Kimmoss9116

Through the integration of results from an imaging analysis of intracellular trafficking of labelled neurosecretory vesicles in chromaffin cells, we develop a Markov state model to describe their transport and binding kinetics. Our simulation results indicate that a spatial redistribution of neurosecretory vesicles occurs upon secretagogue stimulation leading vesicles to the plasma membrane where they undergo fusion thereby releasing adrenaline and noradrenaline. Furthermore, we find that this redistribution alone can explain the observed up-regulation of vesicle transport upon stimulation and its directional bias towards the plasma membrane. Parameter fitting indicates that in the deeper compartment within the cell, vesicle transport is asymmetric and characterised by a bias towards the plasma membrane.Compelling evidence supports the current international recommendation of at least 150 min/week of leisure-time physical activity (LTPA) during pregnancy. However, the potential relationship between LTPA and birth weight (BW) remains unclear in low- and middle-income countries. The purpose of this study was to examine the association between LTPA during pregnancy and offspring BW in an Amazonian population. Prospective cohort study was carried-out with 500 pregnant women and their offspring followed-up in the MINA-Brazil study, which was conducted in Cruzeiro do Sul, Western Brazilian Amazon. LTPA was assessed in the second (mean 19.6, SD 2.4 weeks) and third (mean 27.8, SD 1.6 weeks) gestational trimesters by a standardised interview and categorised according to the recommended cut-off of at least 150 min/week. We calculated offspring BW z-scores by sex and gestational age. We then explored the effect of LTPA during pregnancy on offspring BW, the association between LTPA and small-for-gestational-age (SGA) or large-for-gestational-age (LGA) births, and the mediating role of excessive and insufficient gestational weight gain (GWG). At least 150 min/week of LTPA during the third gestational trimester was associated with an offspring BW decrease of -0.35 z-score (95% CI -0.65, -0.05) or -147.9 grams (95% CI -260.9, -14.8), without increasing the frequency of SGA foetuses either in the second or third gestational trimester (p > 0.05). Excessive GWG mediated the effect of LTPA on the offspring BW (indirect effect = -0.05 z-score [95% CI -0.10, -0.00] or -34.7 grams (95% CI -66.1, -3.3]). This mediation effect was not observed for insufficient GWG. LTPA in the third, but not in the second, trimester of pregnancy was inversely associated with offspring BW without increasing the frequency of SGA, an effect that was partly mediated by excessive GWG.Real-time communication, unlimited distribution of information, and the lack of editorial supervision in social media communication aggravate recipients' credibility evaluations and information selection by what aspects of the source such as expertise have emerged as important anchors for evaluations. It has long been assumed that credibility judgments in social media are specifically guided by heuristics. However, the existing studies merely give indications, for example, based on individuals' self-report but do not test whether important attributes and prerequisites of heuristic decision-making, such as effort reduction, are present. Against this background, the current study (N = 185) analyses by applying a reduced two-alternative choice paradigm whether the relation between the expertise cue and credibility judgments and the choice of information sources is guided by a heuristic, namely the expertise heuristic. Findings indicate that the presence of the expertise cue reduced respondents' task latencies significantly, although participants' decision behavior was not independent from additional information. Selleck P5091 This is discussed in detail with recourse to theoretical conceptualizations of cognitive heuristics.This study aimed to test two common explanations for the general finding of age-related changes in the performance of timing tasks within the millisecond-to-second range intervals. The first explanation is that older adults have a real difficulty in temporal processing as compared to younger adults. The second explanation is that older adults perform poorly on timing tasks because of their reduced cognitive control functions. These explanations have been mostly contrasted in explicit timing tasks that overtly require participants to process interval durations. Fewer studies have instead focused on implicit timing tasks, where no explicit instructions to process time are provided. Moreover, the investigation of both explicit and implicit timing in older adults has been restricted so far to healthy older participants. Here, a large sample (N = 85) comprising not only healthy but also pathological older adults completed explicit (time bisection) and implicit (foreperiod) timing tasks within a single session. Participants' age and cognitive decline, measured with the Mini-Mental State Examination (MMSE), were used as continuous variables to explain performance on explicit and implicit timing tasks. Results for the explicit timing task showed a flatter psychometric curve with increasing age or decreasing MMSE scores, pointing to a deficit at the level of cognitive control functions rather than of temporal processing. By contrast, for the implicit timing task, a decrease in the MMSE scores was associated with a reduced foreperiod effect, an index of implicit time processing. Overall, these findings extend previous studies on explicit and implicit timing in healthy aged samples by dissociating between age and cognitive decline (in the normal-to-pathological continuum) in older adults.Using the synthetic control method, we construct counterfactuals for what would have happened if Sweden had imposed a lockdown during the first wave of the COVID-19 epidemic. We consider eight different indicators, including a novel one that we construct by adjusting recorded daily COVID-19 deaths to account for weakly excess mortality. Correcting for data problems and re-optimizing the synthetic control for each indicator, we find that a lockdown would have had sizable effects within one week. The much longer delay estimated by two previous studies focusing on the number of positives cases is mainly driven by the extremely low testing frequency that prevailed in Sweden in the first months of the epidemic. This result appears relevant for choosing the timing of future lockdowns and highlights the importance of looking at several indicators to derive robust conclusions. We also find that our novel indicator is effective in correcting errors in the COVID-19 deaths series and that the quantitative effects of the lockdown are stronger than previously estimated.Measurements of human attitudes and perceptions have traditionally used numerical point judgments. In the present study, we compared conventional point estimates of weight with an interval judgment method. Participants were allowed to make step by step judgments, successively converging towards their best estimate. Participants estimated, in grams, the weight of differently sized boxes, estimates thus susceptible to the size-weight illusion. The illusion makes the smaller of two objects of the same weight, differing only in size, to be perceived as heavier. The self-selected interval method entails participants judging a highest and lowest reasonable value for the true weight. This is followed by a splitting procedure, consecutive choices of selecting the upper or lower half of the interval the individual estimates most likely to include the true value. Compared to point estimates, interval midpoints showed less variability and reduced the size-weight illusion, but only to a limited extent. Accuracy improvements from the interval method were limited, but the between participant variation suggests that the method has merit.Rubus idaeus L. (red raspberry), is a perennial woody plant species of the Rosaceae family that is widely cultivated in the temperate regions of world and is thus an economically important soft fruit species. It is prized for its flavour and aroma, as well as a high content of healthful compounds such as vitamins and antioxidants. Breeding programs exist globally for red raspberry, but variety development is a long and challenging process. Genomic and molecular tools for red raspberry are valuable resources for breeding. Here, a chromosome-length genome sequence assembly and related gene predictions for the red raspberry cultivar 'Anitra' are presented, comprising PacBio long read sequencing scaffolded using Hi-C sequence data. The assembled genome sequence totalled 291.7 Mbp, with 247.5 Mbp (84.8%) incorporated into seven sequencing scaffolds with an average length of 35.4 Mbp. A total of 39,448 protein-coding genes were predicted, 75% of which were functionally annotated. The seven chromosome scaffolds were anchored to a previously published genetic linkage map with a high degree of synteny and comparisons to genomes of closely related species within the Rosoideae revealed chromosome-scale rearrangements that have occurred over relatively short evolutionary periods. A chromosome-level genomic sequence of R. idaeus will be a valuable resource for the knowledge of its genome structure and function in red raspberry and will be a useful and important resource for researchers and plant breeders.

