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ain intensity and paresthesia after implant surgery.

Peri-implantitis is an infectious disease that affects the tissues around dental implants, with clinical signs of inflammation and irreversible loss of supporting bone. This study aimed to compare the effect of sterile topical tetracycline ophthalmic ointment as an adjuvant to mechanical debridement with mechanical debridement alone in the treatment of peri-implantitis.

In this single-blind randomized clinical trial, 32 patients (16 patients in each group) with peri-implantitis were treated topically using sterile tetracycline ophthalmic ointment. Four clinical parameters, including modified bleeding index (mBI), modified plaque index (mPI), probing depth (PD), and clinical attachment level (CAL), were measured at baseline and at 3- and 6-month follow-up intervals.

PD reduction was statistically significant after 3 and 6 months in the test and control groups (

=0.001). Also, mPI and mBI reduction rates were significant in the test and control groups (

=0.001) after 3 and 6 months. However, in all the samples in the two groups, the mean of CAL before and after treatment was constant, with no significant difference (

>0.05).

Using sterile ocular tetracycline ointment could be an adjunctive treatment in improving and enhancing the therapeutic effects of mechanical debridement in the treatment of peri-implantitis. (IRCT20210909052418N1).

Using sterile ocular tetracycline ointment could be an adjunctive treatment in improving and enhancing the therapeutic effects of mechanical debridement in the treatment of peri-implantitis. (IRCT20210909052418N1).Periodontitis can lead to the loss of hard and soft tissues of the oral cavity. Dental implants have become a reliable treatment modality in recent times, especially with the evolution of digital technology such as CBCT, implant planning software, computer-assisted manufacturing, and guided implant surgery. Documentation of such advancements and their clinical implications would add to the existing knowledge on implant dentistry, encouraging dentists to approach complex implant surgeries confidently. This paper discusses the rehabilitation of missing teeth by applying computer-assisted guided implant placement in two cases with deficient bone volume anteriorly and posteriorly in the maxilla, respectively. Digital planning and careful execution have resulted in precise implant placement and complete osseointegration. In these cases, we could devise treatment plans with both anatomical and prosthetic considerations while being minimally invasive and more predictable, with shorter treatment time and greater patient comfort.Chloroform is used widely in endodontic treatments for solving gutta-percha points, but it can have destructive effects if it comes in to contact with oral mucosa. This article presents a case of necrotic ulcer of palatal and buccal mucosa due to injudicious use of chloroform in endodontic treatment, which has caused severe destruction in maxilla. A conservative treatment method of repeated curettage and irrigation was used and although the lesion healed completely, it had major effects on the patient's quality of life including loss of two teeth. It is important that dentist be aware of the devastating effects of imprudent application of various chemicals used in dentistry. The conservative treatment used for this case can be helpful option for similar cases.

The current study tested netrin-1 as a reliable inflammatory marker of periodontal disease.

Gingival crevicular fluid (GCF) samples were taken at baseline from 30 systemically healthy individuals. Fifteen subjects had stage II grade A or B periodontitis, and 15 were periodontally and clinically healthy. Whole-mouth periodontal parameters [probing depth (PD), clinical attachment loss (CAL), plaque index (PI), and gingival index (GI)] were recorded. The GCF samples were re-collected, and clinical parameters were re-recorded after six weeks following full-mouth scaling and root planing (SRP) in the periodontitis group.

Netrin-1 GCF levels were significantly lower in periodontitis patients than periodontally healthy individuals at baseline with a significant increase in netrin-1 GCF levels after SRP (

<0.05).

Netrin-1 may have a significant role in the inflammatory process of chronic periodontitis; thus, it could be a promising anti-inflammatory marker in periodontal disease.

Netrin-1 may have a significant role in the inflammatory process of chronic periodontitis; thus, it could be a promising anti-inflammatory marker in periodontal disease.

This clinical trial evaluated the effect of coenzyme Q10 supplementation along with scaling and root planing (SRP) on periodontal and gingival indices in controlled diabetic patients.

Forty-two diabetic patients (controlled type), referred to the Department of Periodontics with chronic periodontitis and eligible for the study, were included in the study. Patients suffering from chronic periodontitis with a probing pocket depth of ≥5 mm in different quadrants of the oral cavity with radiographic evidence of bone loss were included in the present randomized, double-masked, placebo-controlled clinical trial. https://www.selleckchem.com/products/pdd00017273.html The subjects were instructed to take one capsule of coenzyme Q10 or a placebo every day for 30 days following SRP. Clinical parameters, i.e., plaque index (PI), gingival index (GI), bleeding on probing (BOP), clinical attachment level (CAL), and probing pocket depth (PPD), were recorded at baseline and four weeks after treatment by two masked and calibrated examiners. The study results were reported as (mean ± standard deviations) and frequencies (percentages).

One month after the intervention, PPD, CAL, BOP, and PI indices in the intervention group were significantly lower than those in the control group. One month after the intervention, the GI was similar in both groups. A significant decrease was observed in the GI in both groups after the intervention.

The results of the present study showed that Q10 orally with scaling and root planing in patients with controlled diabetes with chronic periodontitis might accelerate the treatment process and significantly reduce the pocket depth.

