Koenigsherrill3259

Increasing evidence indicates the involvement of myocardial oxidative injury and mitochondrial dysfunction in the pathophysiology of heart failure (HF). Alpha-ketoglutarate (AKG) is an intermediate metabolite of the tricarboxylic acid (TCA) cycle that participates in different cellular metabolic and regulatory pathways. The circulating concentration of AKG was found to decrease with ageing and is elevated after acute exercise and resistance exercise and in HF. Recent studies in experimental models have shown that dietary AKG reduces reactive oxygen species (ROS) production and systemic inflammatory cytokine levels, regulates metabolism, extends lifespan and delays the occurrence of age-related decline. However, the effects of AKG on HF remain unclear. In the present study, we explored the effects of AKG on left ventricular (LV) systolic function, the myocardial ROS content and mitophagy in mice with transverse aortic constriction (TAC). AKG supplementation inhibited pressure overload-induced myocardial hypertrophy and fibrosis and improved cardiac systolic dysfunction; in vitro, AKG decreased the Ang II-induced upregulation of β-MHC and ANP, reduced ROS production and cardiomyocyte apoptosis, and repaired Ang II-mediated injury to the mitochondrial membrane potential (MMP). These benefits of AKG in the TAC mice may have been obtained by enhanced mitophagy, which cleared damaged mitochondria. In summary, our study suggests that AKG improves myocardial hypertrophy remodelling, fibrosis and LV systolic dysfunction in the pressure-overloaded heart by promoting mitophagy to clear damaged mitochondria and reduce ROS production; thus, AKG may have therapeutic potential for HF.

Over the last decade, per- and polyfluoroalkyl substances (PFASs) have become one of the most heavily investigated persistent organohalogen compound class of environmental concern. However, knowledge about their toxicology is still scarce, although PFASs as individual compounds and their industrial mixtures were shown to exert effects on the thyroid hormone system.

In vitro toxicity potency factors were established for thyroid hormone transport disruption potential using the novel TTR-TRβ CALUX® bioassay for major PFASs. We assessed technical PFASs mixtures, including aqueous film-forming foam (AFFF) surfactants and chromium mist suppressants (CMS) applications with and without total oxidizable precursor (TOP) by TTR-TRβ CALUX® assay for their thyroid hormone transport disrupting potential.

