Koldingsingleton4706

05) and significantly lower in the T

weighted in-phase aspect of the RAVE T

/T

hybrid sequence compared to the T

DIXON sequence (p<0.05). Qualitatively the T

weighted aspect of the RAVE T

/T

hybrid sequence was rated significantly higher than the T

HASTE in 6 of 7 categories (p<0.05) and the T

weighted in-phase aspect of the RAVE T

/T

hybrid sequence was rated significantly higher than the T

DIXON in 2 of 6 categories (p<0.05).

The abdominal radial RAVE T

/T

hybrid sequence provided higher image quality and SNR than the T

HASTEsequence. Together with increased robustness against motion artifacts, the RAVE T

/T

hybrid sequence appears to be a good tool for abdominal imaging in CF patients.

The abdominal radial RAVE T2/T1 hybrid sequence provided higher image quality and SNR than the T2HASTEsequence. Together with increased robustness against motion artifacts, the RAVE T2/T1 hybrid sequence appears to be a good tool for abdominal imaging in CF patients.Non-alcoholic fatty liver disease (NAFLD) affects almost one quarter of adults worldwide, and its progressive subtype, non-alcoholic steatohepatitis can progress to advanced fibrosis/cirrhosis and even hepatocellular carcinoma. It is critical to screen and grade NAFLD patients for management decisions to rationalize the utilization of medical resources. Conventional ultrasound is widely applied for NAFLD screening, however, some inherent weaknesses hinder its utility. This limitation has spurred the development of acoustic parameters-based quantitative ultrasound techniques that allow a more accurate evaluation of the histological features of NAFLD (e.g. steatosis, necroinflammation, fibrosis/cirrhosis). Herein, this paper reviews the research advances in emerging ultrasound techniques for screening and surveillance across NAFLD spectrum and summarize their principles, feasibility, accuracy, reproducibility, and limitations of each technique. The challenges and future directions are also discussed to advance clinical practice.

To evaluate the outcome of dual-vessel intervention (DVI), including bronchial or pulmonary arterial embolization (B/PAE), in managing massive hemoptysis caused by cavitary lung lesions (with or without aspergilloma) and identify cavitary angiographic features influencing DVI procedures.

A retrospective analysis of the medical records and angiograms of 15 patients who underwent DVI for massive hemoptysis was performed.

The most frequent causes of cavitary lung lesions were tuberculosis (TB) (8/15, 53%) and bronchiectasis (6/15, 40%). Eight patients were diagnosed with aspergilloma (8/15, 53%). In all, 24 systemic arteries, including the orthotopic and ectopic bronchial arteries and 1 pulmonary artery branch, were embolized in 16 procedures. Clinical success and immediate cessation of hemoptysis were achieved in 12 patients (80%). Hemoptysis was controlled in 10 patients (67%) and recurred in 2 patients (17%), while 1 patient (7%) required repeat embolization. The bronchopulmonary fistula (shunting) rate fistula type, and fistula emergence time.

To develop and validate an

F-FDG PET/CT radiomics nomogram for non-invasive differentiation of high-risk and non-high-risk patients of the International Neuroblastoma Risk Group (INRG) Staging System (INRGSS).

One hundred thirty-nine neuroblastoma patients were retrospectively enrolled and classified into a training set (n=84) and validation set (n=55). Radiomics features were extracted from

F-FDG PET/CT images, a radiomics signature was constructed, and a radiomics score (Rad score) was calculated. Then, univariate and multivariate logistic regression analyses were used to screen out the independent clinical factors and construct the clinical model. A radiomics nomogram was developed based on the Rad score and independent clinical factors. The performance of the clinical model, Rad score, and nomogram was assessed by receiver operating characteristic (ROC) curves, calibration curves, and decision curves analysis (DCA).

Seven radiomics features were selected to build the radiomics signature. The agease follow-up and management in clinical practice and assist in personalized and precise treatment of neuroblastoma.

Adolescents and young adults with abuse-related post traumatic stress disorder (PTSD) have been shown to benefit from Developmentally Adapted Cognitive Processing Therapy (D-CPT), yet long-term efficacy of D-CPT has not yet been studied.

To assess the long-term efficacy of D-CPT in a sample of adolescents and young adults (age 14-21years) with childhood abuse related PTSD.

Patients of a previously conducted multicenter randomized controlled trial which showed the efficacy of D-CPT compared to a waitlist with treatment advice (WL/TA) were invited for follow-up assessments at 6 and 12months after the end of treatment.

Primary outcome was the PTSD symptom severity, assessed with the Clinician-administered PTSD Scale for Children and Adolescents (CAPS-CA). Secondary outcomes were self-reported PTSD severity, depression, borderline symptom severity, behavior problems, and dissociation.

Of the 44 participants who received D-CPT, 28 (63%) responded and were assessed at 6-month follow-up. At 12-month follow-up, 22 participants (50%) responded. The majority of participants in the WL/TA group received D-CPT after the end of the trial and were hence not available for follow-up assessment. In the D-CPT group, treatment gains were maintained at 6- and 12-month follow-up in the CAPS-CA as well as in all secondary outcomes.

