Ibsentierney6260

p) injections. Following the saffron or crocin administration, histological evaluation and quantitative analysis represented less inflammatory cell infiltration and less collagen composition, compared to control group. Moreover, the oxidative stress was significantly reduced in treatment groups.

These findings suggest that a hydro-alcoholic extract of saffron or its active compound, crocin, is a potentially novel therapeutic strategy for the prevention of adhesions formation and might be used as beneficial anti-inflammatory or anti-fibrosis agents in clinical trials.

Abdominal surgeries/post-surgical adhesions.

Abdominal surgeries/post-surgical adhesions.

Traumatic brain injury (TBI) results in death or long term functional disabilities. Eugenol is demonstrated to be beneficial in a range of experimental models of neurological disorders via its anti-inflammatory and antioxidant properties. Thus, the present study was designed to investigate the neuroprotective effects of eugenol in a weight-drop induced rat model of TBI.

Rats were assigned into five groups; control and TBI groups pretreated with vehicle, and three TBI groups pretreated with different doses of eugenol (25, 50, and 100mg/kg/day,

, seven consecutive days). read more Except for the control, all other groups were subjected to TBI using Marmarou's weight-drop method. 24 h after TBI, locomotor functions and short term memory were evaluated. Lastly animals were scarified and the estimation of lipid peroxidation in brain tissue, blood-brain barrier (BBB) integrity, brain water content (brain edema) and histopathology of the brain tissue were performed.

Weight-drop induced TBI caused functional disabilities in the rats as indicated by impairment in locomotor activities and short term memory. The TBI also resulted in augmented neuronal cell death designated by chromatolysis. The results also showed disruption in the BBB integrity, increased edema, and lipid peroxidation in the brain of the rats exposed to trauma. Pretreatment with eugenol (100mg/kg) ameliorated histopathological, neurochemical, and behavioral consequences of trauma.

For the first time this study revealed that eugenol can be considered as a potential candidate for managing the functional disabilities associated with TBI because of its antioxidant activities.

For the first time this study revealed that eugenol can be considered as a potential candidate for managing the functional disabilities associated with TBI because of its antioxidant activities.

stem bark is used as a remedy for malaria in north-central and southern Nigeria. Based on its traditional use, this study was conducted to investigate the antiplasmodial, antinociceptive and antipyretic potential of an extract of

stem bark.

A 70% v/v ethanol extract of stem bark of

was prepared by cold maceration. Fractions (dichloromethane, ethyl acetate, and residual) were also prepared. The extract was screened for hemolytic, cytotoxic and antiplasmodial activity effects. The effect of the extract and fractions against chloroquine-sensitive (3D7) and multi-drug resistant (W2mef)

was assessed. Acute toxicity test, acetic acid-induced abdominal writhing in mice, and lipopolysaccharide-induced fever in rats were also employed to screen the extract. Chromatographic fingerprints of the extract and active fraction were obtained.

extract showed no cytotoxic or significant hemolytic effects and did not cause acute toxicity or mortality. The ethanol extract exhibited moderate antiplasmodial activity while the dichloromethane fraction showed high activity against

3D7 (IC

=6.44μg/ml) and W2mef (IC

=6.30μg/ml) respectively. The extract elicited significant (

<0.05) attenuation of acetic acid-induced writhing and significantly (

<0.05) ameliorated lipopolysaccharide-induced pyrexia at 300mg/kg. The HPLC profile of the dichloromethane fraction showed peaks with retention times that corresponded with those of rutin and caffeic acid.

extract has antiplasmodial, antinociceptive and antipyretic potential and its antiplasmodial constituents are concentrated in its dichloromethane fraction.

