Kromannzamora0799

95]. For all hrHPV combinations, the addition of HPV 16 was associated with a higher risk of CIN2-3. CONCLUSIONS An increase in number of hrHPV types is associated with lower CIN2-3 risk. Further cohort studies with larger samples are needed to clarify this relationship. The available evidence suggests that HPV 16 genotype plays an important role in patients with high-grade cervical lesions and has a negative impact on the cervix in concurrent multiple HPV infections.The article "FBW7 inhibits nucleus pulposus cells proliferation by downregulation of cyclin E in the intervertebral disc degeneration, by J.-W. Xu, J. Wang, K. Yang, S. Guo, C.-S. Feng, H.-Y. Chen, H.-P. Li, published in Eur Rev Med Pharmacol Sci 2020; 24(2)508-516. DOI 10.26355/eurrev_202001_20026. PMID 32016952" has been withdrawn from the authors. The Publisher apologizes for any inconvenience this may cause.The article "Effect of miR-200c on migration and proliferation of breast cancer MDA-MB-231 cells and BT-549 cells and the possible mechanism, by Y. Lei, Y. Ma, Y. Liu, X.-F. check details Wang, published in Eur Rev Med Pharmacol Sci 2020; 24(2)735-739. DOI 10.26355/eurrev_202001_20053. PMID 32016976" has been withdrawn from the authors. The Publisher apologizes for any inconvenience this may cause.Not Available.The article "Effect of exosomes derived from mir-126-modified mesenchymal stem cells on the repair process of spinal cord injury in rats, by B. Yuan, S. Pan, Y.-Q. Dong, W.-W. Zhang, X.-D. He, published in Eur Rev Med Pharmacol Sci 2020; 24(2)483-490. DOI 10.26355/eurrev_202001_20025. PMID 32016949" has been withdrawn from the publisher for plagiarism. The Publisher apologizes for any inconvenience this may cause.OBJECTIVE To summarize the current practice and potential strategy in diagnosing coronavirus disease 2019 (COVID-19). MATERIALS AND METHODS PubMed, Web of Science were systematically searched using terms including "COVID-19", "SARS-CoV-2" and "2019-nCoV". After removing duplicates, we then identified articles, letters and commentaries regarding diagnosing COVID-19. RESULTS Here we summarized relatively mature diagnostic methods like nuclear acid test and computed tomography. Besides, new aspects regarding these detection methods like suitable specimens for nuclear acid test, possible use of 18F-FDG PET/CT were also reported. Especially, we also presented several novel techniques for diagnosing COVID-19 like lung ultrasound. CONCLUSIONS Chinese Clinical Guidance for COVID-19 Pneumonia Diagnosis and Treatment (7th edition) by National Health Commission is recommended to follow as it provides detailed diagnostic procedures using currently available tools. We suggest clinicians further explore the saliva's utility as a specimen for nuclear acid test and the use of lung ultrasound.OBJECTIVE To illustrate the role of micro ribonucleic acid (miR)-330-5p in regulating osteogenesis through biglycan (Bgn)-mediated bone morphogenetic protein (BMP)/Smad pathway. MATERIALS AND METHODS A mouse model of osteoporosis (OP) was established by ovariectomy (OVX). BMD and miR-330-5p levels in mice undergoing sham operation or OVX were determined. BMD and BV/TV in OP mice with in vivo knockdown of miR-330-5p were measured by Micro-CT. After silencing of miR-330-5p in mouse primary bone marrow stromal cells (BMSCs), expression changes in osteogenesis-associated genes, ALP activity, and mineralization ability were assessed. Subsequently, the interaction between miR-330-5p and Bgn was examined by Dual-Luciferase reporter gene assay and Western blotting. Then, Bgn levels in BMSCs undergoing osteogenesis at different time points were measured. At last, the regulatory effects of miR-330-5p/Bgn axis on the BMP/Smad pathway, ALP activity, and mineralization ability in BMSCs were evaluated. RESULTS BMD was decreased and miR-330-5p was upregulated in OP mice. OP mice with in vivo knockdown of miNA-330-5p presented higher BMD and BV/TV than controls. Transfection with miR-330-5p inhibitor upregulated osteogenesis-associated genes, ALP activity, and mineralization ability in BMSCs. Bgn was time-dependently upregulated in BMSCs undergoing osteogenesis, which was indicated to be the target gene of miR-330-5p. Besides, Bgn level was negatively regulated by miR-330-5p. Importantly, Bgn was able to reverse the regulatory effects of miR-330-5p on the BMP/Smad pathway, ALP activity, and mineralization ability in BMSCs. CONCLUSIONS Knockdown of miR-330-5p facilitates osteogenesis in BMSCs through the Bgn-induced BMP/Smad pathway, thus alleviating the progression of OP.The article "Regulatory effect of lncRNA NKILA on autophagy induced by sepsis kidney injury, by Y.-M. Yang, Y.-H. Li, L.-L. Ding, Y. Fu, N. Li, published in Eur Rev Med Pharmacol Sci 2019; 23(18)8011-8017. DOI 10.26355/eurrev_201909_19017. PMID 31599426" has been withdrawn from the authors. The Publisher apologizes for any inconvenience this may cause.The article "Long noncoding RNA NORAD promotes the progression of retinoblastoma by sponging miR-136-5p/PBX3 axis, by X.-L. Yang, Y.-J. Hao, B. Wang, X.-L. Gu, X.-X. Wang, J.-F. Sun, published in Eur Rev Med Pharmacol Sci 2020; 24(3)1278-1287. DOI 10.26355/eurrev_202001_20185. PMID 32096159" has been withdrawn from the authors. The Publisher apologizes for any inconvenience this may cause.The article "Clinical efficacy and prognosis of aspirin combined with clopidogrel in patients with cerebral hemorrhage after operation, by X.-J. Guo, W.-L. Ding, H.-H. Zhu, published in Eur Rev Med Pharmacol Sci 2020; 24(4)2087-2094. DOI 10.26355/eurrev_202002_20388. PMID 32141578" has been withdrawn from the authors. The Publisher apologizes for any inconvenience this may cause.COVID-19 pandemic can cause irreparable damage to the involved society. This study aimed to provide a summary of the up-to-dated clinical display, diagnostics, molecular and genetic implications for COVID-19 infected patients. In this review, 73 research articles published before 25 March 2020 were analyzed to better understand the clinical characteristics of patients and to introduce the available serological, hematology and molecular diagnostic methods. Apart from articles extracted from PubMed and Google Scholar, WHO (https//www.who.int/), NHC (National Health Commission of the People's Republic of China (http//www.nhc.gov.cn/), NICE (National Institute for Health and Clinical Excellence, https//www.nice.org.uk/), CDC (Centers for Disease Control and Prevention, https//www.cdc.gov/), and National Administration of Traditional Chinese Medicine (http//www.satcm.gov.cn/) were also accessed to search for eligible studies. Papers published between January 1, 2020, and 25 March 2020 were searched in English and the terms "2019-nCoV, Covid-19, Clinical Characteristics OR manifestation, method of detection, COVID-19 Genome and molecular test" were used.