Jespersenbock1956

Patients with coronavirus disease 2019 (COVID-19) who have underlying malignancy have a higher mortality rate compared with those without cancer, although the magnitude of such excess risk is not clearly defined. We performed a systematic review and pooled analysis to provide precise estimates of the mortality rate among patients with both cancer and COVID-19.

A systematic literature search involving peer-reviewed publications, preprintsand conference proceedings up to July 16, 2020, was performed. The primary end-point was the case fatality rate (CFR), defined as the rate of death among patients with cancer and COVID-19. The CFR was assessed with a random effects model, which was used to derive a pooled CFR and its 95% confidence interval (CI).

Fifty-two studies, involving a total of 18,650 patients with both COVID-19 and cancer, were selected for the pooled analysis. A total of 4243 deaths were recorded in this population. The probability of death was 25.6% (95% CI 22.0%-29.5%; I

=48.9%) in this patient population.

Patients with cancer who develop COVID-19 have high probability of mortality. Appropriate and aggressive preventive measures must be taken to reduce the risk of COVID-19 in patients with cancerand to optimally manage those who do contract the infection.

Patients with cancer who develop COVID-19 have high probability of mortality. Appropriate and aggressive preventive measures must be taken to reduce the risk of COVID-19 in patients with cancer and to optimally manage those who do contract the infection.Toxic metals cause substantial reduction in crop yields every year. Therefore, worldwide scientific efforts are being made to reduce such losses in crop productivity by using certain chemical protectants such as nutrients like sulfur (S), hydrogen sulfide (H2S), glutathione (GSH), etc. Therefore in this study, we have tested potential of additional S, along with probable involvement of H2S and GSH in mitigating hexavalent chromium (CrVI) toxicity in tomato, pea and brinjal seedlings. Chromium (VI) decreased shoot and root length, endogenous H2S, and cell viability due to greater Cr accumulation that led to cell death in roots. Chromium (VI) enhanced oxidative stress markers i.e. superoxide radical, hydrogen peroxide, lipid peroxidation and protein oxidation due to down-regulation in ascorbate-glutathione cycle. However, additional S reversed toxic effect of Cr(VI). Chromium (VI) slightly stimulated enzymes of glutathione biosynthesis. Besides this, the results also showed that addition of buthionine sulphoximine (BSO, synthetic inhibitor of glutathione biosynthesis) interestingly further enhanced Cr(VI) toxicity even in the presence of additional S. But this effect of BSO was reversed by the addition of GSH. Interestingly, hydroxylamine (HA, synthetic inhibitor of cysteine desulfhydrase) had also further increased Cr(VI) toxicity even in the presence of additional S but sodium hydrosulfide (NaHS, an H2S donor) reversed this effect. Furthermore, ameliorative behaviour of NaHS against Cr(VI) toxicity was reversed by the hypotaurine (HT, a H2S scavenger). All together results suggested that additional S involved GSH and H2S in mitigating Cr(VI) toxicity in studied vegetables, in which GSH acted downstream of H2S signal.How is semantic information in the mental lexicon accessed and selected during reading? Readers process information of both the foveal and parafoveal words. Recent eye-tracking studies hint at bi-phasic lexical activation dynamics, demonstrating that semantically related parafoveal previews can either facilitate, or interfere with lexical processing of target words in comparison to unrelated previews, with the size and direction of the effect depending on exposure time to parafoveal previews. However, evidence to date is only correlational, because exposure time was determined by participants' pre-target fixation durations. Here we experimentally controlled parafoveal preview exposure duration using a combination of the gaze-contingent fast-priming and boundary paradigms. We manipulated preview duration and examined the time course of parafoveal semantic activation during the oral reading of Chinese sentences in three experiments. Semantic previews led to faster lexical access of target words than unrelated previews only when the previews were presented briefly (80 ms in Experiments 1 and 3). Longer exposure time (100 ms or 150 ms) eliminated semantic preview effects, and full preview without duration limit resulted in preview cost, i.e., a reversal of preview benefit. Our results indicate that high-level semantic information can be obtained from parafoveal words and the size and direction of the parafoveal semantic effect depends on the level of lexical activation.The electron emission model of a negative electron affinity graded-bandgap AlGaAs/GaAs electron-injection cathode was developed from two-dimensional continuity equations. The emission current was obtained from a simulation of the model, and the emission current efficiency and emission current per unit length were calculated. Based on the simulation results and preparation conditions, the range of optimum parameters for the cathode structure were determined. The ranges of optimum thickness for the p-AlGaAs and the graded-bandgap p-AlGaAs layers were 0.05-0.15 μm and 0.1-0.3 μm, respectively. The optimum width of the base electrode ranged from 1 to 4 μm, and the optimum molar ratios of Al in the p-AlGaAs and the n-AlGaAs layers were 0.2-0.3 and 0.4-0.5, respectively. This abrupt PN heterojunction inhibited the hole current and increased the emission current efficiency, with a maximum value of 25.3%. According to the emission current per unit length, the optimum range of width of emission unit surface was 6 to 10 μm, and the peak emission current per unit length reached 43.2 μA/μm.Groundwater protection against agricultural diffuse nitrate pollution is of paramount importance for safeguarding groundwater-dependent aquatic ecosystems and protecting human health by securing clean groundwater for drinking water production. Nitrate vulnerability assessment of aquifers is the core of a scientifically sound strategy for management and protection of groundwater by authorities. A multitude of methods exists for assessing intrinsic aquifer vulnerability. The objective of this paper is to develop a nitrate-specific groundwater vulnerability assessment method based on the globally recognized DRASTIC method, which was developed by the US Environmental Protection Agency in the 1980s. Piperaquine in vivo We propose a new method "DRASTIC-N″ for assessing aquifer nitrate vulnerability, which for the first time expands the seven original geological and hydrogeological parameters with a geochemical parameter for redox condition. The development of DRASTIC-N is based on the longstanding Danish practice of performing detailed groundwater mapping based on dense sampling of geophysical, geological, and geochemical data.