Burkea africana extract has antiplasmodial, antinociceptive and antipyretic potential and its antiplasmodial constituents are concentrated in its dichloromethane fraction.Background and Aim; Chronic urticaria (CU) is a fluctuating and pruritic erythematous papule that persists for over six weeks. It affects 0.5-1% of the population and interferes with subjective well-being and daily life. Its etiology is highly complex which makes a causal and/or curative treatment difficult. Nonsedating H1-antihistamines are given as symptomatic therapy, which reduces symptoms effectively in less then 50% of patients. In Unani medicine, urticaria is known as Shara and treated according to its established etiology. The present study objective was to investigate the effect of herbal combination of Unani medicine (HCUM) comprising Rosa damascena Mill, Bambusa arundinacea Linn, Cinnamomum camphora Linn, Mentha arvensis Linn, in comparison with Levocetirizine in CU. Experimental procedure; This randomized open-labeled standard control clinical trial was conducted between 42 male/female patients aged 20-50 years with moderate to severe CU who were randomly allocated in a 31 ratio into HCUM and Levocetirizine 5 mg groups. HCUM powder 5.125 Gm and Levocetirizine 5 mg were given for 4 weeks. Urticaria activity score (UAS7) and chronic urticaria quality of life questionnaire (CU-Q2oL) were primary and secondary outcomes and analyzed per protocol. Results A total of 40 patients completed the study. Data analysis showed a significant decrease (P= less then 0.001) in the scores of UAS7 (32.43 ± 2.34-14.03 ± 2.16 and 32.10 ± 2.33-28.40 ± 3.78) and CU-Q2oL (67.57 ± 9.56-36.50 ± 3.01 and 65.20 ± 11.78-59.60 ± 11.13) in HCUM and Levocetirizine groups respectively. Conclusion As an alternative treatment in terms of safety, efficacy, tolerability, and quality of life the HCUM treatment proved to be more effective than Levocetirizine 5 mg in moderate to severe CU.The Inonotus obliquus (I. obliquus) mushroom was traditionally used to treat various gastrointestinal diseases. For many years, mounting evidence has indicated the potential of I. obliquus extracts for treatment of viral and parasitic infections. Furthermore, substances from I. obiquus have been shown to stimulate the immune system. The most promising finding was the demonstration that I. obliquus has hypoglycemic and insulin sensitivity potential. This review summarizes the therapeutic potential of I. obliquus extracts in counteracting the progression of cancers and diabetes mellitus as well as their antiviral and antiparasitic activities and antioxidant role. As shown by literature data, various authors have tried to determine the molecular mechanism of action of I. obliquus extracts. Two mechanisms of action of I. obliquus extracts are currently emerging. The first is associated with the broad-sense impact on antioxidant enzymes and the level of reactive oxygen species (ROS). The other is related to peroxisome proliferator-activated receptor gamma (PPARγ) effects. This receptor may be a key factor in the anti-inflammatory, antioxidant, and anti-cancer activity of I. obliquus extracts. It can be concluded that I. obliquus fits the definition of functional food and has a potentially positive effect on health beyond basic nutrition; however, studies that meet the evidence-based medicine (EBM) criteria are needed.A 30-year-old woman (gravida 3, para 1 + 1), with a previous uncomplicated pregnancy and vaginal delivery, was diagnosed with both type 1 Arnold-Chiari malformation and symptomatic multi-level lumbar disc prolapse in her inter-pregnancy period. During this index pregnancy, she experienced progressively worsening occipital headaches radiating to both arms, severe low back pain radiating to both legs and weakness in both legs. She had no urinary or bowel symptoms. She was successfully managed through pregnancy by a multidisciplinary team that included obstetricians, orthopedic and neurosurgeons, obstetric anesthetists and physiotherapists. She had an uncomplicated cesarean delivery under spinal anesthesia. As far as we can tell, this is the first report of both conditions in a pregnant woman.A complete hydatidiform mole coexisting with a fetus (CHMCF) is a rare form of twin pregnancy. High-risk gestational trophoblastic neoplasia (GTN) can occur after a CHMCF pregnancy, although the frequency is low. In cases of GTN, the clinical diagnosis and that based on the International Federation of Gynecology and Obstetrics (FIGO) scoring system can differ. This case report concerns a patient with a choriocarcinoma that was initially diagnosed and treated as a low-risk stage III GTN following a live birth from a CHMCF pregnancy. We used short tandem repeat (STR) analysis to identify the causative pregnancy as the patient's earlier complete hydatidiform mole. Clinicians should anticipate a high-risk GTN when treating persistent trophoblastic disease (PTD) in patients with a non-typical course.

Diabetes mellitus is a leading cause of nephropathy and end-stage renal disease. However, diabetic nephropathy during pregnancy in patients with normal glomerular filtration rate and subsequent progression to end-stage renal disease has not been well studied.

This report presents two patients with poorly controlled type 1 diabetes mellitus who had diabetic nephropathy with preserved estimated glomerular filtration rate (Case 1 117mL/min/1.73m

 ; Case 2 79mL/min/1.73m

) and shared a similar clinical course, with glomerular filtration rates decreasing by approximately one-half during pregnancy and progression to end-stage renal disease within the first year postpartum. Both women had a long history of type 1 diabetes 18years and 24years for case 1 and case 2 respectively. The first patient's course of pregnancy was complicated by difficult-to-control blood glucose and hypertension with subsequent preeclampsia. The second patient's course of pregnancy was complicated by difficult-to-control blood sugars and preterm labor resulting in classical cesarean delivery at 24weeks. Both patients had renal biopsies shortly after delivery as their renal function continued to worsen postpartum. Both kidney biopsies demonstrated advanced diabetic nephropathy changes and ultimately required chronic renal replacement therapy within 7-9months postpartum.

Comprehensive family planning discussions with women who have diabetic nephropathy should include the risks of renal disease progression, even in those patients with preserved renal function at the time of conception.

Comprehensive family planning discussions with women who have diabetic nephropathy should include the risks of renal disease progression, even in those patients with preserved renal function at the time of conception.Over the centuries, the development of knowledge about poisons and antidotes depended on their conceptualization, however, a range of poisons and the concept of antidote evolved. With the passing of time, different substances of plant, animal, and mineral origin, moreover, man-made ones, were used deliberatively, accidentally, or unintentionally as poisons. The concept of antidote was changing in line with the progress of medicine and understanding of the mechanism of how poison works. From this perspective, the history of antidotes may be considered as the quintessence of changes within toxicology. Among the theories of antidote, the most interesting is the concept of a universal one, because it has never become obsolete. This review article focuses on the changing conceptualization of antidotes. It contains an analysis of historical toxicological treatises on antidotes and PubMed articles on the same topic.