Klitpeele6188

arments and headscarves) and vitamin D deficiency (OR) = 8.0 95% CI (1.0 -64.1). Considering the correlation with the above-mentioned issues related to vitamin D deficiency, special attention should be paid to different factors contributing to vitamin D deficiency/ insufficiency in menopausal women, such as the degree of exposure to the sun and various aspects related to it, evaluation and prevention of vitamin D deficiency prevalence.The purpose of the research is to study therapeutic efficiency of medical rehabilitation of patients with Post-COVID-19 syndrome at outpatient treatment stage including natural therapeutic factors and phyto products in rehabilitation programme. In Nalchik resort 64 patients suffering from corona virus disease COVID-19 have been examined. They were distributed into 2 groups. 30 patients of the group of comparison were prescribed mineral water «Nalchik», exercise therapy, foam cocktails and rectal suppositories with thick licorice root extract. 34 patients of the main group additionally had natural aeroionophyto therapy along the route of mid-mountain natural park of Nalchik resort in combination with exercise therapy and group psychotherapy in park curative grounds and nitrogen thermal baths. The effectiveness was assessed with the help of the scale «Medical Research Council» (mMRC), the level of glycyrrhic acid in blood serum, functional tests, cardiointervalography in dynamics. The conducted comparative analysis proved the ability of natural therapeutic factors to influence the main life-supporting body systems positively. Therefore, the patients of the main group had a reduction of apnea by 29,4% (p less then 0,01) in comparison with the primary data, increase in adaptation capacity, on average, by 42,4% (p less then 0,01), improvement of physical activity, on average, by 36,2% (p less then 0,01), normalization of hemodynamic parameters. It was significantly better (by 20-25%, p less then 0,05) compared to the treatment in the group of comparison. There has been developed a new method of medical rehabilitation of patients with Post-COVID-19 syndrome at outpatient treatment stage including phytotherapy with licorice root extract and natural aeroionophyto therapy, exercise therapy, psychotherapy along the route of mid-mountain natural park in Nalchik resort, which significantly promotes (p less then 0,05) optimization of rehabilitation activities.Western countries have been challenged with an "allergy epidemic" during the last three to four decades. Interestingly, there has been a parallel increase in the incidence rates of several autoimmune disorders.The aim of our study was to evaluate antinuclear antibodies (ANA) in Georgian allergic patientspolysensitized with cross reactive allergens, in order to establish connection between allergic and autoimmune diseases in our population. Two groups of patients were included in the study patients with atopy (group 1, n=97) and without (group 2, n=42).ImmunoCAPPhadiatop and ISAC assay platforms were used for atopy screening and polysensitization patterns evaluation. Screening for ANAs was performed by IIFA (Indirect Immunofluorescence assay) on HEp-2 cells. In general 67(69.1%) allergic patients were sensitized to at least one of the cross reactive allergen. Among allergic patients 26 (26.8%) tested positive for the presence of auto-antibodies; for non-allergic patient this value was only 1(2.4%). 18(26.9%) patients sensitized to cross reactive allergens showed positive results for ANA testing and 8(26.7%) allergic patient without cross allergen sensitization were positive for ANA. The AC-2 was only one detected pattern among non-atopic individuals (1/2.4%) and the most frequent pattern in allergic patients (19/73%). In the ANA positive group of allergic patients the atopic dermatitis (13/50%) and asthma (6/23.1%) were most frequently diagnosed. The occurrence of antinuclear antibodies is more frequent in atopic patients and associate mostly with asthma and atopic dermatitis phenotypes of allergic diseases. The most frequent coexisting ANA pattern is dense fine speckled pattern (AC-2).The occurrence of ANA antibody in atopic patients and its role in allergy remains the subject for future research.In this clinical study, the effect of serological status of rheumatoid arthritis (RA) on the possibility and timing of clinical remission while taking the main non-biological disease modifying anti-rheumatic drugs (DMARD) was analyzed. The relationship between presence and levels of antibodies to cyclic citrullinated peptide (ACCP) and/or rheumatoid factor (RF) and remission in RA has also been studied. It was found that the frequency of remission, including early one (during the first 6 months of treatment), is three times higher in ACCP negative patients with RA. The rate of remission (ratio of early to total remission) does not depend on the serological status about two thirds of patients in all analyzed groups achieve remission in the first 6 months of DMARD therapy. ACCP and RF titers in the onset of the disease do not influence the possibility of remission achievement.The aim of the work was to study the effect of IL1Β (C3954T, rs1143634), PON1 (C108T, rs705379) gene variants on the risk of bacterial osteomyelitis development and its complicated course. The study involved 56 patients with osteomyelitis - 20 with not complicated (non-recurrent) course after treatment and 36 with complicated (recurrent) course. The data of population frequencies for the European population, obtained from the open database of "1000 Genomes project", were used as a control group. There was significantly increased distribution frequency of genotype 3954TT of IL1Β in patients with uncomplicated course compared to the control group (χ2=6.05, p=0.014, OR=4.99 (1.55-16.07)). And was found increased of minor genotype 108TT of PON1 frequency in patients with osteomyelitis compared to control group (χ2=4.38, p=0.036, OR=1.85(1.03-3.33)). JAK/stat