Kanstrupbruhn6653

In this paper, the heterogeneous Fenton like-reaction for Arsenic-contaminated groundwater remediation based on the performance of FeSO4 as an efficient and green catalyst and CaO2 as a source of H2O2 was investigated. To intensify the heterogeneous Fenton process, three oxidants were tested sodium percarbonate (SPC), sodium persulfate (SPS), and calcium peroxide (CP). The results showed that CP and SPC had a synergetic effect on the rate of Arsenic degradation, while SPS had an antagonistic effect. On the other hand, inorganic ions such as Na+, Mg2+ have a very low impact on the Arsenic removal efficiency, while the anions Cl- and NO3- exhibited significant inhibition of Arsenic degradation. This effect may be imputed to the reaction and conversion of hydroxyl (HO•) radicals to less reactive. Thus, HCO3- and humic acid dramatically raised the degradation rate. Also, the response Surface method based on Box-Behnken design was applied to examine the suitable modeling, and optimized condition of the Fenton like-reaction process, the maximum Arsenic removal efficiency of 94.91% is obtained when [Fe3+]0 = 1.97 mM, [CaO2]0 = 1.74 mM and initial pH = 4.67. The obtained results showed that the Fenton-like reaction is an effective and reliable process for arsenic removal from groundwater with low non-carcinogenic risk (HQ) and carcinogenic risk (CR) values.

Results from observational and experimental studies indicate that exposure to air pollutants during gestation reduces birth weight, whereas little is known on potential cardiometabolic consequences for the offspring at adulthood.

Our aim was to evaluate the long-term effects of gestational exposure to diesel engine exhaust (DE) on adult offspring phenotype in a rabbit model.

The protocol was designed to mimic human exposure in large European cities. Females rabbits were exposed to diluted (1mg/m

) DE (exposed, n=9) or clean air (controls, n=7), from 3 days after mating, 2h/d and 5d/wk in a nose-only inhalation system throughout gestation (gestation days 3-27). After birth and weaning, 72 offspring (47 exposed and 25 controls) were raised until adulthood (7.5 months) to evaluate their cardio-metabolic status, including the monitoring of body weight and food intake, fasting biochemistry, body composition (iDXA), cardiovascular parameters and glucose tolerance. After a metabolic challenge (high fat diet in males and gestation in females), animals were euthanized for postmortem phenotyping.

Sex-specific responses to maternal exposure were observed in adult offspring. Age-related increases in blood pressure (p=0.058), glycaemia (p=0.029), and perirenal fat mass (p=0.026) as well as reductions in HDL-cholesterol (p=0.025) and fat-to-body weight ratio (p=0.011) were observed in exposed males, suggesting a metabolic syndrome. Almost only trends were observed in exposed females with higher triglycerides and decreased bone density compared to control females. Metabolic challenges triggered or amplified some biological responses, especially in females.

In utero exposure to air pollution predisposed rabbit offspring to cardiometabolic disorders in a sex-specific manner.

