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Background  This study aims to evaluate association between suicidal ideation and pesticide exposure in rural communities of Wardha district of Central rural India compared with villagers who are not exposed to it. Method  It was a cross-sectional study done in rural community of Wardha district in Central India. About 100 farmers who were exposed to pesticides and 100 controls who were not exposed to pesticides were included. A Semistructured proforma to record sociodemographic variables and Indian version of the Self Reporting Questionnaire-20 was used. Results  Of these 200 subjects, data were available for 85 farmers in study group and 74 in control group. In the farmers group, 31% of farmers had suicidal ideas, while 8% of controls felt like ending their life. Conclusion  Measures must be taken to store pesticides at a safer place thus reducing long-term exposure. Organic farming is a better choice to avoid suicidal ideas.Objective  In contemporary neurosurgical practice, keyhole endoscopic approach has established its role in various neurosurgical pathologies. Intracranial epidermoid is an ideal pathology for endoscopic keyhole approach as epidermoid is well encapsulated, extra-axial, avascular, and easily suckable. The objective of this study is to share our experience of endoscopic keyhole approach for intracranial epidermoids at various locations as a new minimally invasive neurosurgical approach to deal with these lesions. Materials and Methods  We conducted a retrospective study on 26 patients who underwent keyhole pure endoscopic excision of intracranial epidermoid between July 2015 and December 2019. Patient's demographics, clinical features, radiological imaging, and postoperative complications were noted. Follow-up outcome of preoperative symptoms and postoperative complications were also analyzed. Results  The mean age of the study population was 30.5 years with a mean follow-up of 30 months. The common presenting features were headache, hearing loss, and trigeminal neuralgic pain. Gross total resection was achieved in 73.1% cases, while near total resection and subtotal resection were achieved in 19.2 and 7.7% cases, respectively. In the follow-up, maximal improvement was seen in trigeminal neuralgic pain (83%) and headache (66.7%). Major postoperative complications were facial nerve paresis, lower cranial nerve paresis, and transient facial hypoesthesia, most of which improved over time. None of the patients required resurgery till date. Statistical Analysis  Patients' data were analyzed using SPSS software version 23 (Statistical Package for Social Sciences, IBM, Chicago, United States). Conclusion  This study demonstrates that with careful patient selection, endoscopic keyhole excision of epidermoid is a good alternative to conventional microsurgical excision with comparable surgical and functional outcomes.Participant recruitment for pediatric palliative intervention studies is a chronic challenge for researchers. Digital recruitment strategies, or digital technology-assisted recruitment methods used to remotely reach and enroll research subjects, can help address these recruitment challenges for pediatric palliative care clinical trials. This study (a) describes Facebook recruitment procedures targeting children with cancer and their parents for a pediatric palliative intervention randomized clinical trial, (b) reports recruitment results, and (c) discusses successful strategies to recruit pediatric populations via Facebook advertisements. Researchers used Facebook advertisements to recruit children with advanced cancer (aged 7 to 17 years) for a web-based legacy intervention. Between years 2015 and 2018, our research team enrolled 150 child-parent dyads (N= 300) to participate in the web-based legacy program. Results suggest that Facebook advertisements can be a successful tool to access and recruit pediatric populations with life-threatening conditions. Further research is needed to determine how innovative social-media recruitment strategies could be used in other populations of patients with serious illnesses and their caregivers to further advance the science in palliative care.Culturally congruent parenting programs delivered during early childhood have the potential to support diverse families. Legacy for Children™ (Legacy) is a group-based prevention program designed to promote child development by reinforcing sensitive, responsive mother-child relationships, building maternal self-efficacy, and fostering peer networks of support among mothers living in poverty (Perou et al., 2012). The Legacy program was translated and culturally adapted for Spanish-speaking Latina mothers and their infants (hereafter referred to as Latina mothers) with a feasibility trial conducted to determine the cultural congruency of the adaptation. Feasibility results were positive with no previous studies validating the adapted Legacy Spanish language program (Legacy Spanish). The current manuscript focuses on understanding factors of engagement of the culturally adapted model. Specifically, we examined the factors that were perceived to have enhanced or hindered both initial and sustained engagement in tilar engagement strategies could enhance the success of early childhood parenting programs and linkages with early educational programming.Little is known about the effects of social media initiation on digital behaviors from middle childhood to early adolescence, a critical developmental period marked by peer influence and inaugural access to mobile devices. Participants from middle schools in the Northeast U.S. (N=773; 11-15 years, Mean = 12.6) completed a cross-sectional survey about social media initiation, digital behaviors, and parental restrictions on digital use. Descriptive results demonstrated that