Kilgoremahmoud6092

Electrocatalysts with high active oxygen reduction (ORR) and oxygen evolution reaction (OER) activities are key factors in renewable energy technologies. Unlike common strategies for adjusting the proportion of metal centers in a multi-metal organic framework (MOF), herein, we designed and synthesized bifunctional electrocatalysts using CTAB-capped ultra-low content platinum (Pt) (≤0.5 wt.% Pt) and copper (Cu) nanoparticles and doped on the surface of zinc-based MOF (Zn-MOF-74) and calcinated at 900 oC. According to the electrochemical activity, the Pt/Cu/NPC-900 exhibits superior catalytic activities towards both the ORR (Eo = 1.48 V and E1/2 = 0.89 V) and OER (Eo = 1.48 V and ղ = 0.265 V) in an alkaline electrolyte at ambient temperature. Also, Pt/Cu/NPC-900 catalyzes though a 4- electron process and exhibits superior stability. Such insightful findings, as well as a newly developed approach, provides rational design and synthesis of an economical and efficient strategy for bifunctional electrocatalyst development.When the skyrmion dynamics beyond the particle-like description is considered, this topological structure can deform due to a self-induced field. In this work, we perform Monte Carlo simulations to characterize the skyrmion deformation during its steady movement. In the low-velocity regime, the deformation in the skyrmion shape is quantified by an effective inertial mass, which is related to the dissipative force. When skyrmions move faster, the large self-induced deformation triggers topological transitions. These transitions are characterized by the proliferation of skyrmions and a different total topological charge, which is obtained as a function of the skyrmion velocity. Our findings provide an alternative way to describe the dynamics of a skyrmion that accounts for the deformations of its structure. Furthermore, such motion-induced topological phase transitions make it possible to control the number of ferromagnetic skyrmions through velocity effects.An enormous amount of environmental monitoring data has been acquired by various organizations for evaluation and implementation of countermeasure to mitigate the effects of the accident at the Fukushima Daiichi Nuclear Power Plant. However, it is difficult to collate, compare, and analyze these data because they were published in different formats at different sites according to the respective objectives of the publishing organizations. Moreover, these organizations have been accumulating data in large volumes for over nine years after the accident. We established procedures to collect these data, convert them into a unified format, classify them according to categories, and make the data accessible on a web-based database system. The database contains environmental monitoring data on air dose rates, ground deposition densities, and concentrations in various environmental samples such as soil, water, and food. These data are being provided not only in numerical format for quantitative analysis but also as distribution maps and time-series graphs for visual understanding. The database system enabled us to spatially and temporally compare large volumes of monitoring data. By using the database functions, characteristics of some representative data in the database were clarified.We examine the macroscopic deformation of a colloidal depletion gel subjected to a step shear stress. Three regimes are identified depending on the magnitude of the applied stress (i) for stresses below yield stress, the gel undergoes a weak creep in which the bulk deformation grows sublinearly with time similar to crystalline and amorphous solids. For stresses above yield stress, when the bulk deformation exceeds approximately the attraction range, the sublinear increase of deformation turns into a superlinear growth which signals the onset of non-linear rearrangements and yielding of the gel. However, the long-time creep after such superlinear growth shows two distinct behaviors (ii) under strong stresses, a viscous flow is reached in which the strain increases linearly with time. This indicates a complete yielding and flow of the gel. In stark contrast, (iii) for weak stresses, the gel after yielding starts to resolidify. More homogenous gels that are produced through enhancement of either interparticle attraction strength or strain amplitude of the oscillatory preshear, resolidify gradually. In contrast, in gels that are more heterogeneous resolidification occurs abruptly. We also find that heterogenous gels produced by oscillatory preshear at intermediate strain amplitude yield in a two-step process. Finally, the characteristic time for the onset of delayed yielding is found to follow a two-step decrease with increasing stress. This is comprised of an exponential decrease at low stresses, during which bond reformation is decisive and resolidification is detected, and a power law decrease at higher stresses where bond breaking and particle rearrangements dominate.Modulated structure of Ni-Mn-Ga-based alloys is decisive in their magnetic shape memory (MSM) functionality. However, the precise nature of their five-layered modulated 10M martensite is still an open question. We used x-ray and neutron diffraction experiments on single crystals to investigate structural changes within 10M-modulated martensite of the Ni50Mn27Ga22Fe1MSM alloy. The modulation vector gradually increases upon cooling from commensurateq= (2/5)g110, whereg110is the reciprocal lattice vector, to incommensurate withqup to pseudo-commensurateq= (3/7)g110. Upon heating, reverse changes are observed with a thermal hysteresis of ≈60 K. The same hysteretic behaviour was detected in the electrical resistivity and the effective elastic modulus. Scanning electron microscopy showed that the changes are accompanied by the refinement of thea/blaminate. These observations indicate that the commensurate state is a metastable form of 10M martensite. Upon cooling, this phase evolves through nanotwinning into a more irregular