Jorgensenpersson4740
From various studies on insect radiation resistance and after phylogenetic analysis of insect species it appears that the evolutionary near species have drastically different levels of radio-resistance and trait of radiation resistance appears to be independent of insect evolution.
Environment and lifestyle factors are being attributed toward increased instances of male infertility. Rapid technological advancement, results in emission of electromagnetic radiations of different frequency which impacts human both biologically as well as genetically. Devices like cell phone, power line and monitors emit electromagnetic radiation and are a major source of the exposure. Numerous studies describe the detrimental consequence of radiation on physiological parameters of male reproductive system including sperm parameters (morphology, motility, and viability), metabolism and genomic instability. While the thermal and nonthermal interaction of nonionizing radiations with biological tissues can't be ruled out, most studies emphasize the generation of reactive oxygen species. Oxidative stress alters redox equilibrium and disrupts morphology and normal functioning of sperms along with declination of total anti-oxidant capacity.
In this paper, we describe a detailed literature review with the intent of analyzing the impact of electromagnetic radiation and understand the consequence on male reproductive system. AZD3229 The underlying mechanism suggesting ROS generation and pathway of action has also been discussed. Additionally, the safety measures while using electronic gadgets and mobile phones has also been presented.
In this paper, we describe a detailed literature review with the intent of analyzing the impact of electromagnetic radiation and understand the consequence on male reproductive system. The underlying mechanism suggesting ROS generation and pathway of action has also been discussed. Additionally, the safety measures while using electronic gadgets and mobile phones has also been presented.
Recent evidence suggests that transcriptional reprogramming is involved in the pathogenesis of cardiac remodeling (cardiomyocyte hypertrophy and fibrosis) and the development of heart failure. 5-Azacytidine (5aza), an inhibitor of DNA methylation approved for hematological malignancies, has previously demonstrated beneficial effects on cardiac remodeling in hypertension. The aim of our work was to investigate whether pressure overload is associated with alterations in DNA methylation and if intervention with low-dose 5aza can attenuate the associated pathological changes.
C57Bl6/J mice underwent surgical constriction of the aortic arch for 8 weeks. Mice began treatment 4 weeks post-surgery with either vehicle or 5aza (5 mg/kg). Cardiac structure and function was examined
using echocardiography followed by post mortem histological assessment of hypertrophy and fibrosis. Global DNA methylation was examined by immunostaining for 5-methylcytosine (5MeC) and assessment of DNA methyltransferase expression. Tenuated myocardial hypertrophy and fibrosis. Our work supports the rationale for its potential use in cardiac pathologies associated with aberrant cardiac wound healing.Drug metabolizing enzymes catalyze the biotransformation of many of drugs and chemicals. The drug metabolizing enzymes are distributed among several evolutionary families and catalyze a range of detoxication reactions, including oxidation/reduction, conjugative, and hydrolytic reactions that serve to detoxify potentially toxic compounds. This detoxication function requires that drug metabolizing enzymes exhibit substrate promiscuity. In addition to their catalytic functions, many drug metabolizing enzymes possess functions unrelated to or in addition to catalysis. Such proteins are termed 'moonlighting proteins' and are defined as proteins with multiple biochemical or biophysical functions that reside in a single protein. This review discusses the diverse moonlighting functions of drug metabolizing enzymes and the roles they play in physiological functions relating to reproduction, vision, cell signaling, cancer, and transport. Further research will likely reveal new examples of moonlighting functions of drug metabolizing enzymes.Interventional Radiology (IR) medicine's best kept secret will revolutionise healthcare like never before. The legacy Charles Dotter left behind not only showcases IR's pursuit of innovative and complex techniques in order to provide better treatment options for patients, it also sparked an opportunity for radiologists to use their imagination and creativity to develop IR into a speciality catering for the 21st century. By utilising imaging as well as clinical and minimal invasive surgical knowledge IRs are able to play an integral role in caring for patients in nearly all specialities.Over the past few decades, the absence of radiology in the leadership management arena has allowed other specialities to perpetuate turf wars and utilise techniques developed by IR. A concerted effort is required by the wider radiology community to address the problems faced by IR and to recognise its true potential as a speciality to further improve patient care.
To evaluate the wide-field fundus fluorescein angiography (WFA) characteristics of uveitis associated with juvenile idiopathic arthritis (JIA-uveitis).
Retrospective review of records. WFA with Spectralis (Heidelberg) of JIA-uveitis patients were analyzed using the scoring system by Angiography Scoring for Uveitis Nomenclature.
Thirty-seven eyes of 20 patients were studied. A total score of at least 1 was noted in 27 eyes (72.97%). WFA features included optic disc hyperfluorescence (51.35%), macular leakage (27.03%), retinal vascular staining/leakage at posterior pole (27.03%) and peripheral retina (64.86%), capillary leakage at the posterior pole (37.84%), and peripheral retina (59.46%). A decision to change the management plan was made in 8 of 9 patients with bilateral quiet anterior chambers after WFA results.
More than 70% of JIA-uveitis eyes showed some WFA-evidence of posterior segment inflammation, which changed the course of therapy for a major proportion of patients with no clinically active anterior chamber inflammation.