overall early adolescents more frequently engaged in positive digital behaviors compared to negative ones. Results from structural equation models showed that initiating social media platforms, namely Instagram or Snapchat, in later childhood (10 years or younger) was significantly associated with problematic digital behavior outcomes compared to either tween (11-12) and/or teen (13+) initiation, including having online friends or joining social media sites parents would disapprove of, more problematic digital technology behaviors, more unsympathetic online behaviors, and greater likelihood of online harassment and sexual harassment victimization. Additionally, there is evidence to show that childhood initiators demonstrated a greater tendency to engage in supportive or civically-engaged online community behaviors compared to older initiator counterparts. Parental restriction of mobile phone use and a less frequent checking of social media ameliorated some of the negative effects.The Automatic Quasi-clique Merger algorithm is a new algorithm adapted from early work published under the name QCM (introduced by Ou and Zhang in 2007). The AQCM algorithm performs hierarchical clustering in any data set for which there is an associated similarity measure quantifying the similarity of any data i and data j. Importantly, the method exhibits two valuable performance properties 1) the ability to automatically return either a larger or smaller number of clusters depending on the inherent properties of the data rather than on a parameter. 2) the ability to return a very large number of relatively small clusters automatically when such clusters are reasonably well defined in a data set. Cyclopamine cell line In this work we present the general idea of a quasi-clique agglomerative approach, provide the full details of the mathematical steps of the AQCM algorithm, and explain some of the motivation behind the new methodology. The main achievement of the new methodology is that the agglomerative process now unfolds adaptively according to the inherent structure unique to a given data set, and this happens without the time-costly parameter adjustment that drove the previous QCM algorithm. For this reason we call the new algorithm automatic. We provide a demonstration of the algorithm's performance at the task of community detection in a social media network of 22,900 nodes.Families with young children with and without developmental disabilities often create a musically rich home environment. Parent-child music engagement, like singing play songs, is associated with positive outcomes for children, parents, and their relationship. However, little is known about if the home music environment differs across diagnostic groups and if parent-child music engagement relates to parent-child affective attachment across families of diagnostically diverse children. Using an online questionnaire, the current study examined the home music environment of 340 families with young children with typical and atypical development. A variety of musical activities were common in all diagnostic groups. Diagnostic groups differed in active musical engagement, potentially relating to the differing phenotypes of various developmental disabilities. Parent-child music engagement was associated with parent-child affective attachment, even when controlling for relevant variables. Promoting musical engagement at home and through parent-child therapy may be an accessible way to support parent-child relationships.Decades of research finds associations between personality traits and health. In recent years, it has become clear that the activities of the immune system play a key role in linking these variables. In the current work, we add to this research by exploring the relationship between Big Five personality traits and (Study 1) polymorphisms known to impact cytokine release and (Study 2) immunological parameters measured in vivo (differential white blood cell counts, plasma proinflammatory cytokine levels) and in vitro (proinflammatory cytokine release by peripheral blood mononuclear cells, Staphylococcus aureus growth in plasma). Results provide insights into potential mechanistic drivers of the link between personality and immune function and the possibility that, in some cases, relationships between personality and immune function may be sex differentiated.Several socio-cognitive theories of personality describe habit development as an integral process of personality development. Yet, no empirical research has rigorously examined linkages between personality traits and habits. In the present study, participants (N=459) reported perceived automaticity, intrinsic rewards, and extrinsic rewards for several of 25 total behaviors; they also self-reported two important traits conscientiousness and neuroticism. Conditional multilevel mediation analyses were used to assess the effect of each conscientiousness and neuroticism on automaticity through intrinsic and extrinsic rewards for each behavior. Across behaviors, conscientiousness was negatively associated with behavioral automaticity, and neuroticism positively predicted it. Specifically, conscientiousness appeared to protect against automaticity for health risk behaviors but did not promote automaticity for behaviors performed frequently by those high in conscientiousness; conversely, neuroticism positively predicted automaticity even for behaviors not performed more frequently by those high on the trait. Perceived intrinsic and extrinsic rewards mediated the link between traits and automaticity for some behaviors (e.g., sugary drink consumption), but these effects were not consistent across all behaviors. These findings offer some of the first empirical insights into the links between personality and habits.

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