Kokholmhald3413

Presepsin, a biomarker for sepsis diagnosis, has not been studied in very elderly population. The study aimed to evaluate the diagnostic and prognostic value of Presepsin in very elderly patients compared to point-of-care Procalcitonin (PCT), C-reactive protein (CRP), and early warning scores (EWSs).

This study prospectively enrolled 250 patients aged at least 75years old, presenting to the Emergency Department of Siriraj Hospital with suspected sepsis during September 2019 and January 2020. They were classified into three groups non-sepsis, sepsis, and septic shock. Biomarkers and EWS values at admission were determined. PCT was analyzed with non-BRAHM method.

Presepsin had valuable diagnostic utility for sepsis (AUC 0.792), comparable to PCT (AUC 0.751, p=0.22) and CRP (AUC 0.767, p=0.47). It also showed similar prognostic accuracy (AUC 0.683) with PCT (AUC 0.691, p=0.68) and CRP (AUC 0.688, p=0.85). The combination of Presepsin, PCT, and an EWS yielded the highest diagnostic accuracy for sepsis and septic shock and highest prognostic accuracy for 30-day mortality.

Presepsin is a valuable diagnostic and prognostic biomarker for sepsis in very elderly emergency patients. The combination of Presepsin, PCT, and an EWS was the best modality for early sepsis diagnosis and prognostication.

Presepsin is a valuable diagnostic and prognostic biomarker for sepsis in very elderly emergency patients. The combination of Presepsin, PCT, and an EWS was the best modality for early sepsis diagnosis and prognostication.As a member of the ubiquitin-like protein family, the human leukocyte antigen F locus adjacent transcript 10 is composed of two ubiquitin-like domains that have high homology with ubiquitin. Studies have shown that abnormal FAT10 expression and FAT10ylation are crucial to many aspects of cellular biology, such as protein degradation, immune response, regulation of apoptosis and cell cycle progression. In this manuscript, we review some important biological roles of FAT10 in cardioprotection and tumor promotion. FAT10 may be cardioprotective in ischemia and hypoxia through attenuation of hypoxia-induced cardiomyocyte apoptosis regulated by the BCL2/BAX ratio and caveolin-3. 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