Keyfallon1854

Objective To evaluate the diagnostic performance of Doppler sonography of umbilical artery (UA), fetal middle cerebral artery (MCA), ductus venosus (DV) & umbilical vein (UV) for prediction of adverse perinatal outcome.Material and Methods A prospective cohort study conducted on 60 women diagnosed  with preeclampsia with severe features divided into two groups based on adverse perinatal outcome.Results Statistically Significant differences were demonstrated UA PI (1.28 ± 0.23 vs. 0.96 ± 0.21, P less then 0.001), UA RI (0.78 ± 0.09 vs. 0.62 ± 0.09, P less then 0.001), MCA PI (1.27 ± 0.28 vs. 1.45±0.20, P 0.005), MCA RI (0.67 ± 0.10 vs. 0.76 ± 0.08, P less then 0.001), Cerebroplacental ratio (1.01 ± 0.36 vs. 1.57 ± 0.35, P less then 0.001), DV PVIV (0.67 ± 0.20 vs. 0.51 ± 0.14, P= 0.004), DV PSV (54.74 ± 17.11 vs. 42.15 ± 9.42, P= 0.004)  and abnormal DV a wave (23.8 vs. 0%, P = 0.004) in women with adverse and normal perinatal outcome respectively. UA PI and CPR had the highest specificity while UA RI had the highest sensitivity for detection of adverse perinatal outcome.Conclusion CPR less then 1 can be used to identify fetuses at risk of morbidity and mortality among such cases.Social network sites (SNS) have become an increasingly popular platform for providing and receiving social support. Traditionally, females are believed to offer more social support. However, investigations of both the offline and online domains have revealed mixed findings. This meta-analysis attempts to assess the presence and magnitude of gender differences in social support on SNS. A literature review produced a sample of 30 independent studies with 17,000 participants. Results showed that females on SNS give (d = 0.36) and receive (d = 0.14) greater social support than do males. This is the first meta-analysis to test for and demonstrate gender differences in social support, either offline or online.Objective to compare testosterone levels between female depressed patients and female bipolar patients.Methods Sixty-one female patients with major depressive disorder (MDD) (n = 23) or bipolar disorder (BD) (n = 38) between 18 and 45 years old were included in the study. Participants were evaluated during a depressive or manic episode with the Hamilton depression rating scale (HDRS) or Young mania rating scale (YMRS), respectively. No patients in the MDD group were taken valproate while in the BD group 14 (36.84%) were taken valproate. Total testosterone (TT) and free testosterone (FT) levels were quantified during the early follicular phase of the cycle, with radioimmunoassay or solid phase enzyme-linked immunoassay. Data were collected from May 2016 to February 2017.Results Mean TT serum levels were significantly higher in BD patients in comparison to MDD patients. Although age and diagnosis were related to TT levels, however when we added valproate use in the analysis, only the relation between TT and valproate use remained significant.Conclusions In this sample, TT levels were related to valproate use in patients with BD. More studies regarding the role of testosterone in affective symptoms should be conducted to clarify the relation between testosterone, affective disorders, and medication.KeypointsWe observed that testosterone levels were significant higher in bipolar women compared to women with MDD.The use of valproate could be associated with the testosterone levels in female patients with BD.Evaluation of women suffering BD should include a testosterone levels determination, particularly when they are taking valproate.Introduction Blood-based biomarkers can provide valuable information on the effects of repetitive head impacts in sports. This study investigated if repetitive headers or accidental head impacts in soccer could cause structural brain injury, detected as an increase in serum neurofilament light (NfL) or tau.Methods NfL and tau were measured in professional soccer players in pre-season. Then, the effect of three short-term exposures on biomarker levels was assessed (1) high-intensity exercise, (2) repetitive headers, and (3) head impacts in a match.Results We analyzed 354 samples and observed no effects on NfL from any of the three short-term exposures. Tau levels rose significantly from baseline to 1 h after (1) high-intensity exercise (Δ0.50 pg/mL, 95% CI 0.19-0.81, p less then  .01); the same was observed after (2) repetitive headers (Δ0.29 pg/mL, 95% CI 0.10-0.48, p less then  .01), but not after (3) accidental head-impact incidents (Δ0.36 pg/mL, 95% CI -0.02-0.74, p = .06). The highest absolute values were seen 1 h after high-intensity exercise (mean±SD, 1.92 ± 0.83 pg/mL).Conclusion NfL and tau in serum were unaffected by head impacts in soccer. Importantly, tau levels seem to rise in response to exercise, emphasizing the need for control groups. Our findings highlight important characteristics and limitations when using these biomarkers in sports.Aim Little is known about the association between specific primary lymph node (LN) sites and the risk of developing second primary cancers in Hodgkin lymphoma (HL) patients. Materials & methods To fill this knowledge gap, we used the multiple primary standardized incidence ratio function of the SEER*stat program to explore such an association for multiple latency periods. Results Several SPCs occurred at various time points following different primary LN presentations of HL. Conclusion HL survivors may benefit from a tailored primary LN site-specific follow-up screening.This study sought to examine whether interpersonal goals can help us understand who engages in social-capital-building responsive behaviors and envy-eliciting passive behaviors on Facebook. One hundred eighty-eight adults completed measures of interpersonal goals (compassionate and self-image), Facebook use (posting, responding, and searching), social capital sources and benefits, social comparison, and envy, along with various control measures. Serial mediation analyses revealed that