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Moyamoya angiopathy (MA) is a progressive cerebrovascular disease with a poorly understood pathophysiology. It is mainly characterized by progressive bilateral stenosis of the terminal intracranial part of the supraclinoid internal carotid arteries and the proximal parts of the middle and anterior cerebral arteries. This results in early-onset ischemic or hemorrhagic strokes. The disease may be idiopathic (known as Moyamoya disease) or associated with other heritable or acquired conditions, including type 1 neurofibromatosis or other RASopathies, sickle cell disease, Down syndrome, or autoimmune disorders (known as Moyamoya syndrome). Apart from the brain, other organ manifestations including cutaneous ones have also been described in MA patients.

A literature research on PubMed was performed for articles mentioning the cutaneous association in MA and published between 1994 and October 2020.

The present review summarizes the cutaneous associations as well as the coincidental dermatological findings seen in MA patients. Those include changes in the epidermis, dermis, or skin appendages for example café-au-lait spots, hypomelanosis of Ito, livedo racemosa, hemangiomas, premature graying of hair, chilblains etc.

The present review summarizes the cutaneous associations as well as the coincidental dermatological findings seen in MA patients. Those include changes in the epidermis, dermis, or skin appendages for example café-au-lait spots, hypomelanosis of Ito, livedo racemosa, hemangiomas, premature graying of hair, chilblains etc.

There are an increasing number of studies that discussed suicide ideation (SI), suicide plan (SP), and suicide attempt (SA) among left-behind children (LBC). However, the prevalence of these indicators of LBC has not been synthesized and the true correlation between these indicators and left-behind status remains unclear.

Electronic databases were comprehensively searched, and eligible observational studies were selected to extract useful data. We pooled the rates and their 95% confidence intervals (95% CIs) to determine the prevalence of SI, SP, and SA among LBC. The odds ratios (ORs) and 95% CIs were calculated to reflect the association between left-behind status and risk of SI, SP, and SA.

Among LBC, the pooled prevalence was 18.7% (95% CI 15.4-21.9) for SI, 6.4% (95% CI 4.7-8.1) for SP, and 3.1% (95% CI 2.6-3.6) for SA. Compared to non-LBC, LBC was at higher risk of SI (OR=1.26), SP (OR=1.20), and SA (OR=1.14), but only the effect for SI achieved statistical significance.

Overall, the prevalence of SI, SP, and SA is common among LBC, and parental migration has a significant impact on the SI of LBC. Intervention plans and programs are urgently needed to prevent suicidality of this vulnerable group.

Overall, the prevalence of SI, SP, and SA is common among LBC, and parental migration has a significant impact on the SI of LBC. Retinoic acid price Intervention plans and programs are urgently needed to prevent suicidality of this vulnerable group.

What is the central question of this study? The extent to which genetics determines adaptation to endurance versus resistance exercise is unclear. Previously, a divergent selective breeding rat model showed that genetic factors play a major role in the response to aerobic training. Here, we asked do genetic factors that underpin poor adaptation to endurance training affect adaptation to functional overload? What is the main finding and its importance? Our data show that heritable factors in low responders to endurance training generated differential gene expression that was associated with impaired skeletal muscle hypertrophy. A maladaptive genotype to endurance exercise appears to dysregulate biological processes responsible for mediating exercise adaptation, irrespective of the mode of contraction stimulus.

Divergent skeletal muscle phenotypes result from chronic resistance-type versus endurance-type contraction, reflecting the principle of training specificity. Our aim was to determine whether there isr compensatory hypertrophy, and attenuated hypertrophy was associated with differential gene set regulation. Our findings suggest that genetic factors that underpin aerobic training maladaptation might also dysregulate the transcriptional regulation of biological processes that contribute to adaptation to mechanical overload.

Soil acidity causes an increase in the solubility of toxic aluminium (Al), inhibiting root growth and limiting plant access to soil water and nutrients. Toxicity of Al decreases growth and development more in Al-sensitive than Al-resistant wheat (Triticum aestivum L.) genotypes. Applying magnesium (Mg) may alleviate Al toxicity in acidic soil. It is unclear if growing Al-resistant wheat, coupled with Mg application, will enhance wheat growth and physiological responses in acidic soil. Wheat was grown in the reconstituted acidic soil profile in a three-factor glasshouse experiment comprising foliar Mg at [Mg] = 0 and 200 mg L

(using magnesium sulfate), wheat genotypes ES8 (Al sensitive) and ET8 (Al resistant), and four soil treatments [non-amended soil (pH

   4.0); 100% of the recommended lime dose in subsoil to raise pH to 6.0; or 20 mg Mg kg

soil to the whole soil profile (as magnesium sulfate or magnesium chloride)].

Applying foliar Mg to Al-resistant wheat significantly increased shoot dry weight (24%), subsoil root dry weight (12%), subsoil coarse (>0.2 mm in diameter) root length (12%), net photosynthetic rate (28%), and total leaf area (10%) compared with plants not treated with foliar Mg. Combining foliar Mg application with subsoil liming increased the subsoil total root length by 1.3-fold compared with zero foliar Mg. Without foliar Mg, subsoil liming and soil Mg amendment significantly (by 10%) enhanced shoot growth and total leaf area compared with non-amended soil.

Growing an Al-resistant genotype coupled with applying Mg foliarly and to soil improved wheat growth in an acidic soil. © 2021 Society of Chemical Industry.

Growing an Al-resistant genotype coupled with applying Mg foliarly and to soil improved wheat growth in an acidic soil. © 2021 Society of Chemical Industry.