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Psoriasis is a chronic, immune-mediated dermatologic disorder with a prevalence among children estimated at 0.1%-0.45%, and a median age of onset at approximately 7-10years. Pediatric psoriasis is known to have negative impacts on health-related quality of life. Among the most bothersome symptoms, itch has been measured using the Itch Numeric Rating Scale (NRS). This study explored the symptom and impacts of itch with pediatric psoriasis patients and evaluated the content validity of the Itch NRS in children.

Semi-structured qualitative interviews were conducted among a sample of pediatric patients diagnosed with plaque psoriasis.

Concept elicitation interviews were completed with 22 children (ages 7-17years). When asked about most frequent symptoms, 61% reported itching (n=14) and 65% reported flaking (n=15). The majority reported itching as bothersome; about half described impacts on their regular activities. Cognitive interviews were completed with 25 children (ages 8-17years). Most reported that independently completing the Itch NRS would be easy, and all described the meaning of the response options similar to the intended value. selleck inhibitor Overall, the Itch NRS was received favorably, with comments that the scale was easy or relevant to their experience with psoriasis.

This qualitative study supports the content validity of the Itch NRS for use in a pediatric psoriasis population aged 8-17. Given the established importance of itch to pediatric psoriasis patients, future research exploring the impact of itch on the lives of pediatric psoriasis patients may provide a valuable contribution to the field.

This qualitative study supports the content validity of the Itch NRS for use in a pediatric psoriasis population aged 8-17. Given the established importance of itch to pediatric psoriasis patients, future research exploring the impact of itch on the lives of pediatric psoriasis patients may provide a valuable contribution to the field.A variety of rodents have been used as experimental animals in metabolic studies of plasma lipids and lipoproteins. These studies have included understanding the functional role of apolipoprotein A-I, the major protein on the surface of HDL. Reviewing the genomic database for entries for rodent apoA-I genes, it was discovered that the naked mole-rat (Heterocephalus glaber) gene encoded a protein with a cysteine at residue 28. Previously, two cases have been reported in which human heterozygotes had apoA-I with cysteine at residues 173 (apoA-I Milano) or at 151 (apoA-I Paris). Interestingly, both groups, in spite of having low levels of HDL and moderately elevated plasma triacylglycerols, had no evidence of cardiovascular disease. Moreover, the presence of the cysteine enabled the apoA-I to form both homodimers and heterodimers. Prior to this report, no other mammalian apoA-I has been found with a cysteine in its sequence. In addition, the encoded naked mole-rat protein had different amino acids at sites that were conserved in all other mammals. These differences resulted in naked mole-rat apoA-I having an unexpected neutral pI value, whereas other mammalian apoA-I have negative pI values. To verify these sequence differences and to determine if the N-terminal location of C28 precluded dimer formation, we conducted mass spectrometry analyses of apoA-I and other proteins associated with HDL. Consistent with the genomic data, our analyses confirmed the presence of C28 and the formation of a homodimer. Analysis of plasma lipids surprisingly revealed a profile similar to the human heterozygotes.

In Egypt, primary healthcare workers (PHCWs) often work in challenging situations and in relative isolation from the health system and specialists' experiences. Supervision is currently applied by PHCWs to present practice, control and upgrade knowledge and skills.

To assess the current supervision system in the Ministry of Health and Population (MOHP) at the central, governorate, district, and primary healthcare (PHC) facility levels.

The research setting is the MOHP-PHC head quarter (HQ) and five governorates.

Cross-sectional analytical observational health system research qualitative and quantitative study of Egyptian health service and operations.

The multistage sampling technique was used to select districts (n=25) units (n=250), physicians (n=250), and nurses (n=250) from five randomly selected governorates that represent four Egypt regions.

Focus group discussions (FGDs) and self-administered questionnaires.

Response rate to questionnaires were in total 73% (67% for physicians and 80% for personal and professional upgrade and development and improved problem-solving skills at the facility level.

Dravet syndrome (DS) is a severe, drug-resistant, developmental epileptic encephalopathy. Despite multiple anti-epileptic drug regimens, the syndrome remains poorly controlled and nearly half of patients still experience at least four tonic-clonic seizure per month. Recently, several clinical trials demonstrated that fenfluramine may provide a significant reduction in convulsive seizure frequency in the treatment of Dravet syndrome.

A computerized literature search of Web of Science, MEDLINE (Ovid and PubMed), Cochrane Library, EMBASE, and Google Scholar was performed from inception until December 31, 2019. We included randomized placebo-controlled trials for the treatment of Dravet syndrome. We calculated the risk ratio (RR) of ≥50% and 100% reduction seizure frequency from baseline, along with the treatment-related withdrawals and serious adverse events, using the fixed-effect model. Quality assessment of included studies was performed with the Cochrane Collaboration's tool.

Two trials with a total oftic drug for pediatric patients with Dravet syndrome, demonstrating clinically meaningful reduction in convulsive frequency, and generally could be well tolerated.

Fenfluramine is an effective antiepileptic drug for pediatric patients with Dravet syndrome, demonstrating clinically meaningful reduction in convulsive frequency, and generally could be well tolerated.

Medical errors (MEs) are serious but preventable threats to patient safety. Annually, 421 million hospitalizations take place worldwide, from those an estimation of around 43 million MEs occur. Low-middle income countries account for two-thirds of these MEs.

To examine the prevalence and contributing factors predicting MEs and its reporting among Jordanian nurses and nursing students.

The study used a cross-sectional descriptive design. A total of 178 nursing students and 123 bedside nurses participated in this study. Study data were collected through a five-section newly developed survey.

MEs are highly prevalent in Jordanian hospitals. More than 70% of nurses and nursing students have no previous training in preventing and reporting MEs. The most prevalent type of MEs were related to changing positions for bedridden patients followed by medication errors, iatrogenic infections, and falls. Staff shortage was the main cause of MEs from participants' perspectives.

A central concern of these results is the need for providing effective programs on identifying and preventing MEs in health-care settings and integrate these programs into graduate nursing curriculums.