All PFASs listed in the German guideline for drinking water (German Environment Agency, 2017) affected the T4 binding to TTR, an important plasma thyroid hormone transport protein. For all tested PFASs, potency factos from PFASs measured directly by the TTR-TRβ CALUX® assay. This study supports the claim that semiquantitative effect- and group-based in vitro CALUX bioanalysis tools can be applied effectively to assess industrial products containing complex mixtures with PFAS compounds for which no instrumental analysis are established, and for many compounds where in vitro toxicity data are not yet available.The photocatalytic degradation of pharmaceutical micropollutants of Penicillin G (PG) was investigated in a photoreactor at a laboratory scale. The impact of type of catalyst, pH, and initial concentration of PG were studied. Maximum removal efficiency was obtained at pH = 6.8, [ZnO]0 = 0.8 g L-1, and [PG]0 = 5 mg L-1 and reaction time of 150 min. The addition of persulfate sodium (PPS) enhanced the efficiency of the photocatalytic reaction. The efficiency of photolysis process in the presence of PPS was significantly improved to 72.72% compared to the classical photocatalysis system (56.71%). Optimum concentration of PPS to completely degraded PG was found to be 500 mg L-1. The QuEChERS extraction, GC-MS/MS method, and concentration technique showed favorable performance identification of the possible mechanism of PG degradation pathway. Toxicity of PG and its by-products were evaluated using microbioassays assessment based on nine selected bacterial strains. Results confirmed the effectiveness of the implemented system and its safe use via the bacteria Bacillus subtilis, which has illustrated significant activity. Due to the high efficiency, facility benefits, and low-cost of the suggested process, the process can be considered for the degradation of various pharmaceutical contaminants in pharmaceutical industry treatment under the optimal conditions.Waste furniture boards (WFBs) contain hazardous formaldehyde and volatile organic compounds when left unmanaged or improperly disposed through landfilling and open burning. In this study, pyrolysis was examined as a disposal and recovery approach to convert three types of WFBs (i.e., particleboard, plywood, and fiberboard) into value-added chemicals using thermogravimetric analysis coupled with Fourier-transform infrared spectrometry (TG-FTIR) and pyrolysis coupled with gas chromatography/mass spectrometry (Py-GC/MS). TG-FTIR analysis shows that pyrolysis performed at an optimum temperature of 250-550 °C produced volatile products mainly consisting of carbon dioxide, carbon monoxide, and light hydrocarbons, such as methane. Py-GC/MS shows that pyrolysis at different final temperatures and heating rates recovered mainly phenols (25.9-54.7%) for potential use as additives in gasoline, colorants, and food. The calorific value of WFBs ranged from 16 to 18 MJ/kg but the WFBs showed high H/C (1.7-1.8) and O/C (0.8-1.0) ratios that provide low chemical energy during combustion. This result indicates that WFBs are not recommended to be burned directly as fuel, however, they can be pyrolyzed and converted into solid pyrolytic products such as biochar with improved properties for fuel application. Hazardous components, such as cyclopropylmethanol, were removed and converted into value-added compounds, such as 1,43,6-dianhydro-d-glucopyranose, for use in pharmaceuticals. These results show that the pyrolysis of WFBs at high temperature and low heating rate is a promising feature to produce value-added chemicals and reduce the formation of harmful chemical species. Thus, the release of hazardous formaldehyde and greenhouse gases into the environment is redirected.Water and soil contamination due to potentially toxic elements (PTEs) represents a critical threat to the global ecosystem and human health. Naturally abundant resources have significant advantages as adsorbent materials for environmental remediation over manufactured materials such as nanostructured materials and activated carbons. These advantages include cost-effectiveness, eco-friendliness, sustainability, and nontoxicity. In this review, we firstly compare the characteristics of representative adsorbent materials including bentonite, zeolite, biochar, biomass, and effective modification methods that are frequently used to enhance their adsorption capacity and kinetics. Following this, the adsorption pathways and sites are outlined at an atomic level, and an in-depth understanding of the structure-property relationships are provided based on surface functional groups. Finally, the challenges and perspectives of some emerging naturally abundant resources such as lignite are examined. Although both unamended and modified naturally abundant resources face challenges associated with their adsorption performance, cost performance, energy consumption, and secondary pollution, these can be tackled by using advanced techniques such as tailored modification, formulated mixing and reorganization of these materials. Recent studies on adsorbent materials provide a strong foundation for the remediation of PTEs in soil and water. We speculate that the pursuit of effective modification strategies will generate remediation processes of PTEs better suited to a wider variety of practical application conditions.Limited knowledge of the combined effects of water and sediment properties and metal ionic characteristics on the solid-liquid partitioning of heavy metals constrains the effective management of urban waterways. This study investigated the synergistic influence of key water, sediment and ionic properties on the adsorption-desorption behavior of weakly-bound heavy metals. Field study results indicated that clay minerals are unlikely to adsorb heavy metals in the weakly-bound fraction of sediments (e.g., r = -0.37, kaolinite vs. Cd), whilst dissociation of metal-phosphates can increase metal solubility (e.g., r = 0.61, dissolved phosphorus vs. Zn). High salinity favors solubility of weakly-bound metals due to cation exchange (e.g., r = 0.60, conductivity vs. Cr). Dissolved organic matter does not favor metal solubility (e.g., r = -0.002, DOC vs. Pb) due to salt-induced flocculation. Laboratory study revealed that water pH and salinity dictate metal partitioning due to ionic properties of Ca2+ and H+. Selectivity for particulate phase increased in the order Cu>Pb>Ni>Zn, generally following the softness (2.89, 3.58, 2.82, 2.34, respectively) of the metal ions. Desorption followed the order Ni>Zn>Pb>Cu, which was attributed to decreased hydrolysis constant (pK1 = 9.4, 9.6, 7.8, 7.5, respectively). The study outcomes provide fundamental knowledge for understanding the mobility and potential ecotoxicological impacts of heavy metals in aquatic ecosystems.Cartap is a carbamate insecticide intended to protect crops such as rice, tea, and sugarcane. learn more Cartap in the environment presents a serious threat to non-target organisms through direct exposure or via biomagnification. Electro-assisted Fenton technology taps the potential of Fenton reagents to degrade cartap. Electrochemical reduction of iron accelerates catalyst regeneration. Cartap degradation was first investigated by varying reaction pH, as well as the initial H2O2 and Fe2+ dosage, followed by optimization studies using central composite design. Parametric results indicate the highest cartap removal of 98.10% was achieved at 1.6 pH, 3.0 mM Fe2+, and 40 mM H2O2 at I = 1.0 A and t = 30 min. These results notoriously surpass conventional Fenton that only achieved 53.8% cartap removal under similar conditions. The hybridization of Fenton process through electrochemical regeneration enhances removal and increases degradation kinetic up to a pseudo-first-order rate constant value of 21.30 × 10-4 s-1. Effects of coexisting inorganic salts PO43-, NO3-, and Cl- at 1 mM and 10 mM concentrations were investigated. These results demonstrate that Fenton electrification as process intensification alternative can enhance the performance and competitiveness of conventional Fenton by ensuring higher availability of iron catalyst while minimizing sludge production.The synthesis of Bi2WO6 and CeO2 photocatalytic nanomaterials exhibit a great ability to photodegrade the antibiotics and shown excellent oxidation of various organic pollutants. Heterostructure 11 & 21 Bi2WO6/CeO2 nanocomposite was successfully synthesized via the facile sono-dispersion method and exquisite photocatalytic activity. The 0.5 wt% of nanocomposites were well-grafted on PVDF membrane surface via an in-situ polymerization method using polyacrylic acid. The fourier transform infrared (FTIR) spectra demonstrated that the network formation in PVDF induced by the -COOH functional group in acrylic acid. The grafted membrane morphology and strong binding ability over the membranes were validated by scanning electron microscope with energy dispersion (SEM-EDS) and X-ray photoelectron spectroscopy (XPS), respectively. The permeate flux of 49.2 L.m-2 h-1 and 41.65 L.m-2 h were observed for tetracycline and the humic acid solution respectively for 1 wt% of PVP and 0.5 wt% of photocatalytic nanomaterials in PVDF membrane.