In utero exposure to air pollution predisposed rabbit offspring to cardiometabolic disorders in a sex-specific manner.Anatase TiO2 photocatalyst supported on [BMPP]2[2D-Mo18O56] (BMPP = 1, 3-bis(4-methylpyridine) propane dibromide) was successfully prepared by hydrothermal method. The composites were characterized by field emission scanning electron microscopy (SEM), X-ray diffractometer (XRD), infrared spectroscopy (IR) and energy-dispersive X-ray spectrometer (EDS). The results show that the high content anatase nanoparticles are uniformly loaded on the polyacid supramolecules to form the composite material. The photocatalytic activity of TiO2/Mo9O28-BMPP towards the tetracyclines (TCs), a model pollutant, has been investigated. The results show that under a 500W high-pressure xenon lamp, 0.15 g TiO2/MoB can degrade 97% of 20 mL (25 mg/L) Tc after 115 min, showing high catalytic activity. In addition, 0.15-TiO2/MoB can be easily separated from the reaction system by centrifugation, and the catalyst still maintains high photocatalytic activity after 3 cycles of tests under the same conditions. This shows that it has the potential for recycling. This research provides a new way for the development of new supported catalysts.On January 30, 2020, COVID-19 outbreak, detected for the first time in Wuhan (China), was declared by WHO a Public Health Emergency. In a strongly connected world, the consequent slowdown of the Chinese economy contributed to disrupt the global supply chains of several products. In a post-pandemic scenario, the expected rapid increase in demand of critical raw materials (associated with the transition to more green energy sources), coupled with the problems that some mining activities are relegated only in certain countries and regions, must be considered in a sustainable perspective. This work analyses the literature about (critical) raw materials and COVID-19, not only to present the impact of the pandemic on their supply, but also to propose some actions that should be pursued in a post-pandemic renaissance scenario, to increase raw materials availability, with great attention to most critical ones, in the frame of circular economy principles. The post-pandemic possibilities are evaluated and suitable actions are suggested to secure the raw materials availability for the foreseen increase of investments in crucial and strategic sectors, in accord with the UN Sustainable Development Goals (SDGs). The proposed actions can be summarized as policy, strategy, economy, and technology activities.Invasive species, disease vectors, and pathogens are significant threats to biodiversity, ecosystem function and services, and human health. Understanding the optimal management strategy, which maximizes the effectiveness is crucial. Despite an abundance of theoretical work has conducted on projecting the optimal allocation strategy, almost no empirical work has been performed to validate the theory. We first used a consumer-resource model to simulate a series of allocation fractions of controlling treatment to determine the optimal controlling strategy. Further, we conducted rigorous laboratory experiments using spatially diffusing laboratory populations of yeast to verify our mathematical results. We found consistent results that (1) When population growth is limited by the local resource, the controlling priority should be given to the areas with higher concentration of resource; (2) When population growth is not limited by the resource concentration, the best strategy is to allocate equal amount of controlling efforts among the regions; (3) With restricted budget, it is more efficient to prioritize the controlling effects to the areas with high population abundance, otherwise, it is better to control equally among the regions. The new theory, which was tested by laboratory experiments, will reveal new opportunities for future field interventions, thereby informing subsequent biological decision-making.Studying the dynamical behaviors of neuronal models may help in better understanding of real nervous system. In addition, it can help researchers to understand some specific phenomena in neuronal system. The thalamocortical network is made of neurons in the thalamus and cortex. In it, the memory function is consolidated in sleep by creating up and down state oscillations (1 Hz) and fast (13-17 Hz) - slow (8-12 Hz) spindles. Recently, a nonlinear biological model for up-down oscillations and fast-slow spindles of the thalamocortical network has been proposed. In this research, the power spectral for the fast-slow spindle of the model is extracted. Dynamical properties of the model, such as the bifurcation diagrams, and attractors are investigated. The results show that the variation of the synaptic power between the excitatory neurons of the cortex and the reticular neurons in the thalamus changes the spindles' activity. According to previous experimental findings, it is an essential rule for consolidating the memory function during sleep. It is also pointed out that when the fast-slow spindles of the brain increase, the dynamics of the thalamocortical system tend to chaos.Colorectal cancer (CRC) as a lethal malignancy has been associated with dysregulation of several genes and pathways. Long noncoding RNAs (lncRNAs) play an important role in gene expression regulation. In the current research, we aim to evaluate the expression of LINC00978 in CRC samples and adjacent tissues. Using Quantitative Real-Time PCR (qRT-PCR) method, we assessed the expression levels of LINC00978 and β-catenin in 70 pairs of CRC and adjacent tissues. Moreover, the association between clinicopathological features and the LINC00978 expression levels was investigated. SIS17 cost To assess the diagnostic power of LINC00978 expression in CRC, receiver operating characteristic (ROC) curve was plotted. The relationship between LINC00978 and β-catenin expression levels was evaluated using correlation analysis. A markedly increased level of LINC00978 and β-catenin expression levels was observed in CRC samples compared with adjacent tissues (P less then 0.0001). No significant association was detected between LINC00978 expression level and the patient's clinicopathological features. The results of Pearson's correlation coefficient highlighted a positive correlation between LINC00978 and β-catenin expression (r2 = 0.4695, P less then 0.0001). According to the area under curve (AUC) value, LINC00978 expression differentiates CRC samples from the adjacent tissues (AUC = 0.81, P less then 0.0001). The present results suggest that LINC00978 may play a critical role in CRC progression via Wnt pathway. The potential role of LINC00978 as a diagnostic biomarker needs to be further investigated in future studies.

Several studies have reported that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly infect endothelial cells, and endothelial dysfunction is often found in severe cases of coronavirus disease 2019 (COVID-19). To better understand the prognostic values of endothelial dysfunction in COVID-19-associated coagulopathy, we conducted a systematic review and meta-analysis to assess biomarkers of endothelial cells in patients with COVID-19.

A literature search was conducted on online databases for observational studies evaluating biomarkers of endothelial dysfunction and composite poor outcomes in COVID-19 patients.

A total of 1187 patients from 17 studies were included in this analysis. The estimated pooled means for von Willebrand Factor (VWF) antigen levels in COVID-19 patients was higher compared to healthy control (306.42 [95% confidence interval (CI) 291.37-321.48], p < 0.001; I

86%), with the highest VWF antigen levels was found in deceased COVID-19 patients (448.57 [95% CI 407.20-489.93], p < 0.001; I

0%). Meta-analysis showed that higher plasma levels of VWF antigen, tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 antigen (PAI-1) antigen, and soluble thrombomodulin (sTM) were associated with composite poor outcome in COVID-19 patients ([standardized mean difference (SMD) 0.74 [0.33-1.16], p < 0.001; I

80.4%], [SMD 0.55 [0.19-0.92], p = 0.003; I

6.4%], [SMD 0.33 [0.04-0.62], p = 0.025; I

7.9%], and [SMD 0.55 [0.10-0.99], p = 0.015; I

23.6%], respectively).

The estimated pooled means show increased levels of VWF antigen in COVID-19 patients. Several biomarkers of endothelial dysfunction, including VFW antigen, t-PA, PAI-1, and sTM, are significantly associated with increased composite poor outcomes in patients with COVID-19.

CRD42021228821.

CRD42021228821.