Kearneypoe2485

This study evaluated diagnostic accuracy of intraoperative sentinel lymph node (SLN) frozen section examination and scrape cytology as a possible solution for management of SLN positive patients.

Clinically early-stage endometrial cancer patients who underwent SLN algorithm and intraoperative SLN examination were analyzed. Findings were compared with final pathology results and diagnostic accuracy of frozen section and scrape cytology were evaluated.

Of the 208 eligible patients, 100 patients (48 %) had frozen section examination and 108 (52 %) had scrape cytology of the SLN. Intraoperative examination and final pathology were negative for metastasis in 187/208 (90 %) cases. The rest 21 cases had metastatic SLNs according to final pathology. 12 of 21 (57 %) metastases were classified as macrometastasis. Intraoperative examination of SLNs correctly identified 13 cases (true positive) and missed 8 cases (false negative). Five of 8 false negative cases had micrometastasis or isolated tumor cells. Considering identification of macrometastasis, sensitivity and negative predictive value were 85.71 % and 98.94 %, respectively, for the frozen section and 60.00 % and 98.15 %, respectively, for the scrape cytology.

Frozen section examination of SLN has higher sensitivity in detecting macrometastasis compared to scrape cytology and it could help the surgeon in decision for further lymphadenectomy intraoperatively.

Frozen section examination of SLN has higher sensitivity in detecting macrometastasis compared to scrape cytology and it could help the surgeon in decision for further lymphadenectomy intraoperatively.

Due to the evolution of hysteroscopic instruments, therapeutic hysteroscopic procedures are increasingly performed in an outpatient, office-based setting. The most important limiting factor of performing these hysteroscopic treatments is patient discomfort. Procedural Sedation Analgesia (PSA) decreases patient discomfort and anxiety. The main goal of this study is to determine safety, feasibility and patient satisfaction of therapeutic hysteroscopy performed under procedural sedation in an outpatient clinic. Our second objective was to compare 9 mm scopes with smaller diameter scopes.

All consecutive patients suitable for procedural sedation and scheduled for a therapeutic hysteroscopy in the outpatient clinic were prospectively included from February 2014 to November 2018 in a teaching hospital in the Netherlands. A variety of therapeutic hysteroscopies procedures was performed including myomectomy, removal of retained products of conception and endometrial ablation. Therapeutic hysteroscopes with 3.8 mmopy under procedural sedation in an outpatient setting, with low pain scores and a high degree of patient satisfaction, also when large diameter instruments are used.

It is safe and feasible to perform a therapeutic hysteroscopy under procedural sedation in an outpatient setting, with low pain scores and a high degree of patient satisfaction, also when large diameter instruments are used.H65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis infection in mice. In this study, we evaluated the impact of combining BCG with H65 + CAF01 immunization in a M. bovis mouse model of infection. We found that a BCG-H65 + CAF01/ H65 + CAF01 prime-boost scheme induced higher protection than BCG and H65 + CAF01 alone. Altogether, H65 antigen formulated in liposomal adjuvant improved the BCG-induced immune protection, thus making this vaccine strategy a promising tool to control bovine tuberculosis.

Self-similarity is a scale-invariant irregularity that can assist in designing a robust superhydrophobic material. A combinatorial design strategy involving self-similarity and dual-length scale can be employed to create a new library of a doubly re-entrant, disordered, and porous network of superhydrophobic materials. Asymmetric wettability can be engineered in nonwoven materials by rendering them with superhydrophobic characteristics on one side.

A facile, scalable, and inexpensive spray-coating technique was used to decorate the weakly hydrophobicstearate-treatedtitanate nanowires (TiONWs)over the self-similar nonwoven material. Laser scanning confocal microscopy was employed to image the impalement dynamics in three dimensions. With the aid of X-ray microcomputed tomography analysis, the three-dimensional (3D) nonwoven structural parameters were obtained and analyzed. The underwater superhydrophobic behavior of the prepared samples was investigated.

A classic 'lotus effect' has been successfully endowed in self-similar nonwoven-titanate nanostructured materials (SS-Ti-NMs) from a nonwoven material that housed the air pockets in bulk and water repellent TiONWs on the surface. NSC2382 The finer fiber-based SS-Ti-NMs exhibited lower roll-off angles and a thinner layer of water on its surface. An asymmetric wettability and the unusual display of underwater superhydrophobic behavior of SS-Ti-NMs have been uncovered.

A classic 'lotus effect' has been successfully endowed in self-similar nonwoven-titanate nanostructured materials (SS-Ti-NMs) from a nonwoven material that housed the air pockets in bulk and water repellent TiONWs on the surface. The finer fiber-based SS-Ti-NMs exhibited lower roll-off angles and a thinner layer of water on its surface. An asymmetric wettability and the unusual display of underwater superhydrophobic behavior of SS-Ti-NMs have been uncovered.This work addresses the role of rigid inclusions in determining the elastic modulus of particle-filled colloidal networks by modifying an established fractal scaling model. The approach acknowledges the heterogeneous nature of stress distribution at length scales beyond the colloidal aggregates, while maintaining structural information at the level of individual clusters. This was achieved by introducing a scaling factor to account for system heterogeneity which contains intrinsic information about the network's capacity to form load-bearing links. Rigid fillers bound to the network induce stress concentration, but additionally serve as junction zones which introduce additional load-bearing pathways. This gives rise to the observed increase in the modulus with filler volume fraction. The proposed relationship between the load-bearing network connectivity and scaling behavior may have additional implications on the fractal dimension determined by rheological methods. Further, this model accommodates an experimentally observed correlation between the scaling behavior of the modulus associated with the addition of fillers and that arising from increasing structurant concentration.