Kragelundseverinsen9500

Timely intravenous (IV) to oral antimicrobial switch (IV-oral-switch) is a key antimicrobial stewardship (AMS) strategy. We aimed to explore concordance with IV-oral-switch guidelines in the context of a long-standing, tightly regulated AMS program. Data was retrospectively collected for 107 adult general medical and surgical patients in an Australian hospital. Median duration of IV antimicrobial courses before switching to oral therapy was 3 days (interquartile range [IQR] 2.25-5.00). Timely IV-oral-switch occurred in 57% (n = 61) of patients. The median delay to switching was 0 days (IQR 0 to 1.25). In most courses (92/106, 86.8%), the choice of oral alternative after switching was appropriate. In 45% (47/105) of courses, total duration of therapy (IV plus oral) exceeded the recommended duration by >1.0 day. Excessive IV antimicrobial duration was uncommon at a hospital with a tightly regulated AMS program. Total duration of therapy was identified as an AMS target for improvement.

We utilised chromogenic and fluorescencein-situhybridisation (CISH and FISH) to evaluate MYCgene copy numbers and rearrangements within HIV-associated plasmablastic lymphomas (PBLs). JAK pathway Thereafter, clinicopathological features were explored retrospectively.

Sixty-seven (n=67) patients were included and the HIV seropositive status was confirmed in 98% (63 of 64) with a median viral load of 55 587 (IQR 273 582) copies/ml and median CD4 count of 170 (IQR 249) cells/µl. The mean age was 41 ± 10.1 years and females comprised 54%. PBL was documented predominantly at extra-oronasal topographic regions. Starry-sky (SS) appearance was evident in 33% in association with monomorphic morphology (P-value 0.02). c-MYC protein was expressed in 81% and latent EBV infection was detected in 90%. EBER ISH-positive status and MYC rearrangement occurred in 67% of HIV PBL. MYC aberrations included MYC rearrangement (70%), low-level increase in MYCgene copy numbers (43%), concurrent MYC rearrangement and increased MYC gene copy numbers (49%) as well as low-level chromosome 8 polysomy (6%). MYC aberrations in HIV PBLs were significantly associated with SS appearance (P -0.01), monomorphic morphology (P - 0.03), c-MYC protein expression ≥40% (P - 0.03) and mortality (P - 0.03). There was advanced stage (Ann Arbor III/IV) at presentation (77%) and the median overall survival for HIV PBL was 75days (95% CI 14-136).

Majority of the HIV-associated PBL tumours harbour MYC aberrations. Due to the persistently inferior survival outcome of HIV-associated PBL in the era of antiviral treatment, targeted and/or intensified therapy of oncogenic MYC may need to be explored in future.

Majority of the HIV-associated PBL tumours harbour MYC aberrations. Due to the persistently inferior survival outcome of HIV-associated PBL in the era of antiviral treatment, targeted and/or intensified therapy of oncogenic MYC may need to be explored in future.

Up to 50% of child abuse (CA) victims exhibit evidence of traumatic facial or intraoral injuries. Dental health professionals (DHPs) are therefore well-positioned to detect and report incidences of CA. This study aimed to assess the knowledge and attitudes of Western Australian DHPs towards identifying and reporting CA.

General dentists, specialists, hygienists and oral health therapists completed an online questionnaire which assessed their knowledge and experience in identifying and reporting CA.

A total of 228 participants completed the questionnaire (representing 7% of DHPs, 60% of paediatric dentists and 11% of all dental hygienists and therapists in Western Australia). The majority of participants (66.2%, P<0.05) felt that they were unlikely to recognize a patient with physical abuse, or detect signs of sexual abuse (90.8%, P<0.001). Uncertainty around diagnosing abuse was a barrier towards reporting cases (86.4%, P<0.05) and most participants (78.0%, P<0.05) felt that they did not have adequate safeguarding training to report CA.

Self-reported confidence in identifying and reporting CA cases was low; with the majority of the dental professionals participating in this study unlikely to recognize signs of CA. Inadequate training and knowledge around correct reporting protocols were identified as barriers, which warrants an appropriate change to improve child safeguarding.

Self-reported confidence in identifying and reporting CA cases was low; with the majority of the dental professionals participating in this study unlikely to recognize signs of CA. Inadequate training and knowledge around correct reporting protocols were identified as barriers, which warrants an appropriate change to improve child safeguarding.

For a given passively-distributed lipophilic drug, the extent of in vivo distribution (pharmacokinetic volume of distribution, V

) in obese individuals increases in relation to the degree of obesity. The present study had the objective of evaluating drug distribution in relation to in vitro lipophilicity, and the relative increase in V

associated with obesity across a series of drugs.

Cohorts of normal-weight control and obese subjects received single doses of drugs ranging from hydrophilic (acetaminophen, salicylate) to lipophilic (imipramine, verapamil). Lipid solubility was measured by the log-transformed values of the high-pressure liquid chromatographic (HPLC) retention index (Log

(HPLC)), and the octanol-water partition coefficient (LogP).

Among normal-weight controls, V

normalized for protein binding was highly correlated with Log

(HPLC) (R

= .65) and with LogP (R

= .78). V

of all drugs was increased in the obese cohort, but the relative increase (compared to controls) for individhis effect for a given drug depends on the degree of obesity, as well as the lipid-solubility of the specific drug.Temporal orienting of attention can affect multiple stages of processing to guide adaptive behaviour. We tested whether temporal expectation in different task contexts is compromised in individuals with Parkinson's disease (PD). In Experiment 1 two temporal-orienting tasks were used a speeded task emphasizing motor preparation and a non-speeded task emphasizing perceptual discrimination using rapid serial visual presentation. In both tasks, auditory cues indicated the likelihood of a target appearing after a short or long interval. In the speeded-response task, participants used the cues to anticipate an easily detectable target stimulus. In the non-speeded perceptual-discrimination task, participants used the cues to help discriminate a target letter embedded in a stream of letters. Relative to healthy participants, participants with PD did not show altered temporal orienting effects in the speeded-response task. However, they were impaired in using temporal cues to improve perceptual discrimination. In Experiment 2, we tested whether the temporal-orienting deficits in the perceptual-discrimination task depended on the requirement to ignore temporally distracting stimuli.