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After IPTW, Cox proportional hazard regression demonstrated that both the RIT and RI groups had higher survival rates than the BR group.

In HCC patients, surgery was associated with higher survival rates compared with radiotherapy while adjusting for other factors. Among those who received radiotherapy, RIT and RI granted survival benefits.

In HCC patients, surgery was associated with higher survival rates compared with radiotherapy while adjusting for other factors. Among those who received radiotherapy, RIT and RI granted survival benefits.

Platelet count (PLT) has been proved as an essential biomarker for the survival of hepatocellular carcinoma (HCC). However, the prognostic value of PLT change (ΔPLT) is still uncertain. The aim of this study was to explore the relationship between ΔPLT and HCC survival after transarterial chemoembolization (TACE) treatment.

Cox proportional hazard regression models were used to calculate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for HCC. The non-linear relationship between ΔPLT and OS was estimated through a restricted cubic spline regression analysis, and a two-piece-wise Cox proportional hazard model was further performed to calculate the threshold effect.

A total of 597 HCC patients treated with TACE were selected for the secondary analysis. Compared with the ΔPLT within ±20 (×10

/L), ΔPLT≥20 (×10

/L) was significantly associated with an 64% increase in risk of death (HR, 1.64; 95% CI 1.21 to 2.22) after adjustment for confounding variables, but the association was not significant in the group of ΔPLT≤-20 (HR, 1.23; 95% CI 0.92 to 1.63). We also found a U-shape relationship between ΔPLT and HCC survival at the turning point of ΔPLT as 0 (20×10

/L). The HR for the death was 1.12 (95% CI 1.06, 1.18) with ΔPLT≥0 (20×10

/L) while 0.95 (95% CI 0.92, 0.98) with ΔPLT<0 (20×10

/L). After potential confounding factors were adjusted, the non-linear relationship between ΔPLT and OS was still significant (

=0.013). Besides, ΔPLT≥20 (×10

/L) was associated with new lesions (OR, 2.74; 95% CI 1.38 to 5.45).

Elevated PLT was associated with poor overall survival of HCC patients after TACE treatment.

Elevated PLT was associated with poor overall survival of HCC patients after TACE treatment.

To evaluate the potential of drug-eluting bead (DEB)-transcatheter arterial chemoembolization (TACE) as a treatment option for patients with refractory to conventional lipiodol-based TACE (c-TACE) especially with decreased liver function.

We retrospectively evaluated the treatment results of DEB-TACE for 89 HCC nodules in 27 patients with c-TACE refractory according to liver function.

Although overall survival was significantly better in Child-Pugh A patients than in Child-Pugh B patients (median survival time, MST 561 vs 347 days,

=0.031), progression-free survival was almost similar in both patients between Child-Pugh A and B (MST 79 vs 87 days,

=0.534). Regarding antitumor response, the objective response rate (ORR) and disease-control rate (DCR) were 5.3/12.5% and 52.7/87.5% in Child-Pugh A/B, respectively. In each 89 HCC nodules, ORR and DCR were almost similar between Child-Pugh A and B (ORR, 20.3 vs 13.3%; DCR, 77.0 vs 73.3%, respectively). Adverse events of DEB-TACE were well-tolerated, and liver function was reserved during DEB-TACE procedures.

DEB-TACE could be a therapeutic option for advanced HCC patients with c-TACE refractory and decreased liver function.

DEB-TACE could be a therapeutic option for advanced HCC patients with c-TACE refractory and decreased liver function.

To improve the understanding of hepatic carcinosarcoma (HCS) by analyzing radiological imaging data and clinicopathological features.

A retrospective analysis was performed on four patients with HCS confirmed immunohistochemically. The analysis included three males and one female, aged 29 to 64 years. Four patients underwent computed tomography (CT) scans, and one underwent magnetic resonance imaging (MRI) scans simultaneously.

Three patients had a history of hepatitis B, cirrhosis or fibrosis, and two patients had schistosomiasis. Deruxtecan in vivo Two cases tested positive for elevated serum carbohydrate antigen (CA) 19-9. The maximum diameters of the lesions ranged from 7.8 to 9.0cm. Pathologically, the carcinomatous and sarcomatous elements in two patients could not be classified, one of the patients had cholangiocellular carcinoma (CCC) and undifferentiated sarcoma, the other had hepatocellular carcinoma (HCC) and undifferentiated pleomorphic sarcoma (UPS). All tumors showed heterogeneous density/intensity, accompanperative chemoradiotherapy can improve the survival rate of patients.

To investigate the value of amide proton transfer (APT) imaging in predicting the histological grade of hepatocellular carcinoma (HCC), compared with diffusion kurtosis imaging (DKI).

A total of 88 patients with HCC were enrolled and divided into four groups (G1, G2, G3, and G4) based on histologic grades. Preoperative APT signal intensity (SI), mean diffusivity (MD), mean kurtosis (MK) of HCC were measured and compared. Those quantitative magnetic resonance imaging (qMRI) parameters were compared using an analysis of variance. The correlations between the qMRI parameters and the histological grades were determined using Spearman's rank analysis. In addition, the predictive performance for differentiating low- (G1 and G2) from high-grade (G3 and G4) HCC was evaluated using receiver operating characteristic (ROC) curve analysis.

Significant differences were found in APT SIs, MD, and MK among the four groups (

<0.05). Moderate to good relationships were found between the histologic grade of HCC and APT SI and MK (

=0.679,

<0.001 and

=0.539,

<0.001, respectively). The area under the ROC curves (AUCs) of APT SI, MK, and MD for differentiating low- from high-grade HCC were 0.890 (95%CI 0.805-0.947), 0.765 (95%CI 0.662-0.849) and 0.717 (95%CI 0.611-0.808), respectively. Comparison of ROC curves showed a significantly higher AUC of APT SI compared with those of the DKI-derived parameters (

<0.05).

The APT imaging may be more accurate than DKI for predicting the histological grade of HCC.

The APT imaging may be more accurate than DKI for predicting the histological grade of HCC.