Johnsgarza6789

Zwitterionic polymers are classical antifouling polymers but they require specialized monomers that have cationic and anionic charges integrated into a single monomer. Herein, we show that pseudo-zwitterionic copolymers synthesized from a mixture of 2 monomers each having a single opposite polarity has excellent antibiofilm efficacy. We have discovered a new mixed-charge copolymer brush (#1-A) synthesized from 2 oppositely charged monomers, the anionic SPM (3-Sulfopropyl methacrylate) and the cationic AMPTMA ((3-Acrylamidopropyl) trimethylammonium chloride), that achieves broad spectrum in vitro antibiofilm effect of greater than 99% reductions against all six Gram-positive and Gram-negative bacteria tested. In the murine subcutaneous wound catheter infection models, the #1-A has good long-term anti-biofilm efficacy against MRSA and Pseudomonas aeruginosa of 3.41 and 3.19 orders respectively, outperforming previous mixed-charge copolymer coatings. We discovered a new method to choose the cationic/anionic pair combination to form the best antibiofilm copolymer brush coating by exploiting the solution polymerization kinetics disparity between the cationic and anionic monomers. We also showed that #1-A is softer and has higher hydration than the classical zwitterionic polymer. This study shows the possibility of achieving potent antibiofilm efficacy by combining readily available opposite singly charged monomers.Limitations in laboratory diagnostic capacity and reporting delays have hampered efforts to mitigate and control the ongoing coronavirus disease 2019 (COVID-19) pandemic globally. To augment traditional lab and hospital-based surveillance, Bangladesh established a participatory surveillance system for the public to self-report symptoms consistent with COVID-19 through multiple channels. Here, we report on the use of this system, which received over 3 million responses within two months, for tracking the COVID-19 outbreak in Bangladesh. Although we observe considerable noise in the data and initial volatility in the use of the different reporting mechanisms, the self-reported syndromic data exhibits a strong association with lab-confirmed cases at a local scale. Moreover, the syndromic data also suggests an earlier spread of the outbreak across Bangladesh than is evident from the confirmed case counts, consistent with predicted spread of the outbreak based on population mobility data. Our results highlight the usefulness of participatory syndromic surveillance for mapping disease burden generally, and particularly during the initial phases of an emerging outbreak.Savannas are the most fire-prone of Earth's biomes and currently account for most global burned area and associated carbon emissions. In Australia, over recent decades substantial development of savanna burning emissions accounting methods has been undertaken to incentivise more conservative savanna fire management and reduce the extent and severity of late dry season wildfires. Since inception of Australia's formal regulated savanna burning market in 2012, today 25% of the 1.2M km2 fire-prone northern savanna region is managed under such arrangements. Although savanna burning projects generate significant emissions reductions and associated financial benefits especially for Indigenous landowners, various biodiversity conservation considerations, including fine-scale management requirements for conservation of fire-vulnerable taxa, remain contentious. For the entire savanna burning region, here we compare outcomes achieved at 'with-project' vs 'non-project' sites over the period 2000-19, with respect to explicit ecologically defined fire regime metrics, and assembled fire history and spatial mapping coverages. We find that there has been little significant fire regime change at non-project sites, whereas, at with-project sites under all land uses, from 2013 there has been significant reduction in late season wildfire, increase in prescribed early season mitigation burning and patchiness metrics, and seasonally variable changes in extent of unburnt (>2, >5 years) habitat. Despite these achievements, it is acknowledged that savanna burning projects do not provide a fire management panacea for a variety of key regional conservation, production, and cultural management issues. Rather, savanna burning projects can provide an effective operational funded framework to assist with delivering various landscape-scale management objectives. With these caveats in mind, significant potential exists for implementing incentivised fire management approaches in other fire-prone international savanna settings.Miombo woodlands sustainability in east and south-central Africa is threatened by human activities, including overgrazing. This study investigated seasonal variations in rangeland condition in three grazed areas in miombo woodlands in eastern Tanzania. Transect lines were established across the grazing areas, sampling points were identified and marked at every 10% of the length of transect line. Sampling points were categorised in different distances with respect to settlement. The line intercept method was used to collect data on vegetation cover and forage distribution, while herbaceous forage biomass was estimated using a disc pasture meter. HO-3867 cell line A total of 118 different plant species were observed and grasses comprised 40.6% of all herbaceous species. Bothriochloa pertusa, Cynodon plectostachyus, Hyparrhenia rufa and Urochloa mosambicensis grass species dominated miombo grazed areas in various seasons and distances. These perennial grass species are desirable and indicated moderate grazing activities in miombo. Season affected grass cover, herbaceous forage biomass and nutritional composition. Grass cover and forage biomass were at the lowest during late dry season while forage nutritional quality was best during early dry season. Distance from settlement had no effect on grass cover and herbaceous forage biomass. Rangeland condition was generally fair, livestock stocking rate in continuously grazed drylands should be set at the lowest monthly forage biomass in order to ensure grazing land sustainability.