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43, and correlations were significant for iron, calcium, riboflavin, sodium, saturated fat, niacin, and vitamin C. The energy-adjusted and de-attenuated ICCs ranged from 0.01 to 0.31, and the weighted Kappa ranged from 0.01 to 0.46. The analyses of agreement were significant for vitamin C, fiber, calcium, riboflavin, niacin, sodium, lipids, and iron. In conclusion, the FFQ presented acceptable relative validity for lipids, saturated fatty acids, fiber, calcium, iron, riboflavin, niacin, vitamin C, and sodium. This instrument will be useful in studies about food consumption of adolescents in São Luís, Maranhão.Fetuses exposed to alcohol and/or tobacco are at risk for perinatal adversities. However, little is currently known about the association of the separate or concomitant use of alcohol and tobacco with infant motor and cognitive development. Thus, the objective of the present study was to investigate the association between maternal consumption of alcohol and/or tobacco during pregnancy and the motor and cognitive development of children starting from the second year of life. The study included 1006 children of a cohort started during the prenatal period (22-25 weeks of pregnancy), evaluated at birth and reevaluated during the second year of life in 2011/2013. The children were divided into four groups according to the alcohol and/or tobacco consumption reported by their mothers at childbirth no consumption (NC), separate alcohol consumption (AC), separate tobacco consumption (TC), and concomitant use of both (ACTC). The Bayley Scale of Infant and Toddler Development Third Edition screening tool was used for the assessment of motor and cognitive development. Adjusted Poisson regression models were used to determine the association between groups and delayed development. The results indicated that only the ACTC group showed a higher risk of motor delay, specifically regarding fine motor skills, compared to the NC group (RR=2.81; 95%CI 1.65; 4.77). Separate alcohol or tobacco consumption was not associated with delayed gross motor or cognitive development. However, the concomitant use of the two substances increased the risk of delayed acquisition of fine motor skills.A prospective cohort study was conducted on a convenience sample of 1370 pregnant women with a gestational age of 20 to 25 weeks in the city of Ribeirão Preto. Data on obstetrical history, maternal age, parity, smoking habit, and a history of preterm delivery was collected with the application of a sociodemographic questionnaire. Cervical length was determined by endovaginal ultrasound, and urine and vaginal content samples were obtained to determine urinary tract infection (UTI) and bacterial vaginosis (BV), respectively. The aim of this study was to verify the association of cervical length and genitourinary infections with preterm birth (PTB). Ultrasound showed no association of UTI or BV with short cervical length. PTB rate was 9.63%. Among the women with PTB, 15 showed UTI (RR 1.55, 95%CI 0.93-2.58), 19 had BV (RR 1.22, 95%CI 0.77-1.94), and one had both UTI and BV (RR 0.85, 95%CI 0.13-5.62). Nintedanib order Nineteen (14.4%) PTB occurred in women with a cervical length ≤2.5 cm (RR 2.89, 95%CI 1.89-4.43). Among the 75 patients with PTB stratified as spontaneous, 10 showed UTI (RR 2.02, 95%CI 1.05-3.86) and 14 had a diagnosis of BV (RR 1.72, 95%CI 0.97-3.04). A short cervical length between 20 and 25 weeks of pregnancy was associated with PTB, whereas UTI and BV determined at this age were not associated with short cervical length or with PTB, although UTI, even if asymptomatic, was related to spontaneous PTB.Successful applications of photodynamic therapy (PDT) in cancer treatment require the development of effective photosensitizers with controllable singlet oxygen generation. Here we report a ubiquinone-BODIPY photosensitizer that self-assembles into nanoparticles (PS-Q-NPs) and undergoes selective activation and deaggregation within the highly reductive intracellular environment of tumor cells. PS-Q-NPs are highly stable in aqueous buffer solution, and exhibit minimal fluorescence and photosensitization due to a rapid non-radiative relaxation process. Upon endocytosis by cancer cells, reduction of the ubiquinone moiety by intracellular glutathione (GSH) triggers the conversion of the aggregated hydrophobic precursor into the active hydrophilic carboxylate derivative PS-A. The conversion results in enhanced fluorescence and therapeutic singlet oxygen generation, portending to its application as an activatable photosensitizer for fluorescence imaging-guided photodynamic cancer therapy.The generation of long-lived charge transfer (CT) states in electron donor/acceptor dyads upon photoexcitation is crucial for artificial photosynthesis, photocatalysis and photovoltaics. Electron spin control is a novel strategy to prolong the CT state lifetime via generation of the 3CT triplet state, instead of the traditional short-lived 1CT state. This method involves a local triplet excited state (3LE) as the precursor of charge separation (CS), and the electron forbidden feature of the charge recombination (CR) of 3CT → S0vs. the electron spin allowed 1CT → S0 prolongs the CT state lifetime. In this article, we summarized the recent developments and challenges in this emerging fascinating area.Endometrial cancer (EC) is a malignancy that severely threatens women's health and there is an urgent need to find novel natural compounds as effective treatment drugs. At the same time, multi-omics analysis of cells has been widely used in basic research to find new pathogenesis and mechanisms. Due to the lack of data on the functional importance of mRNAs and miRNAs in plant-derived asparanin A (AA) induced cancer cells, the underlying mechanisms of AA on endometrial cancer (EC) Ishikawa cells were investigated using mRNA-seq and miRNA-seq, qRT-PCR, western blot, and immunohistochemistry. The combined analysis of 37 differentially expressed miRNAs (DEMs) and 489 differentially expressed genes (DEGs) with negative regulatory relationships revealed that AA not only induced apoptosis, but also triggered autophagy through endoplasmic reticulum (ER) stress and DNA damage-related pathways. 23 DEMs and 39 DEGs participated in protein processing in the endoplasmic reticulum (PPER) and p53 signaling pathways, as shown by miRNA-target gene network analyses.