and more stable incommensurate structure.Objective.There have been many efforts to develop tools predictive of health deterioration in hospitalized patients, but comprehensive evaluation of their predictive ability is often lacking to guide implementation in clinical practice. Cordycepin In this work, we propose new techniques and metrics for evaluating the performance of predictive alert algorithms and illustrate the advantage of capturing the timeliness and the clinical burden of alerts through the example of the modified early warning score (MEWS) applied to the prediction of in-hospital code blue events.Approach. Different implementations of MEWS were calculated from available physiological parameter measurements collected from the electronic health records of ICU adult patients. The performance of MEWS was evaluated using conventional and a set of non-conventional metrics and approaches that take into account the timeliness and practicality of alarms as well as the false alarm burden.Main results. MEWS calculated using the worst-case measurement (i.e. values scoring 3 points in the MEWS definition) over 2 h intervals significantly reduced the false alarm rate by over 50% (from 0.19/h to 0.08/h) while maintaining similar sensitivity levels as MEWS calculated from raw measurements (∼80%). By considering a prediction horizon of 12 h preceding a code blue event, a significant improvement in the specificity (∼60%), the precision (∼155%), and the work-up to detection ratio (∼50%) could be achieved, at the cost of a relatively marginal decrease in sensitivity (∼10%).Significance. Performance aspects pertaining to the timeliness and burden of alarms can aid in understanding the potential utility of a predictive alarm algorithm in clinical settings.This study looked at the process of designing and synthesized expanded graphite (EG) and modifying it with bio-inspired dopamine (DOPA). link2 This is a process used to improve the thermal conductivity and dielectric properties of methyl vinyl silicone rubber (VMQ). The results demonstrated that the EG-DOPA-VMQ composites acquired an exceptional thermal conductivity of 1.015 W mK-1at the loading of 10 wt%, approximately 480% higher than that of pure silicone rubber (0.175 W mK-1). This enhancement is mainly attributed to the improved dispersion capability of EG-DOPA and the robust interfacial interaction between EG-DOPA-VMQ interfaces; specifically, this is the result when compared with pristine EG. Moreover, throughout this process, the composites maintained an excellent insulating property with a resistance of ≈1012Ω · cm; this particular result was due to the DOPA deposited on EG surfaces because they acted as an insulating layer, inhibiting the electron transfer in composites. Overall, this work demonstrated that it could present a promising strategy for synchronized manufacturing of polymer composites with high thermal conductivity and insulating capability.Commonly recognized mechanisms of the xenogeneic-extracellular matrix-based regenerative medicine include timely degradation, release of bioactive molecules, induced differentiation of stem cells, and well-controlled inflammation. This process is most feasible for stromal tissue reconstruction, yet unsuitable for non-degradable scaffold and prefabricated-shaped tissue regeneration, like odontogenesis. Treated dentin matrix (TDM) has been identified as a bioactive scaffold for dentin regeneration. This study explored xenogeneic porcine TDM (pTDM) for induced odontogenesis. The biological characteristics of pTDM were compared with human TDM (hTDM). To investigate its bioinductive capacities on allogeneic dental follicle cells (DFCs) in the inflammation microenvironment, pTDM populated with human DFCs were co-cultured with human peripheral blood mononuclear cells (hPBMCs), and pTDM populated with rat DFCs were transplanted into rat subcutaneous model. The results showed pTDM possessed similar mineral phases and bioactive molecules with hTDM. hDFCs, under the induction of pTDM and hTDM, expressed similar col-I, osteopontin and alkaline phosphatase (ALP) (all expressed by odontoblasts). Whereas, the expression of col-I, dentin matrix protein-1 (DMP-1) and bone sialoprotein (BSP) were down-regulated when cocultured with hPBMCs. The xenogeneic implants inevitably initiated Th1 inflammation (up-regulated CD8, TNF-α, IL-1β, etc)in vivo. However, the biomineralization of pre-dentin and cementum were still processed, and collagen fibrils, odontoblast-like cells, fibroblasts contributed to odontogenesis. Although partially absorbed at 3 weeks, the implants were positively expressed odontogenesis-related-proteins like col-I and DMP-1. Taken together, xenogeneic TDM conserved ultrastructure and molecules for introducing allogeneic DFCs to odontogenic differentiation, and promoting odontogenesis and biomineralizationin vivo. Yet effective immunomodulation methods warrant further explorations.Postoperative cognitive dysfunction (POCD) is a neurological complication of surgery especially common in elderly patients. In this study, we investigated the role of NONMMUT055714 in POCD via regulation of miR-7684-5p. In a POCD mouse model, we induced overexpression of NONMUTT055714 via transfection of lentivrus into the hippocampus, and used the Morris water maze for assessment of cognitive function. link3 Silencing of NONMUTT055714 and miR-7684-5p was induced in primary hippocampal neurons to observe the effects of these regulatory RNAs on cellular processes. Bioinformatics analysis and a double luciferase reporter experiment were performed to further explore the relationship between NONMMUT055714, miR-7684-5p, and SORLA. Cell and animal rescue experiments were performed to verify the ability of miR-7684-5p to reverse the protective effects of NONMMUT055714 overexpression in POCD. We observed that NONMMUT055714 has decreased expression in the POCD mouse model. Overexpression of NONMMUT055714 protected against cognitive impairment of the POCD mouse model in vivo.