Langballehonore9949

Bacterial cellulose(BC) is a kind of extracellular polymer synthesized by bacteria and it has very wide applications in many fields. However, the application of BC in a large commercial scale can still not be fulfilled due to the low yield and demanding for BC membranes with very different properties. To this end, a new BC-producer Komagataeibacter rhaeticus TJPU03 was isolated from rotten orange peel, which produced 8.28 ± 0.27 g/L(dry weight) in standard HS medium at the 10th day. The membrane is easier to be purified by one-step alkaline treatment and the produced BC(K-BC) membranes possess homogeneous, looser and more porous three-dimensional network composed by thinner cellulose fibrils. However, the wet K-BC possesses stronger mechanical properties and exhibits lower toxicity and higher cytocompatibility to mammalian cell. Owing to the more porous and homogeneous network, K-BC possesses high loading capacity of cell and protein drugs. Also, it exhibits sustained-controlled release ability for proteinaceous drug. The high yield of this strain and the special characteristics of K-BC predict this strain to be a very promising BC-producer and broad applications of K-BC in the fields of wound healing, scaffolds of tissue engineering, tissue repair and regeneration.Background While evidence suggests that hydroxychloroquine (HCQ) may decrease the viral load in patients with a COVID-19 infection, a number of case reports indicate adverse dermatologic effects of this potential treatment. Objective To conduct a systematic review of previously reported cases of psoriasis onset, exacerbation, or relapse after HCQ treatment. Methods A comprehensive EMBASE and MEDLINE search of original studies examining adverse effects of HCQ treatment related to psoriasis was conducted. Participant demographics, and details of HCQ administration and psoriasis diagnosis were extracted from 15 articles representing 18 patients. Results Females accounted for a significantly larger number of psoriatic cases compared to males and unreported sex (n=14, 77.8% vs. n=2, 11.1% vs n=2, 11.1% respectively). Additionally, 50% (n=9) of the cases did not have a history of psoriasis prior to taking HCQ. Of the 18 patients, 50.0% (n=9) experienced de novo psoriasis, 27.8% (n=5) experienced exacerbation of psoriatic symptoms and 22.2% (n=4) had a relapse of psoriasis after HCQ administration. Conclusions HCQ treatment may result in induction, exacerbation, or relapse of psoriasis. Monitoring for adverse effects of HCQ treatment is necessary, and clinical trials are essential in characterizing the safety profile of HCQ use in patients with a COVID-19 infection.Background Intralesional injection of sterile medications remains a mainstay in dermatology, enabling a tailored, low-cost, in-office therapy. Following the 2012 United States outbreak of fungal meningitis from contaminated intrathecally administered corticosteroids, there has been increased regulation of in-office compounding, regardless of administration route. Studies demonstrating the safety data of in-office corticosteroid compounding for intradermal or subcutaneous use are lacking. Objective To assess the incidence of infection caused by compounded in-office intralesional triamcinolone. Methods A retrospective chart review identified subjects that received in-office intralesional corticosteroid injections in 2016. Medical documentation within 30 days of injection was reviewed for suspected infection. see more Results Charts of 4370 intralesional triamcinolone injections were assessed, 2780/4370 (64%) being compounded triamcinolone with bacteriostatic saline. Eleven suspected localized infections (0.25%) were identified, with 4/11 in the compounding cohort. Of these, 7/11 occurred after injection of an "inflamed cyst." No hospitalizations or deaths occurred. No temporal/locational relationships were identified. Limitations This study was limited to two academic institutions. A 30-day post injection time frame of was used. Conclusion In-office compounding for intralesional dermal and subcutaneous administration is safe when sterile products are used by medical practitioners. There is no increased risk of compounded triamcinolone relative to non-compounded triamcinolone.Background Melanoma in situ (MMIS) and dysplastic nevi with severe atypia (DNSA) present overlapping histopathological features. Reflectance Confocal Microscopy (RCM) findings can be integrated with the dermatopathology report to improve differentiation between melanoma and DNSA. Objective To compare prevalence of RCM findings between MMIS and DNSA METHODS This retrospective observational study compared RCM findings in dermatopathologically-diagnosed DNSA and MMIS, collected between 2007-2017 at a private pigmented-lesion clinic. Concordant pathological diagnosis was defined as unanmimous agreement between three dermatopathologists that independently reviewed all cases; all other cases were classifed as discordant. Results The study included 112 lesions, 62 concordant-MMIS, 28 concordant-DNSA, and 22 discordant lesions. Comparing RCM findings in concordant cases, MMIS showed more frequently than DNSA the presence of epidermal atypical melanocytes as round cells (19/62 vs. 0/28, p less then 0.001) and dendritic cells (50/62 vs. 6/28, p less then 0.001), as well as a diffuse distribution of epidermal atypical melanocytes (50/54 vs. 3/6, p=0.002). In contrast, DNSA showed more frequently than MMIS the presence of dense melanocytic nests (15/28 vs. 14/62, p=0.003). Limitations The study was based on a limited number of lesions originating from a single clinic. Conclusions RCM findings may help differentiate a subset of DNSA from MMIS.Purpose Participation in physical activity supports greater cardiorespiratory fitness (CRF), a correlate of cognitive control. However, the relationship between muscular fitness (MF) and cognitive control is less clear. The present study investigated the differential relationship of CRF and MF with cognitive control in older adolescents. Methods This cross-sectional study involved students (15-17 years old, n = 541, 43% female) from 20 secondary schools who completed tests of inhibition (modified flanker task), working memory (n-back task), CRF (Progressive Aerobic Cardiovascular Endurance Run), and MF (standing long jump and push-up test). Multilevel analyses tested the association between CRF or MF and cognitive outcomes while accounting for the influence of the other fitness variable and relevant demographic factors. Results CRF predicted response accuracy during incongruent flanker trials, the condition requiring greater inhibition. For the working memory task, CRF predicted greater target accuracy and greater d' scores on the 1-back task, requiring lesser amounts of working memory.