Johansenlin1415

The diagnosis was changed in 25% of cases. In summary, we found an increasing time trend of false-negative smears taken before invasive cervical cancer. selleck inhibitor This indicates a decreased protection of normal cytology in the screening program supporting earlier findings that this is the main reason behind the recent Swedish increase in cervical cancer. We suggest that optimal cervical cancer control may be promoted by routine nationally coordinated rereview of negative smears before high-grade cervical lesions or invasive cervical cancer.

Complement deposition is prevalent in kidney biopsies of patients with arterial hypertension and hypertensive nephropathy, but an association of hypertension and complement deposition or involvement of complement in the pathogenesis of hypertensive nephropathy has not been shown to date.

In this study, we analyzed complement C1q and C3c deposition in a rat model of overload and hypertension by subtotal nephrectomy (SNX) and in archival human renal biopsies from 217 patients with known hypertension and 91 control patients with no history of hypertension using semiquantitative scoring of C1q and C3c immunohistochemistry and correlation with parameters of renal function. To address whether complement was only passively deposited or actively expressed by renal cells, C1q and C3 mRNA expression were additionally analyzed.

Glomerular C1q and C3c complement deposition were significantly higher in kidneys of hypertensive SNX rats and hypertensive compared to nonhypertensive patients. Mean arterial blood pressurrther studies are needed.This research presents new information about the nanoparticles (NPs) use as a filtrate reducer in the hydraulic fracturing of shale reservoirs. An experimental study was conducted to determine the filtration loss control effectiveness (FLCE) of CaCO3NPs as an additive in fluids used for hydraulic fracturing of the shale reservoirs. The main objectives were (i-) to determine the mechanisms controlling the NPs enhanced fracturing fluid leak-off rate; (ii-) to determine the optimum NPs concentration, which yields the best FLCE. Spontaneous and forced imbibition experiments (to determine imbibition index) as well as the pressure transmission tests (to determine liquid permeability) were conducted using water based fracturing fluids enhanced by CaCO3NPs. The imbibition index and the apparent liquid permeability measurements were then used to determine the impact of the NPs concentration (i.e. 0.0, 0.5, 1.0, 2.0 wt%) on the FLCE. In order to understand the filtration control mechanisms of the NPs enhanced fracturing fluids, we have analyzed the field emission scanning electron microscope (FESEM) images of the shale samples, which provided detailed description of how NPs are attached to the shale surface. The experimental results indicated that the CaCO3NPs have excellent FLCE. The imbibition index and the apparent liquid permeability decreased significantly along with the increasing NPs concentration. The optimum NPs concentration was found to be 1.0 wt%. Analyses of the FESEM images demonstrated that the distribution of the NPs on shale surface is selective. The NPs mainly attached on the rough areas of the shale surface. The process of the NPs adsorption-sealing leads to the reduction of the path of the fluid flow into the shale matrix, and in turn, controls the fracturing fluid filtration. Ultimately, four kinds of sealing patterns were observed including (i-) plugging, (ii-) bridging, (iii-) plugging and accumulation, (iv-) bridging and accumulation.In this study, the rheological behavior and density of MoS2/sesame oil based nano-lubricants are experimentally investigated. The transmission electron microscopy and x-ray diffraction technique were utilized to confirm the morphology of the MoS2nano particles. The experimental measurements are carried out at temperature varying from 313 to 393 K, shear rate ranging from 10to 70 s-1and solid volume fraction ranging from 0.2% to 1.2%. For the both nano-lubricants and pure lubricant, shear thinning behavior is observed. The influence of temperature and nanoparticle concentration on viscosity and density of nano lubricants are examined. The viscosity and density of nano-lubricants increased with an increase of solid volume fraction, while, it decreased with an increase in temperature. Moreover, the effect of nano particle concentration on the pumping power of lubricant flow are discussed. Finally, an experimental correlation was developed for predicting the viscosity of MoS2/sesame oil based nano-lubricant.To reduce overall patient radiation exposure in some clinical scenarios (since cancer patients need frequent follow-ups), noncontrast CT is not used in some institutions. However, although less desirable, noncontrast CT could provide additional important information. In this article, we propose a deep subtraction residual network based on adjacency content transfer to reconstruct noncontrast CT from contrast CT and maintain image quality comparable to that of a CT scan originally acquired without contrast. To address the slight structural dissimilarity of the paired CT images (noncontrast CT and contrast CT) due to involuntary physiological motion, we introduce a contrastive loss network derived from the adjacency content-transfer strategy. We evaluate the results of various similarity metrics (MSE, SSIM, NRMSE, PSNR, MAE) and the fitting curve (HU distribution) of the output mapping to estimate the reconstruction performance of the algorithm. To build the model, we randomly select a total of 15,405 CT paired images (noncontrast CT and contrast-enhanced CT) for training and 10,270 CT paired images for testing. The proposed algorithm preserves the robust structures from the contrast-enhanced CT scans and learns the noncontrast attenuation pattern from the noncontrast CT scans. During the evaluation, the deep subtraction residual network achieves higher MSE, MAE, NRMSE, and PSNR scores (by 30%) than those of the baseline models (BEGAN, CycleGAN, Pixel2Pixel) and better simulates the HU curve of noncontrast CT attenuation. After validation based on an analysis of the experimental results, we can report that the noncontrast CT images reconstructed by our proposed algorithm not only preserve the high-quality structures from the contrast-enhanced CT images, but also mimic the CT attenuation of the originally acquired noncontrast CT images.