Post-partum family planning is a novel strategy to reduce maternal and neonatal mortality by preventing unwanted pregnancy and unsafe abortion. However, little was done on community-based design to assess modern contraceptive use during an extended postpartum period in southern Ethiopia. Therefore, this study aimed to assess modern contraceptive use during extended postpartum period and factors associated among women who gave birth in the previous twelve months in southern Ethiopia.

A community-based cross-sectional study was conducted among 416 women in Arba Minch town. A systematic random sampling technique was employed to select the enrolled women. Data were collected using a structured and pretested questionnaire. The data were entered into Epi-Data version 4.6 then exported to statically package of social science (SPSS) version 25 for data analysis.

Among enrolled postpartum women, 64.7% were used modern contraceptives for the last 12 months. Women were more likely to use a modern contraceptive durefore, in light of this finding, there is a need to improve the strengthening and scale-up antenatal and postnatal counseling of contraceptive use during the extended postpartum period, advice on preceding the return of menses, and give better attention for older age and unmarried women education on family planning.

One of the most prescribed treatments for benign prostatic hyperplasia (BPH) is 5α-reductase inhibitors (5ARI). Europe experienced recent safety issues involving 5ARI and depression symptoms, with similar findings being seen in Western countries. The South Korea has updated the drug label in accordance with European recommendations, but the relevant evidence was insufficient. This study compared the use of 5ARI versus α-blocker (AB) as a treatment for BPH and related risks of depression to provide evidence based on the Korean population.

This was a retrospective cohort study using South Korea's Health Insurance Review & Assessment Service claim data from 2011 to 2017. New patients diagnosed in men with BPH and taking medications that contained either 5ARI or AB between July 1, 2013, and June 30, 2015, were included (n = 1,461 5ARI; n = 18,650 AB). The primary outcome was depression defined per the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10 F32-34, F38, F412, F432).