Kirkegaardclemensen2969

COVID-19, a pandemic declared by WHO, has infected about 39.5 million and killed about 1.1 million people throughout the world. There is the urgent need of more studies to identify the novel drug targets and the drug candidates against it to handle the situation.

To virtually screen various drugs against SARS-CoV-2, the scientists need the detail information about the various drug targets identified till date. The present review provides the information about almost all the drug targets, including structural and non-structural proteins of virus as well as host cell surface receptors, that can be used for virtual screening of drugs. Moreover, this review also focuses on the different network analysis tools that have been used for the identification of new drug targets and candidate repurposable drugs against SARS-CoV-2.

This review provides important insights of various drug targets and the network analysis tools to young bioinformaticians and will help in creating pace to the drug repurposing strategy for COVID-19 disease.

This review provides important insights of various drug targets and the network analysis tools to young bioinformaticians and will help in creating pace to the drug repurposing strategy for COVID-19 disease.

There have been significant advancements in different aspects of management of severe acute pancreatitis (SAP). Our review of the most recent literature focuses on severity prediction, fluid resuscitation, analgesic administration, nutrition, and endoscopic intervention for SAP and its extra-pancreatic complications.

Recent studies on serum cytokines for the prediction of SAP have shown superior prognostic performance when compared with conventional laboratory tests and clinical scoring systems. In patients with established SAP and vascular leak syndrome, intravenous fluids should be administered with caution to prevent intra-abdominal hypertension and volume overload. Endoscopic retrograde cholangiopancreatography improves outcomes only in AP patients with suspected cholangitis. Early enteral tube-feeding does not appear to be superior to on-demand oral feeding. Abdominal compartment syndrome is a highly lethal complication of SAP that requires percutaneous drainage or decompressive laparotomy. Endoscopiep-up, minimally invasive drainage/debridement is the preferred approach for patients with infected pancreatic necrosis.

To provide an approach to the diagnosis and treatment of arrhythmias associated with inflammatory cardiomyopathies.

Inflammatory cardiomyopathies are increasingly recognized as the etiology of both ventricular and supraventricular arrhythmias. ARS853 There have been recent studies providing novel insights into the pathogenesis of arrhythmias in inflammatory cardiomyopathies and exploring the role of various diagnostic tools and treatment strategies.

Patients with inflammatory cardiomyopathies often present with one or more arrhythmias, including atrioventricular block, atrial and ventricular tachyarrhythmias, and occasionally sudden cardiac death. Given dynamic pathophysiology and heterogeneous presentation, the management of arrhythmias in these patients presents unique challenges. We review the current approach to the diagnosis and treatment of arrhythmias in this challenging cohort of patients with an emphasis on cardiac sarcoidosis.

The online version of this article (10.1007/s11936-020-00871-5) contains supplementary material, which is available to authorized users.

The online version of this article (10.1007/s11936-020-00871-5) contains supplementary material, which is available to authorized users.In the face of the global COVID-19 recession, countries are looking at stimulus packages to kick-start their stalled economies. The recovery from the COVID-19 crisis also coincides with a critical opportunity to fight against ecosystem degradation and climate change. In this opinion article, I put in perspective that by investing in ecological restoration, governments do not have to choose between economic priorities and environmental concerns. First, I describe the restoration economy and give real-world examples of how investing in restoration activities can simultaneously ease pressure on the environment and create immediate jobs and revenues. Then I suggest that to obtain political attraction, a successful restoration strategy will require a triple-bottom-line approach to ensure that in addition to environmental objectives, stakeholders integrate socioeconomic outcomes in decision-making. Finally, I conclude that a new economic approach that prioritizes investment in our ecological capital will necessitate transdisciplinary policies to build bridges across the different silos of the economy and the environment.Social exclusion is one of the most complex and sensitive social problems nowadays. Of all social groups, adolescents are among the most vulnerable to social exclusion, which can interfere with their social development. Consequently, the evaluation of this construct in adolescents is an important matter. The aim of this investigation was to develop the Social Inclusion for Adolescents Scale (SIAS). Firstly, five psychosocial factors were proposed, which potentially contribute to social inclusion (1) covered needs, (2) self-efficacy, (3) social support, (4) job training, and (5) social integration. From these five factors, a set of items was created and reduced using qualitative evaluations. The final set of items was used in three studies, with a Spanish population (N = 1540) and a foreign population (N = 460), to test the psychometric properties of the scale, its dimensional structure, the measurement invariance between Spanish and foreign people, the reliability of the instrument and the evidence of the validity of its measurements. The results indicate that this scale is psychometrically reliable enough to assess social inclusion in adolescents.

The online version contains supplementary material available at 10.1007/s12144-020-01201-5.

The online version contains supplementary material available at 10.1007/s12144-020-01201-5.The outbreak of COVID-19 leads to an increasing demand for online educational resources to continue teaching and learning. Open educational resources (OER), with the benefits of cost-saving and open licenses, have great potential in facilitating the rapid transition to digital education, but concerns about whether OER decrease the effectiveness of student learning remains unsolved. Hilton's review article (2016) provides synthesized evidence stating that OER can help decrease college students' textbook spending without undermining student learning effectiveness. It is also noteworthy that implementing OER in digital education needs additional considerations beyond the efficacy of OER. Therefore, this special issue article extends Hilton's (2016) synthesized findings by presenting four additional perspectives in research, design, culture, practice about implementing OER in digital education.