Kesslercantu3167

Several methods aid with reconstructing features of the human nose, including angle, projection and width, but only one study by Davy-Jow et al. (2012) has focused on nose tip shape. The main finding was that the shape of the nasal bridge is consistent with the shape of the nose tip. The study also theorised that the method would not be suitable for snub (upturned) noses. Although promising, further investigation with a larger sample of different origin would be of benefit. In addition, grouping samples into upturned, horizontal and downturned nose tips could reveal the need for a difference in the applied method. The approach has been recreated with a larger sample size (N = 103 versus N = 25) derived from a modern German population. Based on soft tissue models, the individuals were firstly grouped into three categories; upturned, horizontal, and downturned noses. Computed Tomography (CT) data allowed the simultaneous visualisation of both skull and (semi-transparent) facial surfaces. Each head was viewed frontally in the Frankfurt Horizontal Plane (FHP), and then tilted back until the nasal tip superimposed the nasal bridge, with the angle of tilt measured from the FHP. The results show that the angle of tilt is significantly different for upturned, horizontal, and downturned noses, but that it can be equally applied to all three groups. The mean angle was 44° for upturned noses, 51° for horizontal, and 56° for downturned. Error studies suggest a very high accuracy and repeatability with intra-class correlation coefficients of 0.991 (inter-observer error) and 0.972 (intra-observer error) respectively.Age estimation is an integral part of forensic medical and dental practice. In many countries, the age threshold of 14 years is set to determine the minimum age for criminal responsibility. In the present study, the authors studied the final maturation of the first (IPM1) and second mandibular premolars (IPM2) by Cameriere maturity index and determined cut-offs at the age threshold of 14 years, and validate on the test sample. Orthopantomograms of 960 healthy south Indian children and sub-adults (480 boys and 480 girls) aged between 10 and 18 were analysed, 640 as training sample and 320 as a test sample. The results of logistic regression analysis with age ( less then /≥14 years) as a dependent variable and IPM1, IPM2, and sex as predictor variables on training sample showed that both IPM1 and IPM2 significantly related to the legal age of 14 years but not the sex (p = 0.052). A receiver operating characteristic (ROC) curve analysis was performed to evaluate the specific cut-off values of IPM1 and IPM2 for predicting 14 years. A cut- off value of IPM1 less then 0.01 and IPM2 less then 0.02 were obtained using the highest Youden index value. Our results on test sample showed that the combined predictor, IPM1 + IPM2 less then 0.02, showed the highest specificity (97.5% in boys and 92.5% for girls), better post-test probability, 97.2% in boys and 91.9% for girls, and a smaller number of false positives (6.8%). In conclusion, the combination of IPM1 and IPM2 could be useful in determining the age of over 14 years in south Indian children.Maize (Zea mays) is one of the most widely grown crops in the world, with an annual global production of over 1147 million tons. Genomics approaches are thought to be the best solution for accelerating yield improvement to meet the challenges of a growing population and global climate change. Here, we review current approaches to the exploration of novel genetic variation in genomes, DNA modifications, and transcription levels of cultivated maize, landraces, and wild relatives. We discuss applications of genetic engineering to maize yield improvement and highlight future directions for maize genomics studies.To develop more productive and resilient crops that are capable of feeding 10 billion people by 2050, we must accelerate the rate of genetic improvement in plant breeding programs. Speed breeding manipulates the growing environment by regulating light and temperature for the purpose of rapid generation advance. Protocols are now available for a range of short-day and long-day species and the approach is highly compatible with other cutting-edge breeding tools such as genomic selection. Here, we highlight how speed breeding hijacks biological processes for applied plant breeding outcomes and provide a case study examining wheat growth and development under speed breeding conditions. The establishment of speed breeding facilities worldwide is expected to provide benefits for capacity building, discovery research, pre-breeding, and plant breeding to accelerate the development of productive and robust crops.The triplication of human chromosome 21 results in Down syndrome (DS), the most common genetic form of intellectual disability. This aneuploid condition also results in an enhanced risk of a spectrum of comorbid conditions, such as leukemia, early onset Alzheimer's disease, and diabetes. Individuals with DS also display an increased incidence of wound healing complications and resistance to solid tumor development. Due to this unique phenotype and the involvement of eicosanoids in key comorbidities like poor healing and tumor development, we hypothesized that cells from DS individuals would display altered eicosanoid production. Using age- and sex-matched dermal fibroblasts we interrogated this hypothesis. Briefly, assessment of over 90 metabolites derived from cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome p450 systems revealed a possible deficiency in the COX system. check details Basal gene expression and Western blotting experiments showed significantly decreased gene expression of COX1 and 2, and COX2 protein abundance in DS fibroblasts compared to euploid controls. Further, using two different stressors, scratch wound or LPS, we found that DS fibroblasts could not upregulate COX2 abundance and prostaglandin E2 production. Together, these findings show that dermal fibroblasts from DS individuals have a deficient COX2 response, which