Juulkang4680

9 vs -1.7 points, p = 0.03) or <50 % reduction in CPD (n = 57) (-2.9 vs -1.1 points, p < 0.01). The mean reduction in AUDIT-C did not differ between a ≥50 % reduction and <50 % reduction in CPD (-1.7 vs.-1.1 points, p = 0.18). Mean reductions in days of HED and the PHQ-2 did not differ according to the level of reduction in CPD.

Smoking reduction was associated with reductions in alcohol consumption and depressive symptoms. Reductions appeared to be greater for those who achieved abstinence compared to a reduction in smoking.

Smoking reduction was associated with reductions in alcohol consumption and depressive symptoms. Reductions appeared to be greater for those who achieved abstinence compared to a reduction in smoking.Coca paste is the most popular form of smoked cocaine (SC) in Latin America and also the most widespread among adolescents in vulnerable sectors of society, thus representing a significant public health concern. Despite evidence suggesting that abnormal executive-attention function is predictive of addiction to stimulant drugs, no study to date has compared clinically relevant neuropsychological (NPS) and physiological variables between individuals with histories of smoked cocaine dependence (SCD) and insufflated cocaine hydrochloride dependence (ICD). In this study we evaluated 25 SCD and 22 ICD subjects matched by poly-consumption profiles, and 25 healthy controls (CTR) matched by age, gender, education, and socioeconomic status. An exhaustive NPS battery was used to assess cognitive domains (attention, executive functions, fluid intelligence, memory, language and social cognition). We complemented this assessment with structural (MRI) and functional (fMRI) neuroimaging data. We found that executive function and attention impairments could be explained by the administration route of cocaine, with strongest impairments for the SCD group. SCD also presented reduced grey matter density relative to ICD and CTR in the bilateral caudate, a key area for executive and attentional function. Functional connectivity between left caudate and inferior frontal regions mediated the association between brain structure and behavioral performance. Our results highlight the relevance of assessing the route of administration of stimulants, both in clinical and research settings.Infiltration between the popliteal artery and capsule of the knee (iPACK) block is an emerging modality to control perioperative knee joint pain. This case report describes the successful control of chronic knee joint pain using iPACK block in a patient with knee osteoarthritis. SHP099 inhibitor We suggest that iPACK block could be applied in the fields of both pain medicine and perioperative analgesia. In addition, by placing the needle closely to the popliteal plexus, iPACK block could serve as an intervention for pain related to procedures such as radiofrequency ablation.

Cancers of unknown primary (CUPs) are tumors found after metastasizing from unidentified primary sites; these tumors generally have unknown treatment strategies, expected treatment results, and prognosis. We assessed the epidemiological characteristics of CUPs in Korea.

We extracted records for 1999 through 2017 from the Korea Central Cancer Registry using the International Statistical Classification of Diseases and Related Health Problems (10th revision) codes for CUP as defined by the International Agency for Research on Cancer. Age-standardized rates and relative survival rates were calculated.

The CUPs constituted 2.1 % of the total number of cancer registrations in 1999, declining to 0.7 % in 2017. The incidence rate decreased for both sexes (5.35 to 2.20 for men, 3.15 to 1.77 for women). Patients aged 80 years and older had the highest incidence rate at 40.2, and 86.3 % of CUPs occurred in those 50 years of age or older. The cases of retroperitoneum and peritoneum sites increased over time. Cases diagnosed by microscopic methods and death certification only were 62.3 % and 7.9 %, respectively. The malignant neoplasm of the retroperitoneum and peritoneum and unknown primary site had the highest and lowest survival rates, respectively. The 5-year relative survival rate increased over time from 14.2 % (1999-2002) to 27.3 % (2013-2017).

Our analysis of data from the Korea Central Cancer Registry found decreasing rates of CUP, although with consistent disparities by patient age and sex. Advancements in diagnostic technology may be decreasing the number of CUP diagnoses. Expanding the amount of information recorded in the registry may further improve diagnostic accuracy.

Our analysis of data from the Korea Central Cancer Registry found decreasing rates of CUP, although with consistent disparities by patient age and sex. Advancements in diagnostic technology may be decreasing the number of CUP diagnoses. Expanding the amount of information recorded in the registry may further improve diagnostic accuracy.

Intermediate risk (IR) prostate cancer (PCa) is a highly heterogeneous entity and can be distinguished into favorable and unfavorable IR PCa according to biopsy, PSA and cT-stage characteristics. These differences may translate into differences in treatment type.

We tested for differences in PCa tumor characteristics and differences in active treatment rates (radical prostatectomy [RP], external beam radiotherapy [EBRT]) according to Surveillance, Epidemiology and End Results (SEER) registry (2010-2015) in favorable and unfavorable IR PCa. Data were stratified according to individual SEER registries. Further analyses additionally adjusted for PCa baseline characteristics (PSA, cT stage, biopsy Gleason group grading [GGG], percentage of positive biopsy cores).

