Knoxforrest5600

Background Amplified cardiopulmonary recording (ACPR) is a unique music therapy intervention implementing recorded heartbeats with meaningful music. Although its clinical application has grown, there is limited research on the acceptability and usage by bereaved families. Objective The research objective was to understand the frequency recipients engaged with ACPR after their loved one died. Design A survey was undertaken with relatives of 191 adult patients who had participated in ACPR. Setting/Subjects Bereaved loved ones of adult oncology patients who received care at the Norton Cancer Institute in Louisville, Kentucky, USA. Results Out of the 191 participants, 73% of family members responded, 49% reported listening to their recording frequently, 31% listened to the recording at least once after receiving it, and 20% reported never listening. Conclusions ACPR appears to have moderate acceptability and usage among bereaved family members, especially when created in the context of ongoing music therapy treatment. We recommend that this process-based music therapy intervention be studied further and offered proactively.

Individual case reports describe trazodone overdose resulting in QTc prolongation and cardiac arrhythmias. The clinical effects and outcomes associated with trazodone exposures on a large-scale basis are less well known.

The primary objective was to characterize the severity of single substance trazodone exposures and identify any relationships that may exist between dose of trazodone and severity of exposure. The secondary objective was to describe these exposures from a demographic and clinical symptom standpoint.

A retrospective review of single-substance trazodone exposures reported to the National Poison Data System (NPDS) from 1 January 2000 to 31 December 2019 was performed. The primary objective was to characterize the severity of trazodone exposures and relationships between ingested dose and level of care required or medical outcome.

A total of 118,773 cases were included in the analysis of demographics and level of care required. A majority (59.5%) of cases did not require medical admissionhe infrequent need for healthcare facility admission and large proportion of cases that experienced no effects or only minor effects.Surface lipoproteins (SLPs) are peripherally attached to the outer leaflet of the outer membrane in many Gram-negative bacteria, playing significant roles in nutrient acquisition and immune evasion in the host. While the factors that are involved in the synthesis and delivery of SLPs in the inner membrane are well characterized, the molecular machinery required for the movement of SLPs to the surface are still not fully elucidated. In this study, we investigated the translocation of a SLP TbpB through a Slam1-dependent pathway. Using purified components, we developed an in vitro translocation assay where unfolded TbpB is transported through Slam1-containing proteoliposomes, confirming Slam1 as an outer membrane translocon. While looking to identify factors to increase translocation efficiency, we discovered the periplasmic chaperone Skp interacted with TbpB in the periplasm of Escherichia coli. The presence of Skp was found to increase the translocation efficiency of TbpB in the reconstituted translocation assays. A knockout of Skp in Neisseria meningitidis revealed that Skp is essential for functional translocation of TbpB to the bacterial surface. Taken together, we propose a pathway for surface destined lipoproteins, where Skp acts as a holdase for Slam-mediated TbpB translocation across the outer membrane.Background Alternative BMI metrics are superior to BMI z score (BMIz) in tracking obesity but have not been evaluated in patients with nonalcoholic fatty liver disease (NAFLD). Our objective was to evaluate whether BMI-adjusted z score (BMIaz) or BMI expressed as a percentage of the 95th percentile (%BMIp95) are better predictors of degree of alanine aminotransferase (ALT) elevation, a surrogate for NAFLD severity, compared with BMIz in patients with NAFLD. Methods A retrospective study of 776 subjects aged 2-18 years with BMIz > 1.0 followed in a NAFLD subspecialty clinic was conducted. Regression analysis was used to determine predictors of elevated ALT. Results There was no association between BMIz, BMIaz, or %BMIp95 and degree of ALT elevation using linear or logistic regression. Conclusion These results do not support the use of alternative BMI metrics for evaluating NAFLD severity. Future studies should investigate longitudinal assessments and correlation with histology.Amaranth is a synthetic red azo dye approved in several countries such as Canada, Australia and Brazil, but banned in the United States. There are few studies evaluating the exposure of the general population to this food colouring substance, in Brazil, specifically, there are virtually no data on its intake. This study aimed to estimate the Theoretical Maximum Daily Intake (TMDI) of the Brazilian population and to quantify Amaranth in foods that contribute the most to its consumption. Data on the presence of Amaranth were correlated with consumption data from National Household Budget Surveys carried out in 2008/2009 and 2017/2018, among people aged ten or older. The results show that the mean TMDI (mg/day) of Amaranth does not exceed the Acceptable Daily Intake (ADI) in any population group, it, however, may get as high as 66% of the ADI among teenagers. For the TMDI balanced by the prevalence of food consumption, that is, considering consumers only (eaters only, rather than the population mean), results show that the amounts can exceed the ADI in all population groups studied. The intake of Amaranth is higher among the younger population (adolescents) reaching up to three times the ADI in the worst-case scenario. The food groups which contribute the most to the intake of Amaranth, are 'juices/artificial juices/reconstituted powdered juice mixes' and 'soft drinks'. Laboratory tests of powdered fruit mixes and soft drinks sold in the city of Porto Alegre (Brazil) show that 17 out of 20 samples tested exceeded the limit set by Brazilian regulations (5 mg/100 mL in the final product). Results show that the intake of Amaranth by the different Brazilian populations may pose a health hazard to several population groups.