may contribute to wound healing complications and tumor resistance in DS.Health risks due to NO2 exposure commonly exceed acceptable levels in modern societies. Among the measures to reduce such risks, photocatalytic materials present a promising technology. However, while the pollutant remediation of such materials has been extensively validated in laboratory studies, the performance under real world environmental exposure conditions is still subject to controversy. Indeed, a comparison of available in-situ monitoring studies manifests non-conclusive and highly scattered results regarding the photocatalytic effectiveness observed. The reasons for this behaviour must be carefully explored in order to prevent non-efficient photocatalytic applications from being put into practice on a larger scale. This paper presents a comprehensive large-scale study for assessing the photocatalytic NO2 remediation by active pavements in a street of Madrid (Spain), comprising different in-situ monitoring techniques. The discussion is enriched by relating the obtained results to those of other large-scale studies. The discrepancies between these results may be traced back to different circumstances, among them the distance between the active pavement and the pollutant concentration sampling inlet, as well as to significant site-specific and time-dependent variations of pollutant concentrations and climatic parameters. Under due consideration of these influences, for materials with relatively high initial effectiveness, it was concluded that in most such applications, the average NO2 removal effectiveness, if evaluated at a typical inlet height of Air Quality Stations (3 m), will not exceed a value of 4% (averaged over a sufficiently large number of measurement points in the area of application and a sustained amount of time, i.e. several months). When considering more realistic human exposure conditions (lower heights and daytime), it might be justified to assume somewhat higher average effectiveness.On-site wastewater treatment systems are gaining popularity in areas where centralized wastewater treatment is not available. In the current case study a domestic activated sludge system was investigated, where treated effluent was stored in a short-term (1 week turn-over time) and a long-term (over 2-3 months) storage tank and was then used for irrigation. This design provided a unique opportunity to assess the chemical and microbial changes of the effluent upon storage. Long-term storage greatly improved both the chemical quality and the degradation efficiency of most organic micropollutants examined, including petroleum hydrocarbons and the pesticide diethyltoluamide. Taxonomic profile of the core microbiome of the effluent was also influenced upon storage. Relative abundance values of the members of Azoarcus and Thauera genera, which are important in degrading polycyclic aromatic hydrocarbons compounds, clearly indicated the biodegrading activity of these microbes across samples. The abundance of xenobiotics degradation functions correlated with the observed organic micropollutant degradation values indicating efficient microbial decomposition of these contaminants. Functions related to infectious diseases also had the highest abundance in the short-term storage tank corresponding well with the relative abundance of indicator organisms and implying to the significance of storage time in the elimination of pathogens. Based on these results, small, on-site wastewater treatment systems could benefit from long-term storage of wastewater effluent.Negative emissions technologies (NETs), which remove and isolate carbon dioxide from the atmosphere, are expected to play a significant role in mitigating climate change. As one of the most promising NETs, bioenergy with carbon capture and storage (BECCS) methods, which captures carbon dioxide (CO2) emissions from bioenergy plants and then stores them in geological reservoirs, are being widely used in climate change scenarios. With the increased focus on mitigating solutions, several concerns have been raised regarding the deployment of BECCS. As no science mapping analyses of evolutionary BECCS patterns have yet been made, this study sought to determine these evolution patterns using a systematic analysis approach based on science mapping and visualization analyses. Under a longitudinal framework, the conceptual BECCS evolutionary track was determined using SciMAT to elucidate the structure and dynamic aspects of the associated scientific research. The co-word network and thematic evolutionary analysis revealed five main BECCS related themes. While this study provides a systematic study of BECCS research and development, further research should continue to focus on techno-economic analyses and the ecological and environmental impacts (land-use, water, diversity, and bioenergy crops) of BECCS. An increased research focus on the emerging biochar and hydrogen production themes is expected.A flexible, durable, and reusable nanocatalyst system was fabricated by anchoring palladium nanoparticles on carbon nanotube (CNT) carpets covalently attached to carbon cloth. These hierarchical hybrid materials were tested for catalytic degradation of triclosan (TCS), an emerging contaminant. Materials were characterized using scanning & transmission electron microscopy techniques (SEM and TEM), X-Ray Diffraction (XRD), and X-Ray Photoelectron Spectroscopy (XPS). The reaction kinetics was studied using HPLC and reaction pathways proposed based on LC-MS/GC-MS analyses. In the presence of hydrogen, complete step-wise chlorine removal was seen until complete dechlorination was accomplished. The pseudo-first-order rate constant was measured to be orders of magnitude higher than earlier reported values. Moreover, the same material was usable for multiple cycles in flowing water. This study demonstrates that robustness and reusability of larger structural materials can be combined with the ultra-high surface activity of nanocatalysts to provide practical and eco-friendly solutions for water sustainability.