.5/3.4; 0.86/18.6/2.5 for the central gland, and 0.64/29.2/4.7; 0.71/26.3/2.2 for the peripheral zone.

We provide an openly accessible, expert-annotated 3T dataset of prostate MRI and a reproducible benchmark to foster the development of prostate segmentation algorithms.

We provide an openly accessible, expert-annotated 3T dataset of prostate MRI and a reproducible benchmark to foster the development of prostate segmentation algorithms.Predicting temporal changes in PAH concentrations in urban soils and their corresponding health risk is essential for developing appropriate management measures to prevent those risks. Concentrations of PAHs in soils of residential areas with different building ages in three metropolitan cities were determined to estimate the accumulation rates of PAHs in soil. The mean concentrations of total PAHs (∑PAHs) were 1297 ng/g in Shanghai, 865 ng/g in Beijing, and 228 ng/g in Shenzhen. The primary sources of the PAHs were traffic and coal combustion for industrial activity and space heating. The high PAH concentrations in Shanghai were attributed to the relatively high average building age of the sampled residential areas and the low annual temperature in the city. The overall annual accumulation rates of PAHs in the soils were estimated from linear regressions between the PAH concentrations and building age of the residential areas. The annual accumulation rate of PAHs in the soils was 64.7 ng/g in Beijing, 24.2 ng/g in Shanghai, and 3.3 ng/g in Shenzhen. The higher rate in Beijing was due to the higher intensity of PAH emissions and the lower temperature. The regression estimations suggest that health risks posed by PAHs in residential soils of the metropolitan cities increase considerably with time.The application of additives to regulate the microbial functional composition during composting has attracted much research attention. However, little is known about the succession and role of the fungal community in the laboratory-scale composting of vegetable waste supplemented with pig manure and microbial agents. The purpose of this study was to identify effective additives for improving vegetable waste composting performance and product quality, and to analyze the microbial community succession during composting. The results showed that the combined addition of pig manure and microbial agents (T2 treatment) accelerated the pile temperature increase, enhanced total organic carbon degradation (23.36%), and promoted the maturation of the compost. Furthermore, the T2 treatment increased the activities of most enzymes, reshaped the microbial community, and reduced the relative abundance of potential animal (1.60%) and plant (0.095%) pathogens. The relative abundance of Firmicutes (71.23%) increased with the combined addition of pig manure and microbial agents in the thermophilic stage. In the middle and late stages, Saccharomonospora, Aspergillus, and Thermomyces, which were related to C/N and total phosphorus, were enriched in the T2 treatment. Network analysis demonstrated that the complexity and stability of the fungal network were more evidently increased in the T2 treatment, and Saccharomonospora, Aspergillus, and Microascus were identified as keystone taxa. The keystone taxa associated with extracellular enzymes contributed significantly to compost maturation. These results provide a reference for the application of additives to improve compost safety in pilot-scale composting.Face masks play a crucial protective role in preventing the spread of coronavirus disease during the COVID-19 pandemic, but the improper disposal of used face masks also causes an emerging environmental problem, such as microplastic contamination. Here, the aim was to evaluate the improper disposal of used face masks and, subsequently, the potential contribution to microplastic contamination in urban rivers. First, we investigated the occurrence of discarded face masks in Qing River through continuously one-month collection on-site, and the disposable masks with a density of (8.28 ± 4.21) × 10-5 items/m2 with varying degrees of wear and tear were found. Next, the microfibers shedding from two popular types of new disposable masks were tested. The results showed that 50.33 ± 18.50 items/mask of microfibers, ranging from 301 μm to 467 μm in size, were released from the disposal face mask after immersion in ultrapure water for 24-h. It was significantly higher than the KN95 respirator of 31.33 ± 0.57 items/mask, ranging from 273 μm to 441 μm. Besides C and O elements only found in new face masks, some potentially toxic elements were also detected on the surface of discarded face masks, indicating that various environmental contaminations are easy to adsorb on the surface of discarded face masks. The results implied that these discarded face masks in an aquatic environment are emerging sources of microfibers and could act as transport vectors for contaminants, which would aggravate the present microplastic contamination. In conclusion, these findings were expected to raise public awareness of the proper disposal of used face masks to prevent microplastic contamination and the spread of COVID-19 in the environment.This study presents the effect of electro-oxidation and Fenton pre-treatment on anaerobic co-digestion (AnCoD) of fruit-juice industrial waste (FJW) and municipal sewage sludge (MSS). Biogas production increased from 767 mL to 857 mL and 918 mL after EO and Fenton pretreatment, respectively. The methane amount increased by 28% and 39% for EO and Fenton processes. The removal efficiencies of soluble COD, carbohydrate, and protein for the conditions with the highest biogas production as a result of the pretreatment process were 48%, 65%, 61% for the Fenton pre-treatment, and 37%, 52%, and 39% for the EO pre-treatment, respectively. Cumulative biogas production efficiency for all pre-treated mixtures was estimated with kinetic models. In addition, an evaluation has been made regarding cost, economic gain, and energy consumption of the pre-treatment processes.Osteoarthritis (OA) is the commonest joint condition globally, affecting 18 % of women over the age of 60 years, although the prevalence varies according to the definition used. Although it may develop in any joint, it most commonly affects joints of the knee, hip, hand, spine and foot. Because OA often emerges in women in midlife, there has been longstanding interest in the association between hormonal status and the development and progression of OA. Researchers have variably suggested that estrogen exposure may be a risk factor for OA development, or that, conversely, it may be used as a therapy to treat OA. This review considers the historical development of this question, first described in the literature in 1805, and highlights the need for future research in this area.Ageing is defined as the 'increasing frailty of an organism with time that reduces the ability of that organism to deal with stress'. It has been suggested that epigenetics may underlie the observation that some individuals appear to age faster than others. Epigenetics is the study of changes which occur in an organism due to changes in expression of the genetic code rather than changes to the genetic code itself; that is, epigenetic mechanisms impact upon the function of DNA without changing the DNA sequence. It is important to recognise that epigenetic changes, in contrast to genetic changes, can vary according to different cell types and therefore can demonstrate significant tissue-specificity. NDI-091143 mw There are different types of epigenetic mechanisms histone modification, non-coding RNAs and DNA methylation. Epigenetic clocks have been developed using statistical techniques to identify the optimal combination of CpG sites (from methylation arrays) to correlate with chronological age. This review considers how epigenetic factors may affect rates of ageing of muscle and bone and provides an overview of current understanding in this area. We discuss studies using first-generation epigenetic clocks, as well as the second-generation iterations, which appear to show stronger associations with the ageing muscle phenotype. We also review epigenome-wide association studies that have been performed in various tissues examining relationships with osteoporosis and fracture. It is hoped that an understanding of this area will lead to interventions that might prevent or reduce rates of musculoskeletal ageing in later life.