compassionate goals significantly predicted four distinct social capital benefits (offline participation, emotional support, horizon broadening, and networking value) through greater Facebook responding and sources of social capital. Furthermore, self-image goals significantly predicted envy through greater Facebook searching and social comparison. These effects were significant with and without controlling for age, gender, Facebook friends, Facebook frequency, Facebook hours, self-esteem, attachment style, social desirability, and the other interpersonal goal and Facebook behaviors. Consistent with research on interpersonal goals in offline interactions, compassionate goals predicted more responsive behaviors and better social outcomes, while self-image goals predicted a competitive mindset and negative emotion. These findings extend the social networking site (SNS) literature by identifying a relevant new individual difference associated with SNS use and key outcomes related to well-being.We designed and fabricated, using low-cost 3D printing technologies, a device that enables direct control of cell density in epithelial monolayers. The device operates by varying the tension of a silicone substrate upon which the cells are adhered. Multiple devices can be manufactured easily and placed in any standard incubator. This allows long-term culturing of cells on pretensioned substrates until the user decreases the tension, thereby inducing compressive forces in plane and subsequent instantaneous cell crowding. Moreover, the low-profile device is completely portable and can be mounted directly onto an inverted optical microscope. This enables visualization of the morphology and dynamics of living cells in stretched or compressed conditions using a wide range of high-resolution microscopy techniques.Limited research has examined bidirectional associations between modern media (e.g., smartphone, tablet) use and behavior in early childhood. This study aimed to test the hypotheses that, over 6 months, (H1) child externalizing behavior would predict later media use, mediated by parenting stress, and (H2) media use would predict later externalizing behavior. Participants included mothers and fathers from 183 heterosexual couples with a child 1-5 years old, followed for 6 months-assessed at baseline, 1, and 6 months. Frequency of child media use was assessed at baseline and 6 months through parent report across eight items (e.g., television [TV], smartphone, tablet use). Child externalizing behavior was assessed through the Child Behavioral Checklist, and parent stress through the Parenting Stress Index. Hypotheses were tested using structural equation modeling. Mothers were 31.8 (standard deviation [SD] = 4.2), fathers 33.3 (SD = 4.9), and children 3.0 years old (SD = 1.2). Structural equation models showed good overall fit. As hypothesized, we found that (H1) greater child externalizing behavior predicted greater parenting stress (β = 0.48, p  less then  0.001), which predicted increases in child media use (β = 0.15, p  less then  0.05); however, (H2) child media use did not predict later externalizing behavior (β = 0.06, p = 0.23). In post hoc analyses, results differed slightly by specific type of media; for example, externalizing behavior was associated with later tablet and game use, whereas TV use predicted increases in externalizing behavior. Our results suggest that child behavior problems associate with later media use habits, possibly as a parent coping strategy, which should be considered when providing clinical guidance.Objective To perform evaluations of the CONTOUR PLUS LINK 2.4 blood glucose monitoring system (BGMS) assessed according to ISO 151972013 criteria.Methods Clinical trial registered at ClinicalTrials.gov (NCT01824355). In a laboratory study (Study 1), capillary fingertip blood samples from 100 subjects were evaluated in duplicate, using three test strip lots. In a clinical trial (Study 2), 113 adults with diabetes were enrolled, and BGMS results and Yellow Springs Instruments (YSI) analyzer reference measurements were compared for subject- and trial staff-obtained fingertip blood and subject-obtained palm blood. Subjects completed a questionnaire to evaluate BGMS ease of use.Results In Study 1, 100% of combined results (all test strip lots) fulfilled ISO 151972013 section 6.3 criteria. In Study 2, 97.7% of subject-obtained fingertip results and 100% of trial staff-obtained fingertip results met ISO 151972013 section 8 criteria. Additionally, 93.8% of palm results were within ± 15 mg/dL of mean YSI measurements for glucose concentrations less then 100 mg/dL or ± 15% for glucose concentrations ≥100 mg/dL. Most subjects found the BGMS easy to use. There were three non-serious, non-device related adverse events.Conclusion The BGMS exceeded minimum ISO 151972013-specified accuracy criteria in the laboratory and in the hands of lay users with diabetes.Lung adenocarcinoma (LUAD) accounts for an increasing proportion of non-small-cell lung cancer and an increasing number of cancer-related deaths worldwide. However, few biomarkers are available for prognosis and patient stratification. In all eight datasets from the Oncomine and The Cancer Genome Atlas (TCGA) LUAD cohorts, solute carrier family 2 member 1 (SLC2A1) was significantly more highly expressed in LUAD tissue than in normal lung tissue. High SLC2A1 expression was also significantly (p  less then  0.05) associated with a poor prognosis in stage I, II, and III subgroups using the Kaplan-Meier plotter. In the National Cancer Center of China (NCC) cohort, SLC2A1 expression correlated significantly (p  less then  0.05) with several parameters, including sex, smoking history, tumor size, tumor differentiation, T stage, N stage, and pathologic TNM stage. Moreover, multivariate Cox regression indicated SLC2A1 to be an independent prognostic factor (p  less then  0.05) in both TCGA and NCC cohorts. Eleven hallmark pathways were significantly enriched (p  less then  0.