The results of the present study showed that Q10 orally with scaling and root planing in patients with controlled diabetes with chronic periodontitis might accelerate the treatment process and significantly reduce the pocket depth.Multimetallic-multielectron cooperativity plays a key role in the metal-mediated cleavage of N2 to nitrides (N3-). In particular, low-valent uranium complexes coupled with strong alkali metal reducing agents can lead to N2 cleavage, but often, it is ambiguous how many electrons are transferred from the uranium centers to cleave N2. Herein, we designed new dinuclear uranium nitride complexes presenting a combination of electronically diverse ancillary ligands to promote the multielectron transformation of N2. Two heteroleptic diuranium nitride complexes, [KUIV(OSi(O t Bu)3)(N(SiMe3)2)22(μ-N)] (1) and [CsUIV(OSi(O t Bu)3)2(N(SiMe3)2)2(μ-N)] (3-Cs), containing different combinations of OSi(O t Bu)3 and N(SiMe3)2 ancillary ligands, were synthesized. We found that both complexes could be reduced to their U(iii)/U(iv) analogues, and the complex, [K2UIV/III(OSi(O t Bu)3)2(N(SiMe3)2)2(μ-N)] (6-K), could be further reduced to a putative U(iii)/U(iii) species that is capable of promoting the 4e- reduction of N2, yielding the N2 4-complex [K3UV(OSi(O t Bu)3)2(N(SiMe3)2)2(μ-N)(μ-η2η2-N2)], 7. Parallel N2 reduction pathways were also identified, leading to the isolation of N2 cleavage products, [K3UVI(OSi(O t Bu)3)2(N(SiMe3)2)([triple bond, length as m-dash]N)(μ-N)2UV(OSi(O t Bu)3)2(N(SiMe3)2)]2, 8, and [K4(OSi(O t Bu)3)2UV)([triple bond, length as m-dash]N)(μ-NH)(μ-κ2C,N-CH2SiMe2NSiMe3)-UV(OSi(O t Bu)3)2][K(N(SiMe3)2]2, 9. These complexes provide the first example of N2 cleavage to nitride by a uranium complex in the absence of reducing alkali metals.A solvent-free route based on solid raw materials affords higher product yield and lower waste production compared to the traditional hydrothermal synthesis. However, the as-made zeolites usually present blocky aggregation states, limiting their mass transfer and exposure of active sites in catalytic applications. Herein, highly dispersed nanosized hierarchical Beta zeolites with varied Si/Al ratios were prepared via steam-assisted crystallization from ball-milled solid raw materials. Thanks to the sufficient mixing of solid raw materials and favorable migration of solid mixture, nanosized Beta zeolites are obtained that are assembled from nanoparticles (∼15 nm) and possess abundant interconnected intraparticle mesopores. The strategy can also be extended to synthesize nanosized hierarchical ZSM-5 zeolites. The as-prepared Beta zeolite (Si/Al = 10) exhibits outstanding catalytic performance in conversion of lactic acid to lactide (as high as 77.5% in yield). This work provides avenues for simple and cost-efficient synthesis of highly dispersed nanosized hierarchical zeolites, promising their important catalytic applications.Highly reactive organometallic nanoclusters in situ generated in metal-catalyzed reactions are pivotal in the comprehension of catalytic mechanisms. Herein, we develop a two-step synthetic method to achieve three unprecedented aryl dicarbanion-bonded Ag13 nanoclusters by using protective macrocyclic ligands. Firstly, various aryl dicarbanion-Ag4 cluster intermediates are acquired via a silver-mediated annulation reaction within a macrocyclic ligand. These Ag4 cluster precursors are released from the surrounding macrocycle by protonation, and further undergo an inter-cluster coupling to generate bipyridine products and low-valence silver atoms. The remaining resurgent diide-Ag4 clusters assemble with low-valence silver atoms to yield a series of organometallic Ag13 nanoclusters. These Ag13 nanoclusters feature a unique open-shell electronic structure as well as a chiral cluster architecture due to the asymmetric arrangements of surrounding aryl dianion ligands. Furthermore, the pyridyl diide ligands on the surface of the nanocluster further experience an intra-cluster oxidative coupling to produce bipyridine coupling products and large nanoparticles. The coupling reaction-driven cluster-to-cluster transformation is comprehensively tracked by high resolution mass spectroscopy. This work is not only reminiscent of the detailed evolution of cluster species upon the occurrence of coupling reactions, but also reproduces novel inter- and intra-cluster coupling steps at different reaction stages.In the electrochemical CO2 reduction reaction (CO2RR), halide ions could impose a significant effect on multi-carbon (C2+) product production for Cu-based catalysts by a combined contribution from various mechanisms. However, the nature of specific adsorption of halide ions remains elusive due to the difficulty in decoupling different effects. This paper describes a facile method to actively immobilize the morphology of Cu-based catalysts during the CO2RR, which makes it possible to reveal the fundamental mechanism of specific adsorption of halide ions. A stable morphology is obtained by pre-reduction in aqueous KX (X = Cl, Br, I) electrolytes followed by conducting the CO2RR using non-buffered and non-specifically adsorbed K2SO4 as the supporting electrolyte, by which the change of local pH and cation concentration is also maintained during the CO2RR. In situ spectroscopy revealed that the specific adsorption of halide ions enhances the adsorption of *CO intermediates, which enables a high selectivity of 84.