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Purpose Triple negative breast cancer (TNBC) accounts for approximately 15% of breast cancer cases and is associated with a poor prognosis. In this retrospective study of patients undergoing radiation therapy as part of their treatment, disease-free survival (DFS) and overall survival (OS) of TNBC patients were examined in relation to clinical and treatment-related factors. Patients and Methods The electronic records of 214 consecutive TNBC patients treated with surgery followed by radiotherapy at the Mid North Coast Cancer Institute between 2006 and 2016 were reviewed. Overall survival and DFS times were analyzed using the Kaplan-Meier method; multivariate Cox proportional hazard regression modelling was used to assess the significance of prognostic factors. Results The majority of tumors were T1 (51.9%), followed by T2 (39.2%) and T3 (6.1%). For the whole group, mean DFS was 106.4 (SD 48.7) months; OS 109.4 (SD 52.1) months. Radiotherapy technique, fractionation protocol and laterality were not significant factors for DFS or OS (p>0.05). However, compared to breast conservation, mastectomy was associated with poorer DFS (mean 114.2 vs 65.2 months; p 5cm and positive nodal status is associated with poorer DFS in TNBC patients. Radiotherapy technique or fractionation protocol were not associated with differences in DFS or OS in our patient cohort. © 2020 Wen et al.Purpose Opioid analgesics remain the cornerstone of treatment for severe trauma pain in the emergency setting, but there are barriers to their use. This post hoc analysis of a previously reported trial (MEDITA) investigated the efficacy and safety of low-dose methoxyflurane versus intravenous (IV) morphine for severe trauma pain. Patients and Methods MEDITA was a Phase IIIb, randomized, active-controlled, parallel-group, open-label study in Italian pre-hospital units and emergency departments (EudraCT 2017-001565-25; NCT03585374). Adult patients (N=272) with moderate-to-severe trauma pain (score ≥4 on the Numerical Rating Scale [NRS]) were randomized 11 to inhaled methoxyflurane (3 mL) or standard analgesic treatment (SAT; IV paracetamol 1g or ketoprofen 100mg for moderate pain [NRS 4-6] and IV morphine 0.1mg/kg for severe pain [NRS ≥7]). Analyses were performed for the severe pain subgroup. The primary efficacy variable was the overall change from baseline in visual analog scale (VAS) pain intensity at 3, 5 uperior short-term pain relief to IV morphine in patients with severe trauma pain and offers an effective non-narcotic treatment option. © 2020 Voza et al.Background Chronic pain in later life is a worldwide problem. In younger patients, chronic pain affects life satisfaction negatively; however, it is unknown whether this outcome will extend into old age. Objective This study examines which factors determine life satisfaction in older adults who suffer from chronic pain with respect to socio-demographics, lifestyle behaviors, pain, and comorbidities. Methods This cross-sectional study recruited a random sample of people ≥65 years old living in south-eastern Sweden (N= 6611). A postal survey addressed pain aspects and health experiences. Three domains from the Life Satisfaction Questionnaire (LiSat-11) were used to capture the individual's estimations of overall satisfaction (LiSat-life), somatic health (LiSat-somhealth), and psychological health (LiSat-psychhealth). Results Respondents with chronic pain (2790, 76.2±7.4 years old) rated lower on life satisfaction than those without chronic pain, with medium effect size (ES) on LiSat-somhealth (r = 0.38, P lessies and severe pain to improve patients' life satisfaction. © 2020 Dong et al.Purpose Complex regional pain syndrome (CRPS) is a rare neuropathic pain condition characterized by sensory, motor and autonomic alterations. SKI-606 solubility dmso Previous investigations have shown that transcranial direct current stimulation (tDCS) and transcutaneous electrical nerve stimulation (TENS) can alleviate pain in various populations, and that a combination of these treatments could provide greater hypoalgesic effects. In the present case report, we describe the effect of tDCS and TENS treatment on pain intensity and unpleasantness in a patient suffering from chronic CRPS. Results The patient was a 37-year-old woman, suffering from left lower limb CRPS (type I) for more than 5 years. Despite medication (pregabalin, tapentadol, duloxetine), rehabilitation treatments (sensorimotor retraining, graded motor imagery) and spinal cord stimulation (SCS), the participant reported moderate to severe pain. Treatments of tDCS alone (performed with SCS turned off during tDCS application, 1 session/day, for 5 consecutive days) did not significantly decrease pain. Combining tDCS with TENS (SCS temporarily turned off during tDCS, 1 session/day, for 5 consecutive days) slightly reduced pain intensity and unpleasantness. Discussion Our results suggest that combining tDCS and TENS could be a therapeutic strategy worth investigating further to relieve pain in chronic CRPS patients. Future studies should examine the efficacy of combined tDCS and TENS treatments in CRPS patients, and other chronic pain conditions, with special attention to the cumulative and long-term effects and its effect on function and quality of life. © 2020 Houde et al.Background Eating habits are a major concern with regard to the health status of university students. This study aimed to identify patterns of eating habits among undergraduate medical students and to investigate their relationship to sociodemographic, socioeconomic, and psychological factors. Methods This cross-sectional study included 378 undergraduate medical students aged 19-26 from the Faculty of Medicine at King Abdulaziz University, Jeddah, Saudi Arabia. Students were in their second through sixth academic year. Data were gathered with a self-administered questionnaire encompassing questions on sociodemographics, eating habits, and psychological factors. Results Eating habits