The positive effects of D-CPT were stable in adolescents and young adults with abuse-related PTSD indicating that they can benefit in the long term from a treatment with D-CPT.

The positive effects of D-CPT were stable in adolescents and young adults with abuse-related PTSD indicating that they can benefit in the long term from a treatment with D-CPT.

Parental neglect has been shown to be associated with adolescents' peer alienation. However, few previous studies have considered parental phubbing as a new form of social neglect during parent-child interactions related to adolescents' peer alienation, and much less is known about the mechanisms underlying this relationship.

The present study explored the relationship between father phubbing (Fphubbing) and mother phubbing (Mphubbing) and adolescents' peer alienation. Moreover, it examined whether adolescents' perceived paternal and maternal rejection mediate these associations.

A sample of 1140 students (M

=12.18years, SD=0.90) completed the measures of parental phubbing, parental rejection, and peer alienation.

Structural equation modeling was used to assess the direct effects of Fphubbing and Mphubbing on adolescents' peer alienation and their indirect effects through adolescents' perceived paternal and maternal rejection as mediators.

The results indicated that Fphubbing and Mphubbing were positively related to adolescents' peer alienation. Perceived maternal rejection mediated the relationship between Mphubbing and adolescents' peer alienation. The relationship between Mphubbing and maternal rejection was stronger for adolescent girls.

Our study offers a preliminary understanding of how parental phubbing associates with adolescents' peer alienation through the mediating role of adolescents' perceived parental rejection, which has certain theoretical and practical implications for comprehending adolescents' peer alienation in the mobile age.

Our study offers a preliminary understanding of how parental phubbing associates with adolescents' peer alienation through the mediating role of adolescents' perceived parental rejection, which has certain theoretical and practical implications for comprehending adolescents' peer alienation in the mobile age.

Childhood maltreatment continues to pose a great challenge to psychiatry. Although there is growing evidence demonstrating that childhood maltreatment is an important risk factor for depressive disorders, it remains to be elucidated which specific symptoms occur after exposure to different kinds of childhood maltreatment, and whether certain pathways may account for these associations.

A total of 203 adult patients (18-53years old) with MDD, diagnosed by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria, were recruited from the outpatient clinic of Beijing Anding Hospital, Capital Medical University.

Childhood maltreatment, depressive symptoms, functional impairment, and quality of life were evaluated by the Childhood Trauma Questionnaire - Short Form (CTQ-SF), 17-item Hamilton Depression Rating Scale (HAMD-17), Sheehan Disability Scale (SDS), and Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF). Proteases inhibitor Undirected network analysis was used to explore the most relevant connections between them. Bayesian network analysis was used to estimate a directed acyclic graph (DAG) while investigating the most likely direction of the putative causal association.

In network analysis, the strongest edges were a positive correlation between emotional abuse and suicidal behavior as well as a negative association between emotional neglect and age of onset. In DAG analysis, emotional abuse emerged as the most pivotal network node, triggering both suicidal behaviors and depression symptoms.

Emotional abuse appears to be an extremely harmful form of childhood maltreatment in the clinical presentation of depression. This study has promise in informing the clinical intervention of depression.

Emotional abuse appears to be an extremely harmful form of childhood maltreatment in the clinical presentation of depression. This study has promise in informing the clinical intervention of depression.Bis-Schiff's base derivatives of 4-nitroacetophenone (1-18) were synthesized in good yields by reacting hydrazone of 4-nitroacetophenone with substituted aldehydes and ketones with catalytic amount of acetic acid. The structures of synthesized products (1-18) were deduced with the help of spectroscopic techniques like 1H NMR, 13C NMR and HR-ESIMS. The synthesized bis-Schiff's bases were assessed for their α-glucosidase inhibitory activity where compound 4 (IC50 = 2.79 ± 0.04 µM), 1 (IC50 = 9.76 ± 0.31 µM), 6 (IC50 = 11.37 ± 0.20 µM), 17 (IC50 = 14.10 ± 0.12 µM), 14 (IC50 = 17.21 ± 0.28 µM), and 8 (IC50 = 20.73 ± 0.53 µM), showed a very high potential for inhibition of α-glucosidase. Compounds 11, 15, 16, 2, 18, 7, and 5 showed significant inhibition against alpha-glucosidase with IC50 values 22.98 ± 0.34, 24.45 ± 0.53, 27.31 ± 0.29, 40.56 ± 0.60, 41.58 ± 0.47, 46.53 ± 0.76, and 47.46 ± 0.89 µM, respectively. Furthermore, compound 10 (IC50 = 52.63 ± 0.74 µM), 12 (IC50 = 70.80 ± 3.59 µM), 3 (IC50 = 82.68 ± 0.69 µM), 13 (IC50 = 88.89 ± 4.25 µM), and 9 (IC50 = 94.58 ± 0.86 µM) showed moderate activity towards the inhibition of α-glucosidase enzyme. All these compounds were compared with acarbose (IC50 = 875.75 ± 1.24 µM) as a standard α-glucosidase inhibitor. Molecular docking was used to know the molecular bases of such high activities against α-glucosidase. High docking scores were recorded implying significant interactions between the active compounds and amino acid residues of the active site of α-glucosidase.