pathway There were found gender differences in the clinical effects of IL1Β gene variant in men, the prevalence of genotype 3954CC was significantly to be increased in the patient with complicated osteomyelitis; genotype 3954CT was associated with a reduced risk of osteomyelitis and its complications developing, while in women was found the association of genotype 3954TT with an uncomplicated course of the disease. In conclusion, this study suggests that the variants of IL1В and PON1 genes associated with the risk of developing bacterial osteomyelitis and its complicated course and can be used as a prognostic marker for developing personalized prevention strategies.Aim of the study - to evaluate the impact of increased adherence to glycemic control on the improvement of quality of life and the course of ischemic heart disease (IHD) in patients with diabetes. The study includes 44 patients (26 males -59%, 18 females - 41%), diagnosed with IHD (functional class І-ІІІ of exertion angina) and accompanying type 2 DM. Depending on the glycaemia control method, the patients were divided in two groups. In group I (CGM, n=21) the glycaemia control was based on CGM, when in group II (self-blood glucose monitoring - SBGM, n=23) it was based on individual glucose level self-measurement, performed 4 times per day. Distribution of patients between groups I and II by gender, age, anthropometric characteristics, DM duration, functional heart and kidney condition, acute cardio-vascular events in anamnesis and harmful habits (smoking) is without significant differences. Besides glycaemia monitoring, the patients recorded their arterial pressure, pulse and duration of their physical exertions (minutes a day). During patients' elective visits (0-3 months) glycated hemoglobin was measured in both patient groups, and they filled in the life quality questionnaire. The use of CGM for monitoring glycaemia level in patients with IHD and type II DM during 3 months has been associated with statistically significant decrease of glycated hemoglobin level, increase of physical activity. Also CGM improved physical condition and life quality according to the physical health scores SF-36 (physical function, physical function role, physical pain, general health) and social function scores, with reliable increase in group I compared to group II. There are no differences in body weight decrease or improved carbohydrate metabolic data have been detected. Administration of the CGM in patients with IHD is associated with improved quality of life and higher satisfaction level, decreased fasting HbA1c and glucose, and also increasing level of physical exertion level.The aim of the study is to determine the effectiveness of the hypoxic training on microcirculation and the duration of preservation of the therapeutic effect in elderly patients with chronic obstructive pulmonary disease. 47 patients with COPD at the age of 60-74 years were examined. All examined patients with COPD were divided into two groups the main group (29 people), which received real hypoxic training, and the control group (18 people), which received simulated training. The state of cutaneous microcirculation and endothelial function were evaluated using a sample with reactive hyperemia. The studies were performed in the initial state (before training), immediately after, one month and three months after the course application of training. Due to hypoxic training in elderly patients with COPD, microcirculation and endothelial function improved, which persisted for a month. A correlation was established between increased blood saturation and improved microcirculation and endothelial function both immediately and a month after the application of hypoxic training in elderly patients with COPD. The state of microcirculation and endothelial function in patients with COPD did not depend on their resistance to hypoxia. But resistance to hypoxia determined the effectiveness of the effects of hypoxic training. In patients with reduced resistance to hypoxia, the therapeutic effect of hypoxic training was less significant and short-lived compared.The liver plays an important role in the development of atherogenic dyslipidemia, since changes in lipid metabolism begin at the hepatocyte level. Given the prevalence of dyslipidemias and their proven effect on the development of thrombotic cardiovascular complications in patients with non-alcoholic fatty liver disease (NAFLD), it is important to understand the role of platelets and hemostatic blood activity. Objective - to determine the state of platelet-plasma hemostasis in patients with essential hypertension, with concomitant non-alcoholic fatty liver disease. 152 patients were examined 72 men and 80 women. Three groups were identified I - 46 patients with hypertension stage II, II - 54 patients with NAFLD without hypertension, Group III - 52 patients with hypertension stage II with concomitant NAFLD. The total amount of spontaneous and induced platelet aggregation ability, coagulation activity, anticoagulant and fibrinolytic potential of blood was studied. The degree of spontaneous aggregation was signiolemia, spontaneous aggregation was 17.1% (p less then 0.05) less than in patients who did not receive statins and had high cholesterol levels, and the degree of collagen-induced aggregation decreased by 33.7% (p less then 0.05). In the subgroup with hypercholesterolemia, statins contributed to an increase in PTT by 32.5% (p less then 0.05), INR by 25.4% (p less then 0.05), and thrombin time - by 23.2% (p less then 0.05) and increased the activity of the anticoagulant link of hemostasis - the level of AT III increased by 3.1% (p less then 0.05) Hypercholesterolemia is associated with a higher functional activity of platelets, hyperfibrinogenemia. Statin therapy in patients with HT stage. and NAFLD is accompanied by a decrease in the activity of spontaneous aggregation, the coagulation link and increases the anticoagulant potential of the blood.