This study aimed to examine physiological, mechanical and perceptual loading in small-sided games using different relative playing areas with balanced and unbalanced player numbers.

Data were collected in twelve elite youth male soccer players and included heart rate and standard time-motion outputs using commercial GPS.

The data demonstrated higher cardiovascular, physical and perceptual demands with increasing pitch size (e.g. average HR was 88.7 vs. 86.7% HRmax with 8 vs. 2 high-intensity acceleration in medium vs. small pitch formats. The largest pitch format resulted in a greater accumulation of high-intensity distance (47 ± 30 m), higher peak velocity (25.2 ± 1.6 km.h-1) and a higher distance and frequency of accelerations (35 ± 9 m and 8 ± 3) compared with the smallest pitch (all p < 0.01). In unbalanced games, there was significantly greater average heart rate in the overloaded team (84.4 ± 4.9 vs. 80.4 ± 4.8% HRmax in 4 v. 6).

These data suggest that different game formats including numerical imbalance could be prescribed for squad management to target conditioning stimuli for specific players (e.g. to target a higher training load for players that do not get consistent match exposure).

These data suggest that different game formats including numerical imbalance could be prescribed for squad management to target conditioning stimuli for specific players (e.g. to target a higher training load for players that do not get consistent match exposure).Dietary intake plays a significant role in athletic performance and is influenced by several factors, including nutrition knowledge. Gaelic footballers are amateur athletes who conduct high-intensity, intermittent activity during training and competition, and have previously demonstrated insufficient dietary intake. This study aimed to examine nutrition knowledge in elite and non-elite Gaelic footballers. An online survey was distributed to competitive Gaelic footballers, examining nutrition knowledge using the Abridged Nutrition for Sport Knowledge Questionnaire. Total, general, and sport nutrition knowledge were compared between elite and non-elite athletes, and those who had and had not previously received nutrition education, using Mann-Whitney U-tests. A total of 190 participants (15.3% women) completed the survey. No differences between elite and non-elite athletes in nutrition knowledge were identified (p > 0.05). Athletes with previous nutrition education scored higher than those without previous nutrition education in total (54.0 ± 4.9% vs 46.8 ± 9.6%; p = 0.002) and sport (51.9 ± 12.5% vs 43.4 ± 11.8%; p = 0.005) nutrition knowledge. Findings suggest an importance of nutrition education at all levels of athletic competition to improve nutrition knowledge, which may empower athletes to make appropriate dietary decisions to support training and competition demands.

This study examined the association between fitness, fundamental movement skills (FMS) and perceived competence on technical skills in boys engaged in grassroots soccer. Methods Sixty boys (8-12 years of age, Mean ± SD = 10 ± 1 years) undertook assessment of FMS, perceived competence, physical fitness (15m sprint speed, standing long jump distance and seated 1kg medicine ball throw as a composite z-score) and technical skills (dribbling, passing and shooting as a composite z-score).

Multiple backwards linear regression was used to determine to amount of variance in technical skill explained by FMS, perceived competence and fitness. Results indicated a significant model (F 3,58= 42.04, P = .0001, Adj R2 = .680) which explained 68% of the variance in technical skills. Perceived competence (β=.316, P =.001), Total FMS (β=.140, P =.002), and chronological age (β=.863), P =.001) significantly contributed to the model.

This study demonstrates that better technical skills (passing, dribbling, shooting) in youth soccer are explained, alongside age, by being competent in FMS and having a more positive perception of competence. Coaches should therefore seek to encourage development of these factors during childhood for the benefit of technical skill performance.

This study demonstrates that better technical skills (passing, dribbling, shooting) in youth soccer are explained, alongside age, by being competent in FMS and having a more positive perception of competence. Coaches should therefore seek to encourage development of these factors during childhood for the benefit of technical skill performance.

To investigate the injury characteristics in Finnish male football players.

One-season prospective epidemiological study. Data were collected via injury reports from the medical staff and directly from the players using the Olso Sports Trauma Research Center Health Questionnaire.

The first team squads of Finnish football league (n=12 teams, 236 players).

Injury incidence.

A total of 541 injuries occurred during the exposure of 62 878hours. Injury incidence per 1000 exposure hours was 8.6 (30.6 in matches and 3.4 in training). A player sustained on average 2.3 (median 2, range 0-13) injuries during the study. Thigh and ankle were the most commonly injured body parts for acute injuries and hip/groin were the most commonly injured body part for overuse injuries. The median absence time for all injuries was 12 (range 0-107) days, 12 (range 0-107) for acute, and 8 (range 0-61) for overuse injuries. Thigh injuries caused the greatest consequences in terms of absence from full participation (median 5days, range 0-88).