Kesslercoffey3691

To investigate the influence of age, gender and underlying disease on the optical coherence tomography (OCT) features of choroidal neovascularization (CNV) secondary to Inflammation (iCNV), myopia (mCNV) and age-related macular degeneration (AMD-CNV).

Demographic and clinical data of eyes with treatment naïve iCNV, mCNV and type 2 AMD-CNV were collected. OCT images were reviewed to determine the presence of pitchfork sign (PFS), pigment epithelial detachment (PED), subretinal fluid (SRF), intraretinal cysts (IRC), subretinal hyper reflective material (SHRM), atrophy and outer retinal disruption (ORD) graded 1 to 4. The influence of demographics and underlying etiology on OCT signs was investigated.

185 eyes from 179 patients were enrolled. The mean[SD] age was 36[±14.4], 62[±18] and 77[±8] for the iCNV, mCNV and AMD-CNV respectively (p<0.001). Multiple linear regression showed that the presence of PFS was negatively associated with age (p<0.0001) regardless of underlying disease. By contrast the SRF, PED, IRC and the ORD were all positively influenced by age regardless of gender and underlying disease (all p<0.01). Logistic regression showed that none of the OCT signs increased the likelihood for diagnosis of iCNV. By contrast, absence of SRF was suggestive for mCNV and presence of PED and SRF was suggestive for AMD-CNVs.

The age of the patient had a significant effect on the OCT appearance of the CNV, particularly the presence of a PFS, regardless of the underlying etiology. The absence of SRF was suggestive for a diagnosis of mCNV. The presence of SRF and PED was suggestive for AMD-CNVs.

The age of the patient had a significant effect on the OCT appearance of the CNV, particularly the presence of a PFS, regardless of the underlying etiology. The absence of SRF was suggestive for a diagnosis of mCNV. The presence of SRF and PED was suggestive for AMD-CNVs.

Comparing the anatomical and functional outcomes of vitrectomy, silicone oil endotamponade without cyclopexy (VEWOC) and with cyclopexy (VEWC) in patients with traumatic cyclodialysis clefts and severe ocular comorbidities.

A total of 55 patients (55 eyes) with traumatic cyclodialysis clefts were divided into VEWOC and VEWC groups according to the surgery undergone. Besides the cyclodialysis clefts, all study eyes had one or more additional conditions caused by severe ocular trauma cataract, lens dislocation, vitreous hemorrhage, retinal detachment, choroidal detachment, maculopathy, suprachoroidal hemorrhage, sub-retinal hemorrhage, or proliferative vitreoretinopathy. The minimum postoperative follow-up period for all patients was six months. The main measures of outcome were rate of successful anatomical repair, intraocular pressure (IOP), and best-corrected visual acuity (BCVA).

Both the VEWOC group (33 eyes) and the VEWC group (22 eyes) showed significant improvement in postoperative BCVA and IOP athe vitrectomy procedure in such cases.

To evaluate the neovascular age-related macular degeneration (nAMD) course after endophthalmitis.

Multicenter, retrospective series.

From 4/2013-10/2018, 196,598 intravitreal anti-VEGF injections were performed, with 75 cases of endophthalmitis (incidence 0.0381%). There was no association between intravitreal anti-VEGF drug (p=0.29), anesthetic method (p=0.26), povidone concentration (p=0.22), or any intra-procedure variable and endophthalmitis incidence. Seventy-two patients (96%) were treated with intravitreal tap & inject (vs 3 with pars plana vitrectomy). After endophthalmitis resolution, 17 patients (22.7%) were not re-treated for nAMD (inactive disease - 10 cases; follow-up 115±8.4 weeks). Patients required less frequent anti-VEGF injections post-infection (7.4±0.61 weeks vs 11.5±1.8 weeks; p=0.004). LogMAR visual acuity (VA) pre-infection was 0.585±0.053 (∼20/77). It worsened with endophthalmitis (1.67±0.08, ∼20/935; p<0.001) and again on POD1 (1.94±0.064, Count Fingers; p<0.001), but improved after re-initiating nAMD therapy (1.02±0.11, ∼20/209; p<0.001). Better VA on post-endophthalmitis week 1 (p=0.002) and reinitiation of nAMD treatment (p=0.008) were associated with better final VA, streptococcal culture with worse VA (p=0.028). The post-endophthalmitis treatment interval was associated with the anti-VEGF drug (aflibercept = ranibizumab > bevacizumab; p<0.001).

Patients with nAMD required fewer injections after endophthalmitis, suggesting a biological change in disease activity. Endotoxin nAMD became quiescent in 13.3% of eyes. Most achieved better outcomes with anti-VEGF reinitiation.

Patients with nAMD required fewer injections after endophthalmitis, suggesting a biological change in disease activity. nAMD became quiescent in 13.3% of eyes. Most achieved better outcomes with anti-VEGF reinitiation.

To evaluate the efficacy of posterior scleral contraction (PSC) to treat myopic foveoschisis (MF).

The records of MF patients treated with PSC were reviewed. During PSC, a cross-linked fusiform strip from allogeneic sclera was used and designed axial length (AL) shortening amount was around 2.0∼3.0mm based on preoperative AL. The middle part of the strip was placed at posterior pole of the eye. After few aqueous humors were released, the strip was tightened to contract posterior sclera and shorten AL. Clinical data were collected at pre-operation (op) and post-op follow-ups for 12 months.

Twenty-four eyes were collected. The AL at pre-op, post-op 1-week, 3-month, 6-month and 12-month were 29.84±1.24, 27.39±1.32, 27.73±1.23, 27.86±1.26, and 27.91±1.29mm. There was no AL difference between post-op 6-month and 12-month (P=0.242). The accumulated MF reattachment rate at post-op 1-week, 3-month, 6-month, and 12-month were 8.3%, 16.7%, 50.5% and 95.8%. The best-corrected visual acuity (BCVA) at post-op 6-month and 12-month were 0.71±0.39 (Snellen acuity 20/80) and 0.64±0.37 (Snellen acuity 20/63), improving significantly compared to pre-op (P=0.006 and <0.001).

The PSC was effective to treat MF. The AL stabilized after post-op 6-month and MF reattached gradually with improved visual acuity up to post-op 12-month.

The PSC was effective to treat MF. The AL stabilized after post-op 6-month and MF reattached gradually with improved visual acuity up to post-op 12-month.