Hvassmaldonado2532

Wide experimental evidence has been provided in the last decade concerning the neuroprotective effects of phytochemicals in a variety of neurodegenerative disorders. Generally, the neuroprotective effects of bioactive compounds belonging to different phytochemical classes are attributed to antioxidant, anti-aggregation, and anti-inflammatory activity along with the restoration of mitochondrial homeostasis and targeting alterations of cell-clearing systems. Far from being independent, these multi-target effects represent interconnected events that are commonly implicated in the pathogenesis of most neurodegenerative diseases, independently of etiology, nosography, and the specific misfolded proteins being involved. Nonetheless, the increasing amount of data applying to a variety of neurodegenerative disorders joined with the multiple effects exerted by the wide variety of plant-derived neuroprotective agents may rather confound the reader. The present review is an attempt to provide a general guideline about the most relevant mechanisms through which naturally occurring agents may counteract neurodegeneration. With such an aim, we focus on some popular phytochemical classes and bioactive compounds as representative examples to design a sort of main highway aimed at deciphering the most relevant protective mechanisms which make phytochemicals potentially useful in counteracting neurodegeneration. In this frame, we emphasize the potential role of the cell-clearing machinery as a kernel in the antioxidant, anti-aggregation, anti-inflammatory, and mitochondrial protecting effects of phytochemicals.Lens distortion is closely related to the spatial position of depth of field (DoF), especially in close-range photography. The accurate characterization and precise calibration of DoF-dependent distortion are very important to improve the accuracy of close-range vision measurements. In this paper, to meet the need of short-distance and small-focal-length photography, a DoF-dependent and equal-partition based lens distortion modeling and calibration method is proposed. Firstly, considering the direction along the optical axis, a DoF-dependent yet focusing-state-independent distortion model is proposed. By this method, manual adjustment of the focus and zoom rings is avoided, thus eliminating human errors. Secondly, considering the direction perpendicular to the optical axis, to solve the problem of insufficient distortion representations caused by using only one set of coefficients, a 2D-to-3D equal-increment partitioning method for lens distortion is proposed. Accurate characterization of DoF-dependent distortion is thus realized by fusing the distortion partitioning method and the DoF distortion model. Lastly, a calibration control field is designed. After extracting line segments within a partition, the de-coupling calibration of distortion parameters and other camera model parameters is realized. Experiment results shows that the maximum/average projection and angular reconstruction errors of equal-increment partition based DoF distortion model are 0.11 pixels/0.05 pixels and 0.013°/0.011°, respectively. This demonstrates the validity of the lens distortion model and calibration method proposed in this paper.Inflammatory bowel diseases (IBDs) are chronic conditions that can benefit from the combined treatment of adenosine receptor agonists and hyaluronic acid (HA), which, binding the CD44, has pro-survival effects. Therefore, this study investigated the effects of a mixture of polynucleotides and HA in an experimental model of dinitrobenzenesulfonic acid (DNBS)-induced colitis. A group of 40 rats received a single intra-colonic instillation of DNBS, and after 6 h, animals were randomized to receive daily (i) saline solution; (ii) polynucleotides (Poly; 8 mg/kg); (iii) polynucleotides (8 mg/kg) plus hyaluronic acid (HA; 15 mg/kg); and (iv) hyaluronic acid (HA; 15 mg/kg). UGT8IN1 Rats in the control group (n = 10) received saline solution only. Seven days after induction, animals receiving Poly plus HA showed reduced clinical signs, weight loss and colon shortening, ameliorated macroscopic and histological damage, and apoptosis. Moreover, the combined treatment reduced the positivity in the colonic infiltrate of CD3 positive T cells, CD20 positive B cells and CD44. Furthermore, Poly plus HA reduced colonic myeloperoxidase activity and malondialdehyde, indicating a dampening of the inflammatory infiltrate and oxidation products. Our research demonstrated that a combined treatment of polynucleotides with hyaluronic acid had a protective effect in a model of ulcerative colitis, suggesting that this association deserves further attention for the treatment of IBDs.Hydrogen embrittlement (HE) is one of the main limitations in the use of advanced high-strength steels in the automotive industry. To have a better understanding of the interaction between hydrogen (H) and a complex phase steel, an in-situ method with plasma charging was applied in order to provide continuous H supply during mechanical testing in order to avoid H outgassing. For such fast-H diffusion materials, only direct observation during in-situ charging allows for addressing H effects on materials. Different plasma charging conditions were analysed, yet there was not a pronounced effect on the mechanical properties. The H concentration was calculated while using a simple analytical model as well as a simulation approach, resulting in consistent low H values, below the critical concentration to produce embrittlement. However, the dimple size decreased in the presence of H and, with increasing charging time, the crack propagation rate increased. The rate dependence of flow properties of the material was also investigated, proving that the material has no strain rate sensitivity, which confirmed that the crack propagation rate increased due to H effects. Even though the H concentration was low in the experiments that are presented here, different technological alternatives can be implemented in order to increase the maximum solute concentration.A vulnerability curve is an important tool for the rapid assessment of drought losses, and it can provide a scientific basis for drought risk prevention and post-disaster relief. Those populations with difficulty in accessing drinking water because of drought (hereon "drought at risk populations", abbreviated as DRP) were selected as the target of the analysis, which examined factors contributing to their risk status. Here, after the standardization of disaster data from the middle and lower reaches of the Yangtze River in 2013, the parameter estimation method was used to determine the probability distribution of drought perturbations data. The results showed that, at the significant level of α = 0.05, the DRP followed the Weibull distribution, whose parameters were optimal. According to the statistical characteristics of the probability density function and cumulative distribution function, the bulk of the standardized DRP is concentrated in the range of 0 to 0.2, with a cumulative probability of about 75%, of which 17% is the cumulative probability from 0.