Kellerschmitt6900

US Soccer eliminated soccer heading for youth players ages 10 years and younger and limited soccer heading for children ages 11-13 years. Limited empirical evidence associates soccer heading during early adolescence with medium-to-long-term behavioral deficits. The purpose of this study was to compare sensory reweighting for upright stance between college-aged soccer players who began soccer heading ages 10 years and younger (AFE ≤ 10) and those who began soccer heading after age 10 (AFE > 10). Thirty soccer players self-reported age of first exposure (AFE) to soccer heading. Sensory reweighting was compared between AFE ≤ 10 and AFE > 10. To evaluate sensory reweighting, we simultaneously perturbed upright stance with visual, vestibular, and proprioceptive stimulation. The visual stimulus was presented at two different amplitudes to measure the change in gain to vision, an intra-modal effect; and change in gain to galvanic vestibular stimulus (GVS) and vibration, both inter-modal effects. There were no differences in gain to vision (p=0.857, η2=0.001), GVS (p=0.971, η2=0.000), or vibration (p=0.974, η2=0.000) between groups. There were no differences in sensory reweighting for upright stance between AFE ≤ 10 and AFE > 10, suggesting that soccer heading during early adolescence is not associated with balance deficits in college-aged soccer players, notwithstanding potential deficits in other markers of neurological function. © Georg Thieme Verlag KG Stuttgart · New York.BACKGROUND  International guidelines have endorsed the use of edoxaban or rivaroxaban as an alternative to low-molecular-weight heparin (LMWH) for the treatment of acute venous thromboembolism (VTE) in cancer patients. Recently, a large randomized controlled trial of apixaban versus dalteparin in patients with cancer was completed. We performed an updated meta-analysis to assess the efficacy and safety of direct oral anticoagulants (DOACs) versus LMWH in patients with cancer-associated VTE. METHODS  MEDLINE, EMBASE, and CENTRAL (Cochrane Controlled Trials Registry) were systematically searched up to March 30, 2020 for randomized controlled trials comparing DOACs versus LMWH for the treatment of VTE in patients with cancer. The two coprimary outcomes were recurrent VTE and major bleeding at 6 months. Data were pooled by the Mantel-Haenszel method and compared by relative risk ratios (RRs) and 95% confidence intervals (CIs). RESULTS  Four randomized controlled studies (2,894 patients) comparing apixaban, edoxaban, or rivaroxaban with dalteparin were included in the meta-analysis. Recurrent VTE occurred in 75 of 1,446 patients (5.2%) treated with oral factor Xa inhibitors and in 119 of 1,448 patients (8.2%) treated with LMWH (RR 0.62; 95% CI 0.43-0.91; I 2, 30%). Major bleeding occurred in 62 (4.3%) and 48 (3.3%) patients receiving oral factor Xa inhibitors or LMWH, respectively (RR 1.31; 95% CI 0.83-2.08; I 2, 23%). CONCLUSION  In patients with cancer-associated VTE, oral factor Xa inhibitors reduced the risk of recurrent VTE without a significantly higher likelihood of major bleeding at 6 months compared with LMWH. Georg Thieme Verlag KG Stuttgart · New York.in English, German ZIEL  Die Forschung über den Einsatz von Ultraschall zur Untersuchung des Beckenbodens bei Frauen wird selten mit Introitus-Sonografie durchgeführt. Ziel dieser Studie war es, die Leistungsfähigkeit der 4-dimensionalen (4D) Introitus-Sonografie bei der perioperativen Beurteilung der Funktion der Beckenbodenmuskulatur (PFM) bei Frauen mit Zystozele zu untersuchen. MATERIAL UND METHODEN  Die Reliabilität und Übereinstimmung der Ultraschallmessungen wurden bei 20 Frauen mittels Intraklassen-Korrelationskoeffizienten (ICC) mit 95 %-Konfidenzintervall und Bland-Altman-Analyse bestimmt. Die Validität der Ultraschallparameter wurde bei 317 Frauen durch Korrelation der Ultraschallmessungen beim Pressen mit der modifizierten Oxford-Skala (MOS) beurteilt. Daten der 4D-Introitus-Sonografie von 241 Frauen mit (n = 29) und ohne (n = 212) postoperative Zystozele in der 12-monatigen postoperativen Erfassung wurden retrospektiv analysiert. Eine Levator-Avulsion wurde mittels tomografischen Ultraschalls diagnostiziert. Die nichtwillentlichen und willentlichen PFM-Funktionen wurden durch dynamische Veränderungen im Blasenhals bzw. im genitalen Hiatus beim Husten und Pressen im 4D-Introital-Ultraschall untersucht. ERGEBNISSE  Die ICC für die Reliabilität aller untersuchten Ultraschallparameter war gut bis sehr gut. Bei den meisten Ultraschallmessungen waren die Änderungen und die Änderungsverhältnisse zwischen Ruhezustand und Pressen ordentlich mit der MOS korreliert. Frauen mit postoperativer Zystozele zeigten im Vergleich zu Frauen ohne eine höhere Rate an vollständiger Levator-Avulsion (41,3 % vs. 4,7 %; p  less then  0,001; Odds-Ratio (OR) 14,26; 95 %-Konfidenzintervall (CI) 4,88–42,42) und eine geringere Fähigkeit zur willentlichen PFM-Kontraktion (65,5 % vs. 92,5 %; p  less then  0,001; OR 0,16; 95 %-CI 0,06–0,43). SCHLUSSFOLGERUNG  Die 4D-Introitus-Sonografie ist zur Beurteilung der perioperativen PFM-Funktion bei Frauen mit Zystozele durchführbar.In the context of the 'Mobile Haemophilia Outpatient Care (MHOC)' project we aimed to gather insights into the health-related quality of life (HRQoL), treatment satisfaction (TS) and adherence of persons with haemophilia (PWHs) who get treated at the Saarland University Hospital Haemophilia Treatment Centre (HTC). PWHs were visited at home at least twice (baseline, follow-up) by trained medical staff. Individual interviews were performed to measure patients' HRQoL and TS with validated questionnaires (Haem-A-QoL/Haemo-QoL and Hemo-SatA/Hemo-SatP). Socio-demographic and clinical data were collected. In total, 79 PWHs were enrolled; 56 adults with a mean age of 37.4 ± 16.4 years (17-78) and 23 children [mean age of 9.8 ± 4.2 years (3-16)]. Neuronal Signaling agonist In total, 62% were severely affected; 48.1% received prophylaxis. Patients reported good HRQoL (adults 23.1 ± 17.1; kids 24.3 ± 11.1). Patients (M = 11.2 ± 9.5) and parents (M = 14.3 ± 7.4) were very satisfied with their provided treatment. The majority of study participants were evaluated to have a good treatment adherence.