Kroghscarborough6736

In clinical trials, several covariate-adaptive designs have been proposed to balance treatment arms with respect to key covariates. Although some argue that conventional asymptotic tests are still appropriate when covariate-adaptive randomization is used, others think that re-randomization tests should be used. In this manuscript, we compare by simulation the performance of asymptotic and re-randomization tests under covariate-adaptive randomization. Our simulation study confirms results expected by the existing theory (e.g. asymptotic tests do not control type I error when the model is miss-specified). Furthermore, it shows that (i) re-randomization tests are as powerful as the asymptotic tests if the model is correct; (ii) re-randomization tests are more powerful when adjusting for covariates; (iii) minimization and permuted blocks provide similar results.The objective of this study was to determine the prevalence of amphetamine-type stimulant use and associated factors among methadone maintenance treatment (MMT) patients. In 2018, a cross-sectional study was conducted on 967 MMT patients at two methadone clinics in Ho Chi Minh City that serve Vietnamese patients. Amphetamine-type stimulant use was assessed by rapid urine test and face-to-face interview using the Alcohol, Smoking, Substance Involvement Screening Test (ASSIST) tool. The prevalence of amphetamine-type stimulant use assessed by urine test was 25.4%. According to ASSIST, the prevalence of moderate and high risk amphetamine-type stimulant use was 15.5% and 1.1%, respectively. Amphetamine-type stimulant use and hazardous use were more prevalent in younger patients, having a part-time job, drug injection, having a lower score of self-health assessment, treated with a higher dose of methadone and missing methadone dose in the past 3 months. By contrast, patients who were HIV positive were less likely to use amphetamine-type stimulants. Cannabis and heroin use were significantly associated with amphetamine-type stimulant use (OR = 1.46; 95% CI 1.38-8.67; and OR = 1.50; CI 1.04-2.18, respectively) and hazardous use (OR = 4.07; CI 1.67-9.92; and OR = 2.38; CI 1.56-3.63, respectively). Screening and interventions are needed to cope with this issue on time, particularly in young patients, having drug injection and concurrent drugs user groups.

The purpose of this study is to explore experiences with daily challenges and the development of salutogenic copings skills among young adults with serious mental illness.

Nine young adults with serious mental illness were interviewed. The interviews were transcribed and subjected to reflexive thematic analysis.

Two main themes were identified through the analysis "The influence of symptoms in everyday life and challenges with participating in the community" and "Making the small things matter." The findings show that different life experiences, or on-going challenges, often can affect or interfere their lives on a daily basis, and that previous experiences with psychosis can contribute to the development of salutogenic coping skills.

This study shows the importance of increased knowledge and awareness of different life experiences and challenges among people with serious mental illness such as schizophrenia spectrum disorders. It is significant to strengthen the ability to identify and use appropriate resistance resources to promote salutogenic coping skills and thus better health. Furthermore, it is important to be aware that the development of salutogenic coping skills must be personalized to cultural contexts and society as well as supported by local communities, families and services.