The SED-S is a standardized diagnostic instrument for assessing emotional development (ED) in people with a disorder of intellectual development. The SED-S defines five ED stages covering emotional reference ages up to 12 years in eight domains (5 items per domain). Stage 6 will extend the scale for early adolescent reference ages.

The aim of this study is to define the SED-S items for stage 6 ('Social Individuation').

Experts in developmental psychology phrased 56 items (7 items/domain) describing typical behaviors for emotional reference ages 13th-18th year (145th-216th month) in English, German and Dutch. Twenty-eight independent experts assessed the items' content validity and observability on a Likert scale (0= good to 3= unacceptable). Two items/domain with the lowest ratings were excluded to finally select 5 items/domain for SED-S stage 6.

The ratings were good with results ranging from 0.06 to 0.78 for validity and 0.06-1.78for observability. After exclusion of the 2 lowest ranking items/domaichometric properties. WHAT THIS PAPER ADDS? The current version of the SED-S covers emotional reference ages up to 12 years (144 months). Extending the SED-S for emotional reference ages up to 18 years (145th-216th months of life) in Dutch, German and English allows better differentiation in the higher ED range and expands the applicability of the scale. Specifically, it makes it possible to apply the SED-S in people with borderline intellectual functioning. Accounting for the level of ED may provide valuable information about the behaviors and needs of individuals with higher reference ages and may support targeted treatment options in a population highly vulnerable to behavioral or mental disorders.A challenging but critical question is that new foot-and-mouth disease (FMD) vaccines should be to induce B cell memory to provide antibodies for long-term protection. The maintenance of B cell memory is dependent on long-lived plasma cells (LLPCs) and memory B cells. We developed a chimeric FMDV virus-like particles (FMDV-VLPs), fusing VP1-VP4 into HBcAg. In our study, we investigated if or how long B cell memory was induced by FMDV-VLPs in mice. The data showed that FMDV-VLPs can induce memory humoral responses with a high level of total IgG1, IgG2a, IgA, and FMDV-specific IgG antibodies in serum. The persistence of antibody levels in serum could depend on LLPCs. The proportion of LLPCs in CD19+ cells in bone marrow exhibited a dynamic trend with two peaks at 28 days post-immunization (dpi) and 72 dpi, respectively. Additionally, the proportion of memory B cells in CD19+ cells in the spleen increased significantly both at 7 days post primary immunization and at 7 days post -boost immunization. Of note, LLPCs together with memory B cells contribute to the production of FMDV-specific IgG and IgG1.