Kirkismail0624

In 2017-2018, a group of international development funding agencies launched the Crops to End Hunger initiative to modernize public plant breeding in lower-income countries. To inform that initiative, USAID asked the International Food Policy Research Institute and the United States Department of Agriculture's Economic Research Service to estimate the impacts of faster productivity growth for 20 food crops on income and other indicators in 106 countries in developing regions in 2030. We first estimated the value of production in 2015 for each crop using data from FAO. We then used the IMPACT and GLOBE economic models to estimate changes in the value of production and changes in economy-wide income under scenarios of faster crop productivity growth, assuming that increased investment will raise annual rates of yield growth by 25% above baseline growth rates over the period 2015-2030. We found that faster productivity growth in rice, wheat and maize increased economy-wide income in the selected countries in 2030 by 59 billion USD, 27 billion USD and 21 billion USD respectively, followed by banana and yams with increases of 9 billion USD each. While these amounts represent small shares of total GDP, they are 2-15 times current public R&D spending on food crops in developing countries. Income increased most in South Asia and Sub-Saharan Africa. Zimlovisertib Faster productivity growth in rice and wheat reduced the population at risk of hunger by 11 million people and 6 million people respectively, followed by plantain and cassava with reductions of about 2 million people each. Changes in adequacy ratios were relatively large for carbohydrates (already in surplus) and relatively small for micronutrients. In general, we found that impacts of faster productivity growth vary widely across crops, regions and outcome indicators, highlighting the importance of identifying the potentially diverse objectives of different decision makers and recognizing possible tradeoffs between objectives.The quadrilateral anterior cervical plate (ACP) is used extensively in anterior cervical discectomy and fusion (ACDF) to reconstruct the stability of the cervical spine and prevent cage subsidence. However, there have been no comparison studies on the biomechanical performance of quadrilateral ACP and triangular ACP. The objective of this study is to investigate the functional outcomes of quadrilateral ACP and triangular ACP usage in ACDF surgery. In this study, a finite element model of intact C1-C7 segments was established and verified. Additionally, two implant systems were built; one using triangle anterior cervical plates (TACP) and another using quadrilateral orion anterior cervical plate (QACP). Both models were then compared in terms of their postoperative biomechanical performance, under normal and excessive motion. Compared to QACP, the peak stress of the TACP screws and plates occurred at 359.2 MPa and 97.2 MPa respectively and were the highest during over extension exercises. Alternately, compared to TACP, the endplate peak stress and the cage displacement of QACP were the largest at over extension, with values of 7.5 MPa and 1.2 mm, respectively. Finally, the average stress ratio of bone grafts in TACP was relatively high at 31.6%. In terms of biomechanical performance, TACP can share the load more flexibly and reduce the risks of cage subsidence and slippage but the screws have high peak stress value, thereby increasing the risk of screw slippage and fracture. This disadvantage must be considered when designing a TACP based implant for a potential patient.

We sought to identify plasma protein biomarkers that are predictive of the outcome of rescue cerclage in patients with cervical insufficiency.

This retrospective cohort study included 39 singleton pregnant women undergoing rescue cerclage for cervical insufficiency (17-25 weeks) who gave plasma samples. Three sets of pooled plasma samples from controls (cerclage success, n = 10) and cases (cerclage failure, n = 10, defined as spontaneous preterm delivery at <33 weeks) were labeled with 6-plex tandem mass tag (TMT) reagents and analyzed by liquid chromatography-tandem mass spectrometry. Differentially expressed proteins between the two groups were selected from the TMT-based quantitative analysis. Multiple reaction monitoring-mass spectrometry (MRM-MS) analysis was further used to verify the candidate proteins of interest in patients with cervical insufficiency in the final cohort (n = 39).

From MRM-MS analysis of the 40 proteins showing statistically significant changes (P < 0.05) from the TMT-basRM) that predict poor pregnancy outcome following rescue cerclage. Their combined analysis in a multi-biomarker panel significantly improved predictability.

Several serum inflammatory markers are associated with poor clinical outcomes in community-acquired pneumonia (CAP). However, the prognosis and early treatment response in hospitalized CAP patients based on serial neutrophil-to-lymphocyte ratio (NLR) measurement has never been investigated.

We performed a retrospective observational study for 175 consecutive patients hospitalized with CAP between February 2016 and February 2018. NLR, C-reactive protein (CRP) and procalcitonin levels were measured on admission day (D1) and on hospital day 4 (D4). The Pneumonia Severity Index (PSI) was also assessed on admission. The primary endpoint was all-cause death within 30 days after admission. The secondary endpoint was early treatment response such as intensive care unit (ICU) admission during hospitalization and clinical unstability on day 4.

The 30-day mortality rate was 9.7%. In multivariate analysis, NLR D4 (OR 1.11; 95% CI 1.04-1.18; P = 0.003) and its incremental change (NLR D4/D1 >1) (OR 7.10; 95% CI 2.19-23.06; P = 0.001) were significant predictors of 30-day mortality. NLR D4 and its incremental change were significant predictors of ICU admission and clinical unstability on day 4 in multivariate analyses. Adding of incremental NLR change significantly improved the prognostic ability of the PSI. The additive value of incremental NLR change for the prognostic ability of the PSI was larger than that of incremental CRP change.

Serial NLR measurement represents useful laboratory tool to predict the prognosis and early treatment response of hospitalized CAP patients.

Serial NLR measurement represents useful laboratory tool to predict the prognosis and early treatment response of hospitalized CAP patients.