This study shows the importance of increased knowledge and awareness of different life experiences and challenges among people with serious mental illness such as schizophrenia spectrum disorders. It is significant to strengthen the ability to identify and use appropriate resistance resources to promote salutogenic coping skills and thus better health. Furthermore, it is important to be aware that the development of salutogenic coping skills must be personalized to cultural contexts and society as well as supported by local communities, families and services.Dose-response models express the effect of different dose or exposure levels on a specific outcome. In meta-analysis, where aggregated-level data is available, dose-response evidence is synthesized using either one-stage or two-stage models in a frequentist setting. We propose a hierarchical dose-response model implemented in a Bayesian framework. We develop our model assuming normal or binomial likelihood and accounting for exposures grouped in clusters. To allow maximum flexibility, the dose-response association is modelled using restricted cubic splines. We implement these models in R using JAGS and we compare our approach to the one-stage dose-response meta-analysis model in a simulation study. We found that the Bayesian dose-response model with binomial likelihood has lower bias than the Bayesian model with normal likelihood and the frequentist one-stage model when studies have small sample size. When the true underlying shape is log-log or half-sigmoid, the performance of all models depends on choosing an appropriate location for the knots. In all other examined situations, all models perform very well and give practically identical results. We also re-analyze the data from 60 randomized controlled trials (15,984 participants) examining the efficacy (response) of various doses of serotonin-specific reuptake inhibitor (SSRI) antidepressant drugs. All models suggest that the dose-response curve increases between zero dose and 30-40 mg of fluoxetine-equivalent dose, and thereafter shows small decline. We draw the same conclusion when we take into account the fact that five different antidepressants have been studied in the included trials. We show that implementation of the hierarchical model in Bayesian framework has similar performance to, but overcomes some of the limitations of the frequentist approach and offers maximum flexibility to accommodate features of the data.The primary purpose of this study was to evaluate performance on the Memory Validity Profile (MVP) in a mixed pediatric clinical population. Goal 1, assessing MVP pass rates, yielded a slightly higher pass rate (98.58%) compared to research on other performance validity tests (PVTs) in youth when using manual-based cutoffs and a slightly lower pass rate (84.40%) using an experimental cutoffs (PASS Total ≥31) similar to others' research. Goal 2, determining if MVP performance was contingent on variables other than effort, yielded significant differences in age, sex, and intelligence (p less then 0.05); but not parental education or occurrence/nonoccurrence of previous neurological issues, ADHD, or psychiatric disorders. Goal 3, investigating the agreement of an embedded PVT (Children and Adolescent Memory Profile [ChAMP] List Recognition [LR] subtest) with the MVP in classification of adequate vs. suboptimal effort, showed that the highest levels of consistency (81%) were achieved when experimental MVP and LR ss ≤5 cutoffs were utilized. In conclusion, the MVP is a useful tool in detecting suboptimal effort in children in a broad clinical sample and the ChAMP LR subtest adds to identification of suboptimal effort as an ePVT with the MVP. The established cutoffs stated in the MVP manual should be used, as these better identify suboptimal effort in children by age than experimental cutoffs (i.e., 31 and 32 PASS). The ChAMP LR cutoff should be ss ≤5, with MVP manual-based (75%) or experimental cutoffs (81%).Transcranial direct current stimulation (tDCS) has been shown to induce changes in cortical excitability and perfusion in a rat ischemic stroke model. Since perfusion disturbances are a common phenomenon, not only in ischemic but also in hemorrhagic stroke, tDCS might have a possible beneficial effect on cerebral perfusion in hemorrhagic stroke as well. We applied tDCS in a rat model of subarachnoid hemorrhage (SAH) and evaluated its impact on vasospasm. SAH was induced using the double-hemorrhage rat model. TDCS was applied on day 3 and 4. For vasospasm assessment magnetic resonance angiography was performed on day 1, day 2 and day 5. A total of 147 rats were operated, whereat 72 rats died before day 5 and 75 rats survived the whole experiment and could be analyzed. The cathodal group consisted of 26 rats, the anodal group included 24 rats. Thirteen rats served as controls without tDCS, and twelve rats underwent a sham operation. The cathodal group revealed the lowest incidence of new vasospasm on day 5 (p = 0.01), and the lowest mean number of vasospastic vessels per rat (p = 0.02). TDCS influences the vasospasm incidence in an SAH-model in rats, where cathodal-tDCS was associated with a lower vasospasm incidence and severity.Objectives. Safety assessment helps the development of continuous improvement strategies in construction safety, especially coping with dynamic changes to the on-site environment with uncertainties. This article proposes a composite safety assessment based on on-site conditions to facilitate improved and proactive construction safety management. Methods. First, based on evident rectification records, we utilized set pair analysis, a grey rough approach and a coevolution approach to quantify overall safety performance. Second, we incorporated two safety performance indicators into a composite assessment framework, using rough set theory and fluid dynamics. Finally, the assessment results of the seven completed projects were compared. Results. The coevolution approach had novel advantages in assessing rectification performance and the fluid dynamics approach could enhance the proactive warning ability of the safety assessment. Conclusion. Theoretically, the research contributes to new insights into the quantification of construction safety assessment under dynamic on-site conditions. Practically, it also contributes to the active and objective measurement of management performance and promotes the dynamic and stable safety performance evaluation for on-site construction.Substantial evidence has demonstrated that sexual dysfunction is negatively associated with the sexual satisfaction of individuals in a committed heterosexual relationship. Tebipenem Pivoxil clinical trial However, little is known about their relationship based on couple data, especially in non-Western societies. We extended this study to examine the extent to which men's and women's sexual dysfunction were associated with their own as well as their partners' sexual satisfaction. Participants were 1,014 heterosexual couples who participated in a community-based survey in Hong Kong in 2017. Using the actor-partner interdependence model and structural equation modeling, our results indicated that the dyadic model fit the data better than the individual model. Women's orgasm and men's sexual desire functioning were significant predictors of both own and partner's sexual satisfaction, and these two domains had similar effects on the sexual satisfaction of both men and women. These findings are discussed in terms of the importance of taking a dyadic approach to research and enhance sexual health and well-being of heterosexual couples.