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These factors have been known targets for many anticancer drugs and treatments, and their modulation is a therapeutic goal, with the hope of rendering solid cancer a chronic rather than deadly disease. In this article, the current therapeutic arsenal against cancers is reviewed with a focus on immunotherapies.Realtors match home-seekers with neighborhoods that have built and social characteristics they desire to pursue active lifestyles. Studies have yet to explore realtors' perspectives on neighborhood design that supports active living. Using qualitative description, our study was to explore the perceptions and understandings of neighborhood design (walkability, healthy, bike-ability, vibrancy, and livability) among urban residential realtors. Nineteen (6 men; 13 women; average age 48 years) self-identified residential realtors from Calgary, Edmonton, and Lethbridge (Canada) completed semi-structured telephone interviews. Content analysis identified themes from the interview data. Specifically, walkability was described as perceived preferences, destinations and amenities, and connections; a healthy community was described as encourages outdoor activities, and promotes social homogeneity; bike-ability was described as bike-ability attributes, and was controversial; vibrancy was described as community feel, and evidence of life; and livability was described as subjective, and preferences and necessities. Our findings can inform the refinement of universal definitions and concepts used to in neighborhood urban design.The determinants of children's independent school mobility and the contextual discrepancies between these determinants have not been comprehensively investigated in previous studies. It is important to examine these determinants because independent school mobility is associated with children's physical activity, according to the literature. This paper examined the associations of different groups of variables such as household, mobility, perceptions, and the built environment with independent school mobility of children between 9 and 12 years using a sample of 1304 girls (50.9%) and boys (49.1%) in seven European countries. The sample was analyzed by Multinomial Logistic Regression, Chi-square test of independence, and Proportional Reduction in Error methods. According to the findings, father's and mother's commute mode choice, child's mode choice of commute to school, child's bike ownership, parent's perception of safety, parent's evaluation of bike lane and sidewalk quality, child's commute distance, number of driving licenses in the household, accessibility of public transport, and population density in the neighborhood and around the school proved to be very strong and significant determinants of children's independent school mobility in the Europe-wide sample. The comparison of the levels of independent school mobility did not show any significant differences between high-income countries such as Germany, Italy, and the Netherlands, and emerging economies and developing countries like Poland, Greece, Turkey, and Croatia. However, a direct comparison between Poland (emerging economy) (33.6%) and the Netherlands (high-income) (31.7%) revealed significant differences in the level of independent school mobility. This study found the motives for this discrepancy due to the significant difference in bike ownership, the number of household members working outside of the house, household size, commute distances of parents, and driving license possession.The early strength of magnesium phosphate cement (MPC) decreases sharply in severe cold environments ≤-10 °C, with the 2 h compressive strength falling to 3.5 MPa at-20 °C. Therefore, it cannot be used as a repair material for emergency repair construction in such environments. In this study, MPC is adapted for use in such cold environments by replacing part of the dead-burned magnesia (M) in the mixture with a small amount of light-burned magnesia (LBM) and introducing dilute phosphoric acid (PA) solution as the mixing water. The heat released by the highly active acid-base reaction of PA and LBM stimulates an MPC reaction. Selleckchem LAQ824 Moreover, the early strength of the MPC significantly improves with the increase in the Mg2+ concentration and the initial reaction temperature of the MPC paste, which enables MPC hardening in severe cold environments. Although the morphology of the reaction products of the MPC is poor and the grain plumpness and size of the struvite crystals are remarkably reduced, the early strength of MPC prepared in the severe cold environment is close to that of MPC prepared under normal temperature. Furthermore, the increases in the early reaction temperature and early strength of magnesium phosphate cement concrete (MPCC) are significantly improved when the PA concentration in the mixing water and the LBM/M ratio are 10% and 4-6% at -10 °C and 20% and 6-8% at -20 °C, respectively. Moreover, self-curing of MPCC can be realized even at -20 °C, at which temperature the 2 h and 24 h compressive strength of MPCC reach 36 MPa and 45 MPa, respectively.No studies have addressed the way the effectiveness of fear and hope advertisements differs across differently characterized individuals. The present study aims to find out in which situations related to different individual characteristics do fear and hope advertisements work as tools in generating healthy eating intention and physical activity intention. This study conducted an experiment using 283 adults from Chile. The results suggest that fear versus hope appeals in health advertisements have a more positive influence on healthy eating intention. The results suggest that the effect of fear advertisements on healthy eating intention is positively moderated by the frequency of fast food consumption and is negatively moderated by self-efficacy. The results suggest that fear versus hope appeals in health advertisements have no main effect on physical activity intention. However, the results suggest that the effect of fear advertisements on physical activity intention is positively moderated by perceived body weight and past healthy eating behavior and is negatively moderated by subjective norms. The results indicate that when making health advertising, homogenous messages are not persuasive for heterogeneous audiences. The present study results suggest that fear and hope advertisements should be delivered considering the individual characteristics identified in the present study.