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7%), and minor postoperative bleeding occurred in 12 of the 479 patients with recorded follow-up (2.5%). There were no postoperative bleeds requiring intervention or readmission, and no recorded thrombotic events during the peri- and postoperative period. There was no difference in perioperative bleeding based on baseline antithrombotic status (P = .81). Patients on baseline antithrombotic therapy were more likely to have a postoperative bleed in comparison to patients without history of antithrombotic use (P  less then  .01). However, there were no significant differences in postoperative bleeding between patients on baseline anticoagulation who continued or ceased their medication perioperatively (P = .45). CONCLUSIONS Perioperative continuation of antithrombotic medications appears to be safe when performing routine DML. LEVEL OF EVIDENCE 4 Laryngoscope, 2020. © 2020 The American Laryngological, Rhinological and Otological Society, Inc.The periodontium is a highly hierarchically organized organ composed of gingiva, alveolar bone, periodontal ligament and cementum. Periodontitis leads to the destruction of hard and soft tissues ultimately leading to a loss of the teeth supporting apparatus. Current treatments are capable of limiting the disease progression; however, true regeneration, characterized by perpendicularly oriented periodontal ligament fibre attachment to cementum on the root surface remains challenging. Tissue engineering approaches have been developed to enhance regeneration via micro-engineered topographical features, purposely designed to guide the insertion of the regenerated ligament to the root surface. This review reports on the recent advancements in scaffold manufacturing methodologies for generating fibre guiding properties and provides a critical insight in the current limitations of these techniques for the formation of functional periodontal attachment. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.EWSR1-PATZ1 is a rare gene fusion recently recognized to occur in round and spindle cell sarcomas. To date, fewer than 20 cases have been described in the literature. However, no dedicated case reports have detailed its presentation in the head and neck region. We recently cared for a 52-year-old woman with an isolated, single right level 5A cervical mass. Excisional biopsy at an external hospital revealed pathology results consistent with EWSR1-PATZ1 polyphenotypic round and spindle cell sarcoma. The patient subsequently underwent surgical excision of the tumor and right neck lymph node dissection followed by adjuvant chemoradiation. Laryngoscope, 2020. © 2020 The American Laryngological, Rhinological and Otological Society, Inc.OBJECTIVES Much of the research previously done on diabetic ketoacidosis (DKA) was based on a young population with type 1 diabetes mellitus (type 1 DM). But substantial numbers of DKA episodes occur in patients with a prior history of type 2 diabetes mellitus (type 2 DM). There is a lack of Data are lacking about DKA in older adults. The aims of this study were to analyze the clinical characteristics and outcomes of older adult patients with DKA. DESIGN Retrospective matched cohort study of adult patients hospitalized with DKA between 2004 and 2017. Oxiglutatione in vivo SETTING Soroka University Medical Center, Be'er Sheva, Israel. PARTICIPANTS The clinical characteristics of DKA patients 65 years and older were compared with patients younger than 65 years. MEASUREMENTS The primary outcome was in-hospital mortality. RESULTS The study cohort included 385 consecutive patients for whom the admission diagnosis was DKA 307 patients (79.7%) younger than 65 years (group 1), and 78 patients (20.3%) older than 65 years (group 2). Patients in group 2 compared with group 1 had a significantly higher Charlson index (6 [6-6] vs 6 [6-7]; P less then .0001) and DM with target organ damage (24.4% vs 6.2%; P less then .0001). Patients in group 2 compared with group 1 had more serious disease according to results of laboratory investigations. The total in-hospital mortality rate of patients in group 2 was 16.7% compared with 1.6% in patients in group 1 in a sex and co-morbidities matched analysis (P = .001). CONCLUSIONS DKA in older adults is a common problem. The serious co-morbidities and precipitating factors such as infection/sepsis, myocardial infarction, and cerebrovascular accidents, may explain the severity of the problem of DKA in older adults and the high rate of mortality of these patients. DKA appears to be a lifethreatening condition in older adults. The alertness of physicians to DKA in older adults, timely diagnosis, proper treatment, and prevention are cornerstones of care. © 2020 The American Geriatrics Society.BACKGROUND Rare earth elements (REEs) played an important role in enhancing the yield and quality of tea, and have been widely used in tea cultivation. In the present study, 3011 tea samples of four tea types, namely black tea, green tea, oolong tea and dark tea, were collected from the mainly tea producing areas in different provinces of China to analyze the contents of 16 REEs by inductively coupled plasma mass spectrometry. RESULTS The results obtained showed that the higher average content of REEs was 2.960 mg kg-1 in black tea from Henan province, 2.500 mg·kg-1 in green tea from Shanxi province, 3.870 mg·kg-1 in oolong tea from Guizhou province and 2.955 mg·kg-1 in dark tea from Hunan province. The sum percentage of five elements (Sc, Y, La, Ce, and Nd) to total REEs was 84.39% in black tea, 85.07% in green tea, 83.67% in oolong tea and 84.42% in dark tea. In addition, the content of Ce in tea was greatest, regardless of the province of China. The content trend of the five REEs was Ce > La > Sc > Nd > Y in black and green tea, respectively. However, the content trend was Ce > Y > Sc > Nd > La in oolong tea and Ce > Y > La > Nd > Sc in dark tea. CONCLUSION The tea leaves mainly accumulated light REEs rather than heavy REEs. These results provided an important theoretical basis for investigation of the accumulation characteristics of REEs in Chinese tea. © 2020 Society of Chemical Industry. © 2020 Society of Chemical Industry.