Tabulations according to SEER registries showed that, in favorable IR vs. unfavorable IR, the rates of RP and EBRT respectively ranged from 30.0 to 54.3% vs. 30.3-55.5 % and 8.3-44.7 % vs. 11.5-45.5 %. Differences in age and baseline PCa tumor characteristics also existed in both favorable and unfavorable IR across SEER registries. After adjustment for those baseline patient and PCa characteristics (PSA, cT stage, GGG, percentage of positive biopsy cores), RP and EBRT rates exhibited virtually no residual differences across individual SEER registries, in both favorable (36.0-41.0 % and 26.8-28.1 %) and unfavorable IR PCa (39.2-42.0% and 31.1-33.5 %).

Important differences may be identified in treatment rates within the examined 18 SEER registries in favorable and in unfavorable IR PCa. However, the observed differences are virtually entirely explained by differences in baseline PCa characteristics.

Important differences may be identified in treatment rates within the examined 18 SEER registries in favorable and in unfavorable IR PCa. However, the observed differences are virtually entirely explained by differences in baseline PCa characteristics.Neck muscle size and strength have been linked to lower injury risk and reduced pain. However, prior findings have been inconclusive and have failed to clarify whether there are sex differences in neck muscle size-strength relationships. link2 Such differences may point to an underlying cause for the reported sex difference in neck pain prevalence. Thirty participants (13 males, 17 females) who underwent neck strength testing and MR imaging were analyzed. Strength was measured in three conditions that differed in posture and exertion direction. Muscle size was quantified by three metrics anatomical cross-sectional area (ACSA), muscle volume (MV), and an estimate of physiological cross-sectional area-reconstruction-based cross-sectional area (RCSA). Inter-posture strength correlations, muscle size-strength correlations, and sex differences were analyzed with linear regression. Males were approximately 65% stronger and had significantly larger muscles. Strength varied significantly across postures, but only female strength values for different postures were significantly correlated. Observed in males only, the sternocleidomastoid (SCM) was a strong predictor of flexion strength in the neutral posture while the anterior scalene (AS) was more involved in the extended. No extensor's size was significantly linked to extension strength. A greater amount of force variation is unexplained by muscle size alone in females than in males. Males and females exhibited distinct size-strength relationships, highlighting the need for sex-specific models and analyses and the greater potential effect of non-morphometric factors on force generating capacity in females. link3 No advantage of one muscle size metric over another in strength prediction was evidenced.Anellovirus infections are highly prevalent in mammals, however, prior to this study only a handful of anellovirus genomes had been identified in members of the Felidae family. Here we characterise anelloviruses in pumas (Puma concolor), bobcats (Lynx rufus), Canada lynx (Lynx canadensis), caracals (Caracal caracal) and domestic cats (Felis catus). The complete anellovirus genomes (n = 220) recovered from 149 individuals were diverse. ORF1 protein sequence similarity network analysis coupled with phylogenetic analysis, revealed two distinct clusters that are populated by felid-derived anellovirus sequences, a pattern mirroring that observed for the porcine anelloviruses. Of the two-felid dominant anellovirus groups, one includes sequences from bobcats, pumas, domestic cats and an ocelot, and the other includes sequences from caracals, Canada lynx, domestic cats and pumas. Coinfections of diverse anelloviruses appear to be common among the felids. Evidence of recombination, both within and between felid-specific anellovirus groups, supports a long coevolution history between host and virus.

One of the significant retinal diseases that affected older people is called Age-related Macular Degeneration (AMD). The first stage creates a blur effect on vision and later leads to central vision loss. Most people overlooked the primary stage blurring and converted it into an advanced stage. There is no proper treatment to cure the disease. So the early detection of AMD is essential to prevent its extension into the advanced stage. This paper proposes a novel deep Convolutional Neural Network (CNN) architecture to automate AMD diagnosis early from Optical Coherence Tomographic (OCT) images.

The proposed architecture is a multiscale and multipath CNN with six convolutional layers. The multiscale convolution layer permits the network to produce many local structures with various filter dimensions. The multipath feature extraction permits CNN to merge more features regarding the sparse local and fine global structures. The performance of the proposed architecture is evaluated through ten-fold cross-validacture. Comparison with other approaches produced results that exhibit the efficiency of the proposed algorithm in the detection of AMD. The proposed architecture can be applied in rapid screening of the eye for the early detection of AMD. Due to less complexity and fewer learnable parameters.

We present a Health Care System (HCS) based on integrated learning to achieve high-efficiency and high-precision integration of medical and health big data, and compared it with an internet-based integrated system.

The method proposed in this paper adopts the Bagging integrated learning method and the Extreme Learning Machine (ELM) prediction model to obtain a high-precision strong learning model. In order to verify the integration efficiency of the system, we compare it with the Internet-based health big data integration system in terms of integration volume, integration efficiency, and storage space capacity.

The HCS based on integrated learning relies on the Internet in terms of integration volume, integration efficiency, and storage space capacity. The amount of integration is proportional to the time and the integration time is between 170-450ms, which is only half of the comparison system; whereby the storage space capacity reaches 8.3×2

TB.

The experimental results show that the integrated learning-based HCS integrates medical and health big data with high integration volume and integration efficiency, and has high space storage capacity and concurrent data processing performance.