score was much lower among students who were smokers, lived in rented places, lived alone, had separated parents, and did not exercise regularly. In multivariate analysis, multiple psychological factors, such as living alone and stressed, were found to be associated with eating patterns. Conclusion A majority of undergraduate medical students had unhealthy eating patterns, and socioeconomic and psychological elements were significantly affecting eating patterns. © 2020 Alzahrani et al.Background Increasing the availability of safe blood is a major challenge in developing countries. Given the scant amount of community-based data in Africa, this study examines the knowledge, attitudes, and practices of blood donation of Ethiopian adults. Methods A cross-sectional study was conducted on 421 adult residents of Adama town using face-to-face interviews with translated questionnaires. Knowledge and attitude levels were assessed using a set of questions and those who answered above mean for knowledge and attitude questions were categorized as above-average knowledge level and favorable attitude, respectively. link2 The data were coded and entered into EPI Info™ version 7, transferred to SPSS version 25 for cleaning and analysis. All variables with p less then 0.25 in the bivariable analysis were examined as candidate variables in the multivariable logistic regression models. Results Less than half, 47% (95% CI 42-52%) of the study participants have above-average knowledge level about blood donation and 48% (95% CI 43-53%) have favorable attitudes towards blood donation. Only 17% (95% CI 13-21%) of study participants ever donated blood of which 14.6% of them donated for replacement and less than 2% (1.95%) are voluntary donors. Younger age of 18-25 AOR 95% CI 3.40 (1.30, 12.43), having good knowledge AOR 95% CI 2.21 (1.26, 3.89) and favorable attitude AOR 95% CI 10.25 (4.90, 21.44) were factors independently associated with blood donation practice. Conclusion The level of blood donation practiced in the study area is low. Low knowledge and poor attitudes are independent predictors of low inclination to donate, so awareness creation and improving attitudes in blood donation campaigns, particularly among older people is necessary to increase voluntary blood donation. © 2020 Beyene.Rosuvastatin, is a widely-used statin for the treatment of hypercholesterolemia and the prevention of cardiovascular diseases. Although rosuvastatin is well tolerated, about 3/10.000 patients can suffer severe myopathy. Rhabdomyolysis is a severe medical condition that causes injury to the skeletal muscle, electrolyte imbalances, acute renal failure and extreme creatine kinase (CK) elevation. Little is known regarding the molecular involvement of rosuvastatin-induced rhabdomyolysis (RIR). It has been demonstrated that genomic variants associated with decreased enzymatic activity of proteins are important determinants in plasmatic and skeletal muscle distribution of rosuvastatin and its toxicity. Until now, no interactions of ticagrelor, ezetimibe and rosuvastatin have been described with the consideration of pharmacogenomics predisposition. The present report involves a whole-exome sequencing (WES), in a patient affected by rosuvastatin-induced rhabdomyolysis. A pharmacogenomic dissection was performed by anacs analysis presented here represents an innovative way to identify genomic variants contributing with RIR´s origin and evokes the polygenic nature of adverse drug reactions. © 2020 Calderon-Ospina et al.Background and Objectives Rheumatoid arthritis (RA) is an inflammatory disease treated with nonsteroidal anti-inflammatory drugs that have different side effects. One of the plants used for this purpose in the traditional medicine is Trachyspermum ammi. The present study aimed at investigating the anti-inflammatory effect of this plant on type II collagen-induced arthritis (CIA) in Wistar rats. Materials and Methods The study was performed on 35 male Wistar rats. Seven rats were considered as the healthy control group (normal group), and CIA was stablished in the rest. The rats with a model of inflammatory arthritis were divided into four groups. One group did not receive any treatment and three groups were treated orally with ibuprofen (15 mg/kg), aqueous extract of the T. ammi seeds (100 mg/kg), or their combination for 30 days. The effect of different treatments was investigated on the paw thickness, arthritis score, and mRNA level of COX2 and iNOS genes. Results CIA increased paw thickness, arthritis score, and COX2 and iNOS mRNA levels compared to those of the normal group. Treatment with ibuprofen and aqueous extract alone or in combination reduced the studied variables. Reduction in the paw thickness, arthritis score, and iNOS mRNA level was more in the ibuprofen-treated group than the T. ammi extract-treated group, but treatment with T. ammi extract reduced COX2 mRNA level more than ibuprofen. Conclusion It seems that the aqueous extract of T. ammi can be used alone or in combination with ibuprofen to treat RA. © 2020 Korani and Jamshidi.Objective To investigate which plasma lipid parameters are useful for detecting chronic kidney disease (CKD) in a Chinese population without known CKD or renal impairment. link3 Methods This was a prospective study. In southern Chinese cities from 2012 to 2013, a total of 1037 subjects aged ≥ 18 years old received a survey. Logistic regression and multiple linear regression analyses were performed. The lipid parameters studied included total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol (nHDL-C), TG/HDL-C ratio, TC/HDL-C ratio and nHDL-C/HDL-C ratio. Results After adjusting for confounding factors, the fourth percentile of logTG/HDL-C was observed to be an independent risk factor for CKD (OR = 2.453, P less then 0.001), and the highest quantile of the logTG/HDL-C ratio was associated with a higher prevalence of CKD (P less then 0.05). This risk was reduced when the model was adjusted with Insulin resistance (IR) (OR = 2.034, P less then 0.